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Progresivní multifokální leukoencefalopatie – Epidemiologie, imunitní odpověď, klinické rozdíly, léčba

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dc.title Progresivní multifokální leukoencefalopatie – Epidemiologie, imunitní odpověď, klinické rozdíly, léčba cs
dc.title Progressive multifocal leukoencephalopathy - Epidemiology, immune response, clinical differences, treatment en
dc.contributor.author Snopková, Svatava
dc.contributor.author Štourač, Petr
dc.contributor.author Fašaneková, Lenka
dc.contributor.author Mihalčin, Matúš
dc.contributor.author Havlíčková, Kateřina
dc.contributor.author Svačinka, Radek
dc.contributor.author Volfová, Pavlína
dc.contributor.author Snopek, Petr
dc.contributor.author Husa, Petr
dc.relation.ispartof Epidemiologie, Mikrobiologie, Imunologie
dc.identifier.issn 1210-7913 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 2019
utb.relation.issue 1
dc.citation.spage 24
dc.citation.epage 31
dc.type article
dc.language.iso en
dc.publisher Czech Medical Association J.E. Purkyne
dc.relation.uri https://www.prolekare.cz/en/journals/epidemiology-microbiology-immunology/2019-1-20/progressive-multifocal-leukoencephalopathy-epidemiology-immune-response-clinical-differences-treatment-112627
dc.subject CD4/CD8 ratio en
dc.subject cellular immunity en
dc.subject HIV en
dc.subject multiple sclerosis en
dc.subject progressive multifocal leukoencephalopathy en
dc.description.abstract Progressive multifocal leukoencephalopathy (PML) is a severe disease of the central nervous system with very high mortality. It is caused by the JC virus with high seroprevalence, at up to 80%. Development of PML is typically opportunistic, particularly in acquired immunodeficiency syndrome, and usually affects patients with profound immunodeficiency. Furthermore, as a result of highly efficient immunosuppressive and immunomodulatory treatments in recent years, the number of PML cases has increased in the general population. In this article, the authors mention virological and epidemiological relationships and characteristic manifestations of PML. Possible relationships of humoral and cellular immunity are discussed and limited treatment options including prophylaxis are mentioned. © 2019, Czech Medical Association J.E. Purkyne. All rights reserved. en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1009046
utb.identifier.obdid 43880572
utb.identifier.scopus 2-s2.0-85068462634
utb.identifier.wok 000471143400004
utb.identifier.pubmed 31181949
utb.identifier.coden EMIME
utb.source j-scopus
dc.date.accessioned 2019-09-19T07:56:13Z
dc.date.available 2019-09-19T07:56:13Z
utb.contributor.internalauthor Snopek, Petr
utb.fulltext.affiliation Snopková S. 1, Štourač P. 2, Fašaneková L. 1, Mihalčin M. 1, Havlíčková K. 1, Svačinka R. 1, Volfová P., Snopek P., Husa P. 1 1 Klinika infekčních chorob FN Brno a LF MU, Brno 2 Kliniky dětské anesteziologie a resuscitace FN Brno a LF MU doc.
utb.fulltext.dates Do redakce došlo dne 19. 3. 2018.
utb.scopus.affiliation Klinika infekčních chorob FN Brno a LF MU, Brno, Czech Republic; Neurologická klinika FN Brno a LF MU, Brno, Czech Republic; Interní hematoonkologická klinika FN Brno a LF MU, Brno, Czech Republic; Fakulta humanitních studií UTB, Zlín, Czech Republic
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