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Low molecular weight poly(lactic acid) microparticles for controlled release of the herbicide metazachlor: Preparation, morphology, and release kinetics

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dc.title Low molecular weight poly(lactic acid) microparticles for controlled release of the herbicide metazachlor: Preparation, morphology, and release kinetics en
dc.contributor.author Stloukal, Petr
dc.contributor.author Kucharczyk, Pavel
dc.contributor.author Sedlařík, Vladimír
dc.contributor.author Bažant, Pavel
dc.contributor.author Koutný, Marek
dc.relation.ispartof Journal of Agricultural and Food Chemistry
dc.identifier.issn 0021-8561 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2012
utb.relation.volume 60
utb.relation.issue 16
dc.citation.spage 4111
dc.citation.epage 4119
dc.type article
dc.language.iso en
dc.publisher American Chemical Society (ACS) en
dc.identifier.doi 10.1021/jf300521j
dc.relation.uri http://pubs.acs.org/doi/abs/10.1021/jf300521j
dc.subject controlled release en
dc.subject kinetics en
dc.subject metazachlor en
dc.subject microparticles en
dc.subject oil-in-water solvent evaporation technique en
dc.subject poly(lactic acid) en
dc.description.abstract The preemergence chloroacetamide herbicide metazachlor was encapsulated in biodegradable low molecular weight poly(lactic acid) micro- and submicroparticles, and its release to the water environment was investigated. Three series of particles, S, M, and L, varying in their size (from 0.6 to 8 μm) and with various initial amounts of the active agent (5%, 10%, 20%, 30% w/w) were prepared by the oil-in-water solvent evaporation technique with gelatin as biodegradable surfactant. The encapsulation efficiencies reached were about 60% and appeared to be lower for smaller particles. Generally, it was found that the rate of herbicide release decreased with increasing size of particles. After 30 days the portions of the herbicide released for its highest loading (30% w/w) were 92%, 56%, and 34% for about 0.6, 0.8, and 8 μm particles, respectively. The release rates were also lower for lower herbicide loadings. Metazachlor release from larger particles tended to be a diffusion-controlled process, while for smaller particles the kinetics was strongly influenced by an initial burst release. © 2012 American Chemical Society. en
utb.faculty Faculty of Technology
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1002802
utb.identifier.rivid RIV/70883521:28110/12:43867835!RIV13-MSM-28110___
utb.identifier.rivid RIV/70883521:28610/12:43867835!RIV13-MSM-28610___
utb.identifier.obdid 43867923
utb.identifier.scopus 2-s2.0-84860319905
utb.identifier.wok 000303139600018
utb.identifier.coden JAFCA
utb.source j-scopus
dc.date.accessioned 2012-06-04T11:34:10Z
dc.date.available 2012-06-04T11:34:10Z
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Stloukal, Petr
utb.contributor.internalauthor Kucharczyk, Pavel
utb.contributor.internalauthor Sedlařík, Vladimír
utb.contributor.internalauthor Bažant, Pavel
utb.contributor.internalauthor Koutný, Marek
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