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Nonlinear oscillatory shear tests of pressure-sensitive adhesives (PSAs) designed for transdermal therapeutic systems (TTS)

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dc.title Nonlinear oscillatory shear tests of pressure-sensitive adhesives (PSAs) designed for transdermal therapeutic systems (TTS) en
dc.contributor.author Meurer, Michael
dc.contributor.author Kádár, Roland
dc.contributor.author Ramakers-van Dorp, Esther
dc.contributor.author Möginger, Bernhard
dc.contributor.author Hausnerová, Berenika
dc.relation.ispartof Rheologica Acta
dc.identifier.issn 0035-4511 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2021
dc.type article
dc.language.iso en
dc.publisher Springer
dc.identifier.doi 10.1007/s00397-021-01280-6
dc.relation.uri https://link.springer.com/article/10.1007/s00397-021-01280-6
dc.subject pressure-sensitive adhesive en
dc.subject transdermal therapeutic system en
dc.subject viscoelastic behavior en
dc.subject nonlinear coefficient en
dc.subject strain stiffening en
dc.subject shear thickening en
dc.description.abstract Transdermal therapeutic systems (TTS) based on pressure-sensitive adhesives (PSAs) allow for the application of pharmaceutical substances via diffusion through the skin. The rheological performance of PSA is largely investigated within small amplitude oscillatory shear (typically up to 1 %), although the skin motions exceed strains beyond 40 %. In this paper, amine-compatible (AC) and non-amine-compatible (NAC) silicone-based PSA compounds differing in the resin content were subjected to strain amplitude sweeps in a twin drive rheometer. Carreau-Yasuda-like fitting of storage and loss moduli curves intercepts the substantial effect of resin content on both compounds; up to four times higher, moduli of AC compounds were determined in SAOS, and their higher molecular mass combined with enhanced interactions contributed to an earlier transition to the nonlinear viscoelastic region. In the nonlinear range, elastic and viscous properties are affected by strains in a different manner with the trend favorable for the PSA application as TTS. The third relative higher harmonic from Fourier transformation I-3/1 as well as intra-cycle strain stiffening and shear thickening ratios provide information relevant for an optimization of PSA subjected to large deformations. en
utb.faculty Faculty of Technology
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1010452
utb.identifier.obdid 43883058
utb.identifier.scopus 2-s2.0-85110872944
utb.identifier.wok 000675036000002
utb.source J-wok
dc.date.accessioned 2021-08-10T07:48:38Z
dc.date.available 2021-08-10T07:48:38Z
dc.description.sponsorship German Ministry of Education and ResearchFederal Ministry of Education & Research (BMBF) [03FH039PX5]; Graduate Institute Bonn-Rhein-Sieg University of Applied Sciences; ERASMUS+ at the TBU in Zlin
dc.description.sponsorship RP/CPS/2020/003; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Bundesministerium für Bildung und Forschung, BMBF: 03FH039PX5; Chalmers Tekniska Högskola
utb.ou Dept Prod Engn
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Meurer, Michael
utb.contributor.internalauthor Hausnerová, Berenika
utb.fulltext.sponsorship This study was supported by the German Ministry of Education and Research, Grant No. 03FH039PX5. The author M.M. also thanks the Graduate Institute Bonn-Rhein-Sieg University of Applied Sciences for supporting this work by granting a scholarship. Special thanks goes to ERASMUS+ at the TBU in Zlin for the financial support enabling a research semester at the Chalmers University of Technology, Gothenburg, Sweden.
utb.wos.affiliation [Meurer, Michael; Ramakers-van Dorp, Esther; Moeginger, Bernhard] Univ Appl Sci Bonn Rhein Sieg, Dept Nat Sci, Von Liebig Str 20, D-53359 Rheinbach, Germany; [Meurer, Michael; Hausnerova, Berenika] Tomas Bata Univ Zlin, Fac Technol, Dept Prod Engn, Vavreckova 275, Zlin 76001, Czech Republic; [Kadar, Roland] Chalmers Univ Technol, Dept Ind & Mat Sci, SE-41296 Gothenburg, Sweden; [Hausnerova, Berenika] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, TG Masaryka 5555, Zlin 76001, Czech Republic
utb.scopus.affiliation Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, Von-Liebig-Str. 20, Rheinbach, D-53359, Germany; Department of Production Engineering, Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, Zlín, 76001, Czech Republic; Department of Industrial and Materials Science, Chalmers University of Technology, Gothenburg, SE-41296, Sweden; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Nam. T.G. Masaryka 5555, Zlín, 76001, Czech Republic
utb.fulltext.projects 03FH039PX5
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