TBU Publications
Repository of TBU Publications

Black crowberry (empetrum nigrum L.) flavonoids and their health promoting activity

DSpace Repository

Show simple item record

dc.title Black crowberry (empetrum nigrum L.) flavonoids and their health promoting activity en
dc.contributor.author Juríková, Tünde
dc.contributor.author Mlček, Jiří
dc.contributor.author Škrovánková, Soňa
dc.contributor.author Balla, Štefan
dc.contributor.author Sochor, Jiří
dc.contributor.author Baroň, Mojmír
dc.contributor.author Sumczynski, Daniela
dc.relation.ispartof Molecules
dc.identifier.issn 1420-3049 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 21
utb.relation.issue 12
dc.type review
dc.language.iso en
dc.publisher MDPI AG
dc.identifier.doi 10.3390/molecules21121685
dc.relation.uri http://www.mdpi.com/1420-3049/21/12/1685
dc.subject Anthocyanins en
dc.subject Antioxidant activity en
dc.subject Flavonoids en
dc.subject Phenolic acids en
dc.subject Polyphenols en
dc.description.abstract Nowadays, much research attention is focused on underutilized berry crops due to the high antioxidant activity of fruits. Black crowberry (Empetrum nigrum L.) represents an important source of flavonols (quercetin, rutin, myricetin, naringenin, naringin, morin, and kaempferol) and anthocyanins. The fruit components could be utilised as natural colourants or as a part of functional foods and, because of the high antioxidant activity, the berries of black crowberry can be used in the treatment of diseases accompanied with inflammation, or as an effective antibacterial and antifungal remedy. Moreover, the reduction of lipid accumulation and total cholesterol as well as an improvement of postprandial hyperglycaemia have been proven. This review summarizes for the first time the main antioxidants (flavonoids) of black crowberry fruits, with a focus on their health promoting activity. © 2016 by the authors; licensee MDPI. en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1006935
utb.identifier.obdid 43875858
utb.identifier.scopus 2-s2.0-85007232624
utb.identifier.wok 000392140100079
utb.identifier.coden MOLEF
utb.source j-scopus
dc.date.accessioned 2017-06-27T08:13:17Z
dc.date.available 2017-06-27T08:13:17Z
dc.description.sponsorship TBU in Zlin [IGA/FT/2016/008, IGA 11/2016/591 ZF MENDELU, KEGA 038SPU-4/2014]
dc.rights Attribution 4.0 International
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.contributor.internalauthor Mlček, Jiří
utb.contributor.internalauthor Škrovánková, Soňa
utb.contributor.internalauthor Sumczynski, Daniela
utb.fulltext.affiliation Tunde Jurikova 1, *, Jiri Mlcek 2 , Sona Skrovankova 2 , Stefan Balla 1 , Jiri Sochor 3 , Mojmir Baron 3 and Daniela Sumczynski 2 1 Institute for Teacher Training, Faculty of Central European Studies, Constantine the Philosopher University in Nitra, Drazovska 4, SK-949 74 Nitra, Slovakia; sballa@ukf.sk 3 Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlin, nam. T. G. Masaryka 5555, CZ-760 01 Zlin, Czech Republic; mlcek@ft.utb.cz (J.M.); skrovankova@ft.utb.cz (S.S.); sumczynski@ft.utb.cz (D.S.) 4 Department of Viticulture and Enology, Faculty of Horticulture, Mendel University in Brno, Valticka 337, CZ-691 44 Lednice, Czech Republic; sochor.jirik@seznam.cz (J.S.); MojmirBaron@seznam.cz (M.B.) * Correspondence: tjurikova@ukf.sk; Tel.: +421-904-875-110
utb.fulltext.dates Received: 30 September 2016; Accepted: 28 November 2016; Published: 7 December 2016
utb.fulltext.references 1. Jurikova, T.; Rop, O.; Mlcek, J.; Sochor, J.; Balla, S.; Szekeres, L.; Hegedusova, A.; Hubalek, J.; Adam, V.; Kizek, R. Phenolic profile of edible honeysuckle berries (genus Lonicera) and their biological effects. Molecules 2012, 17, 61–79. [CrossRef] [PubMed] 2. Jurikova, T.; Sochor, J.; Rop, O.; Mlček, J.; Balla, S.; Szekes, L.; Zitný, R.; Zitka, O.; Kizek, R. Evaluation of polyphenolic profile and nutritional value of non-traditional fruit species in the Czech republic—A comparative study. Molecules 2012, 17, 8968–8981. [CrossRef] [PubMed] 3. Jurikova, T.; Balla, S.; Sochor, J.; Pohanka, M.; Mlcek, J.; Baron, M. Flavonoid profile of saskatoon berries (Amelanchier alnifolia Nutt.) and their health promoting effects. Molecules 2013, 18, 12571–12586. [CrossRef] [PubMed] 4. Skrovankova, S.; Sumczynski, D.; Mlcek, J.; Jurikova, T.; Sochor, J. Bioactive compounds and antioxidant activity in different types of berries. Int. J. Mol. Sci. 2015, 16, 24673–24706. [CrossRef] [PubMed] 5. Fruit and Vegetable Phytochemicals—Chemistry, Nutritional Value and Stability; de la Rosa, L.A.; Alvarez-Parrilla, E.; Gonzalez-Aguilar, G.A. (Eds.) Willey-Blackwell: Ames, IA, USA, 2010; p. 357. 6. Halvorsten, B.L.; Holte, K.; Myhrstad, M.C.; Barikno, I.; Hvattum, E.; Remberg, S.F.; Wold, A.B.; Haffner, K.; Baugerod, H.; Andersen, L.F.; et al. A systematic screening of total antioxidants in dietary plants. J. Nutr. 2002, 132, 461–471. 7. Seeram, N.P. Berry fruits: Compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. J. Agric. Food Chem. 2008, 56, 627–629. [CrossRef] [PubMed] 8. Fin, C. Empetrum nigrum crowberry. In The Encyclopedia of Fruits & Nuts; Janick, J., Paull, R.E., Eds.; CAB International: Wallingford, Oxfordshire, UK, 2008; p. 348. 9. Latti, A.A.; Riihinen, K.R.; Kainulanien, P.S. Analysis of anthocyanin variation in wild populations of bilberry (Vaccinium myrtillus L.) in Finland. J. Agric. Food Chem. 2008, 56, 190–196. [CrossRef] [PubMed] 10. Häkkinen, S.H.; Kärenlampi, S.O.; Mykkänen, H.M.; Törrönen, A.R. Influence of domestic processing and storage on flavonol contents in berries. J. Agric. Food Chem. 2000, 48, 2960–2965. [CrossRef] [PubMed] 11. Laaksonen, O.; Sandell, M.; Järvinen, R.; Kallio, H. Orosensory contributing compounds in crowberry (Empetrum nigrum) press-by products. Food Chem. 2011, 124, 1514–1524. [CrossRef] 12. Park, S.Y.; Lee, E.S.; Han, S.H.; Lee, H.Y.; Lee, S. Antioxidative effects of two native berry species, Empetrum nigrum var. japonicum k. Koch and Rubus buergeri miq., from the Jeju island of Korea. J. Food Biochem. 2012, 36, 675–682. [CrossRef] 13. Määttä-Riihinen, K.R.; Kamal-Eldin, A.; Mattila, P.H.; González-Paramás, A.M.; Törrönen, A.R. Distribution and contents of phenolic compounds in eighteen scandinavian berry species. J. Agric. Food Chem. 2004, 52, 4477–4486. [CrossRef] [PubMed] 14. Ogawa, K.; Sakakibara, H.; Iwata, R.; Ishii, T.; Sato, T.; Goda, T.; Shimoi, K.; Kumazawa, S. Anthocyanin composition and antioxidant activity of the crowberry (Empetrum nigrum) and other berries. J. Agric. Food Chem. 2008, 56, 4457–4462. [CrossRef] [PubMed] 15. Linko, R.; Karppa, J.; Kallio, H.; Ahtonen, S. Anthocyanin contents of crowberry and crowberry juice. Food Sci. Technol. 1983, 16, 343–345. 16. Törrönen, R.; McDougall, G.J.; Dobson, G.; Stewart, D.; Hellström, J.; Mattila, P.; Pihlava, J.M.; Koskela, A.; Karjalainen, R. Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects. J. Funt. Foods 2012, 4, 746–756. [CrossRef] 17. Hyun, T.K.; Kim, H.; Ko, Y.; Kim, J. Antioxidant, α-glucosidase inhibitory and anti-inflammatory effects of aerial parts extract from korean crowberry (Empetrum nigrum var. Japonicum). Saudi J. Biol. Sci. 2016, 23, 181–188. [CrossRef] [PubMed] 18. Lacramioara, O.; Ciprian, M. Antioxidants content in empetrum nigrum fresh and dried fruits. Iran. J. Public Health 2016, 45, 263–265. [PubMed] 19. Käppä, J.; Kallio, H.; Peltonen, I.; Link, R. Anthocyanins of crowberry, Empetrum nigrum coll. J. Food Sci. 1984, 49, 634–636. [CrossRef] 20. Hakkinen, S.; Heinonen, M.; Karenlampi, S.; Mykkanen, H.; Ruuskanen, J.; Torronen, R. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res. Int. 1999, 32, 345–353. [CrossRef] 21. Kähkönen, M.P.; Hopia, A.I.; Heinonen, M. Berry phenolics and their antioxidant activity. J. Agric. Food Chem. 2001, 49, 4076–4082. [CrossRef] [PubMed] 22. Dudonne, S.; Dube, P.; Anhe, F.F.; Pilon, G.; Marette, A.; Lemire, M.; Harris, C.; Dewailly, E.; Desjardins, Y. Comprehensive analysis of phenolic compounds and abscisic acid profiles of twelve native canadian berries. J. Food Compos. Anal. 2015, 44, 214–224. [CrossRef] 23. Bakowska-Barczak, A.M.; Marianchuk, M.; Kolodziejczyk, P. Survey of bioactive components in western Canadian berries. Can. J. Physiol. Pharmacol. 2007, 85, 1139–1152. [CrossRef] [PubMed] 24. Vaisanen, M.; Martz, F.; Kaarlejarvi, E.; Julkunen-Tiitto, R.; Stark, S. Phenolic responses of mountain crowberry (Empetrum nigrum ssp. hermaphroditum) to global climate change are compound specific and depend on grazing by reindeer (rangifer tarandus). J. Chem. Ecol. 2013, 39, 1390–1399. [CrossRef] [PubMed] 25. Kellogg, J.; Wang, J.; Flint, C.; Ribnicky, D.; Kuhn, P.; De Mejia, E.G.; Raskin, I.; Lila, M.A. Alaskan wild berry resources and human health under the cloud of climate change. J. Agric. Food Chem. 2010, 58, 3884–3900. [CrossRef] [PubMed] 26. Viljakainen, S.; Visti, A.; Laakso, S. Concentrations of organic acids and soluble sugars in juices from nordic berries. Acta Agric. Scand. Sect. B Soil Plant Sci. 2002, 52, 101–109. [CrossRef] 27. Mlcek, J.; Jurikova, T.; Skrovankova, S.; Sochor, J. Quercetin and its anti-allergic immune response. Molecules 2016, 21, 623. [CrossRef] [PubMed] 28. Nakajima, J.; Tanaka, I.; Seo, S.; Yamazaki, M.; Saito, K. LC/ PDA/ESI-MS profiling and radical scavenging activity of anthocyanins in various berries. J. Biomed. Biotechnol. 2004, 2004, 241–247. [CrossRef] [PubMed] 29. Heyman, L.; Axling, U.; Blanco, N.; Sterner, O.; Holm, C.; Berger, K. Evaluation of beneficial metabolic effects of berries in high-fat fed c57bl/6j mice. J. Nutr. Metab. 2014, 2014, 403041. [CrossRef] [PubMed] 30. Bae, H.S.; Kim, H.J.; Kang, J.H.; Kudo, R.; Hosoya, T.; Kumazawa, S.; Jun, M.; Kim, O.Y.; Ahn, M.R. Anthocyanin profile and antioxidant activity of various berries cultivated in Korea. Natl. Prod. Commun. 2015, 10, 963–968. 31. Koskela, A.K.; Anttonen, M.J.; Soininen, T.H.; Saviranta, N.M.; Auriola, S.; Julkunen-Tiitto, R.; Karjalainen, R.O. Variation in the anthocyanin concentration of wild populations of crowberries (Empetrum nigrum subsp. hermaphroditum). J. Agric. Food Chem. 2010, 58, 12286–12291. [CrossRef] [PubMed] 32. Hellstrom, J.; Mattila, P.; Karjalaien, R. Stability of anthocyanins in berry juices stored at different temperatures. J. Food Compos. Anal. 2013, 31, 12–19. [CrossRef] 33. Koponen, J.M.; Happonen, A.M.; Mattila, P.H.; Törrönen, A.R. Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J. Agric. Food Chem. 2007, 55, 1612–1619. [CrossRef] [PubMed] 34. Kallio, H.; Pallasaho, S.; Karppa, J.; Linko, R.R. Comparison of the half-lives of the anthocyanins in the juice of crowberry, Empetrum nigrum. J. Food Sci. 1986, 51, 408–410. [CrossRef] 35. Antioxidant Methodology: In Vivo and In Vitro Concepts; Aruoma, O.I.; Cuppet, S.L. (Eds.) AOCS Press: Champaign, IL, USA, 1997; p. 241. 36. Akasbi, M.; Shoeman, W.D.; Csallany, A.S. High performance liquid chromatography of selected phenolic compounds in olive oils. J. Am. Oil Chem. Soc. 1993, 70, 367–370. [CrossRef] 37. Gazdik, Z.; Reznicek, V.; Adam, V.; Zitka, O.; Jurikova, T.; Krska, B.; Matuskovic, J.; Plsek, J.; Saloun, J.; Horna, A.; et al. Use of Liquid Chromatography with Electrochemical Detection for the Determination of Antioxidants in Less Common Fruits. Molecules 2008, 13, 2823–2836. [CrossRef] [PubMed] 38. Gazdik, Z.; Zitka, O.; Reznicek, V.; Adam, V.; Krska, B.; Plsek, J.; Jurikova, T.; Saloun, J.; Babula, P.; Kizek, R. Utilization of HPLC-ED techniques for the screening of functional foods from resources of biodiversity. Agriculture 2009, 55, 80–87. 39. Sochor, J.; Ryvolova, M.; Krystofova, O.; Salas, P.; Hubalek, J.; Adam, V.; Trnkova, L.; Havel, L.; Beklova, M.; Zehnalek, J.; et al. Fully automated spectrometric protocols for determination of antioxidant activity: Advantages and disadvantages. Molecules 2010, 15, 8618–8640. [CrossRef] [PubMed] 40. Kim, K.C.; Lee, I.K.; Kang, K.A.; Kim, D.; Moon, J.Y.; Yoo, B.S.; Hyun, J.W. Empetrum nigrum var. japonicum extract suppresses γ-ray radiation-induced cell damage via inhibition of oxidative stress. Am. J. Chin. Med. 2011, 39, 161–170. [CrossRef] [PubMed] 41. Kim, K.C.; Kim, D.; Kim, S.C.; Jung, E.; Park, D.; Hyun, J.W. Empetrum nigrum var. japonicum extract suppresses ultraviolet B-induced cell damage via absorption of radiation and inhibition of oxidative stress. Evid. Based Complement. Altern. Med. 2013, 983609. 42. Halvorsen, B.L.; Carlsen, M.H.; Phillips, K.M.; Bøhn, S.K.; Holte, K.; Jacobs, D.R., Jr.; Blomhoff, R. Content of redox-active compounds in foods consumed in US. Am. J. Clin. Nutr. 2006, 84, 95–135. [PubMed] 43. Ermilova, E.V.; Kadyrova, T.V.; Krasnov, E.A.; Khazanov, V.A.; Il'yushenko, S.V.; Pisareva, S.I. Dense crowberry extract: Production technology, antioxidant and antihypoxant activity. Pharma.Chem. J. 2011, 35, 610–612. [CrossRef] 44. Park, S.Y.; Lee, S.P. Effectiveness of crowberry on plasma total antioxidant status, lipid profile and homocysteine. J. Food Nutr. Res. 2013, 1, 37–41. 45. Matsuura, H.; Saxena, G.; Farmer, S.W.; Hancock, R.E.; Towers, G.H. Antibacterial and antifungal compounds from Empetrum nigrum. Planta Med. 1995, 61, 256–269. [CrossRef] [PubMed] 46. Liisa, J.N.; Alakomi, H.L.; Kähkönen, M.P.; Heinonen, M.; Helander, I.M.; Oksman-Caldentey, K.M.; Puupponen-Pimiä, R.H. Berry phenolics: Antimicrobial properties and mechanisms of action against severe human pathogens. Nutr. Cancer 2006, 54, 18–32. 47. Rauha, J.P.; Remes, S.; Heinonen, M.; Hopia, A.; Kähkönen, M. Antimicrobial effects of finnish plant extracts containing flavonoids and other phenolic compounds. Int. J. Food Microbiol. 2000, 56, 3–12. [CrossRef] 48. Paudel, A.; Kaneko, K.; Watanabe, A.; Shigeki, M.; Motomu, K.; Hamamoto, H. Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents. J. Antibiot. 2014, 67, 663–667. [CrossRef] 49. Huttunen, S.; Toivanen, M.; Arkko, S.; Ruponen, M.; Tikkanen-Kaukanen, C. Inhibition activity of wild berry juice fractions against Streptococcus pneumoniae binding to human bronchial cells. Phytother. Res. 2011, 25, 122–127. [CrossRef] [PubMed] 50. Gordien, A.Y.; Gray, A.I.; Ingleby, K.; Franzblau, S.G.; Seidel, V. Activity of scottish plant, lichen and fungal endophyte extracts against mycobacterium aurum and mycobacterium tuberculosis. Phytother. Res. 2010, 24, 692–698. [PubMed] 51. Krasnov, E.A.; Ermilova, E.V.; Kadyrova, T.V.; Raldugin, V.A.; Bagryanskaya, I.Y.; Gatilov, Y.V.; Druganov, A.G.; Semenov, A.A.; Tolstikov, G.A. Phenolic components of Empetrum nigrum extract and the crystal structure of one of them. Chem. Nat. Compd. 2000, 36, 493–496. [CrossRef] 52. Li, H.; Jean, S.; Webster, D.; Robichaud, G.A.; Calhoun, L.A.; Johnson, J.A.; Gray, C.A. Dibenz[b,f]oxepin and antimycobacterial chalcone constituents of Empetrum nigrum. J. Nat. Prod. 2015, 78, 2837–2840. [CrossRef] [PubMed] 53. Heinonen, I.M.; Meyer, A.S.; Frankel, E.N. Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation. J. Agric. Food Chem. 1998, 46, 4107–4112. [CrossRef] 54. Eiro, M.; Hopia, A.; Kaukovirta-Norja, A.; Lehtinen, P.; Heinonen, M. Enhancing the colour of blackcurrant wine by natural additives. Vitic. Enol. Sci. 2000, 55, 3–6. 55. Eiro, M.J.; Heinonen, M. Anthocyanin colour behavior and stability during storage: Effect on intermolecular copigmentation. J. Agric. Food Chem. 2002, 50, 7461–7466. [CrossRef] [PubMed] 56. Rein, M.J.; Heinonen, M. Stability and enhancement of berry juice colour. J. Agric. Food Chem. 2004, 52, 3106–3114. [CrossRef] [PubMed] 57. Handbook of Functional Beverages and Human Health; Shaddi, F.; Alasalvar, C. (Eds.) CRC Press: Boca Raton, FL, USA, 2016; p. 860.
utb.fulltext.sponsorship This research was supported by the internal grant of TBU in Zlín No. IGA/FT/2016/008, IGA 11/2016/591 ZF MENDELU and KEGA 038SPU-4/2014.
utb.fulltext.projects IGA/FT/2016/008
utb.fulltext.projects IGA 11/2016/591
utb.fulltext.projects ZF MENDELU
utb.fulltext.projects KEGA 038SPU-4/2014
Find Full text

Files in this item

Show simple item record

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International