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Thin films of cross-linked polylactic acid as tailored platforms for controlled drug release

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dc.title Thin films of cross-linked polylactic acid as tailored platforms for controlled drug release en
dc.contributor.author Krtouš, Zdeněk
dc.contributor.author Kousal, J.
dc.contributor.author Sedlaříková, Jana
dc.contributor.author Kolářová Rašková, Zuzana
dc.contributor.author Kučerová, Liliana
dc.contributor.author Krakovský, Ivan
dc.contributor.author Kučera, Jaromír
dc.contributor.author Ali-Ogly, Suren
dc.contributor.author Pleskunov, Pavel
dc.contributor.author Choukourov, Andrei
dc.relation.ispartof Surface and Coatings Technology
dc.identifier.issn 0257-8972 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2021
utb.relation.volume 421
dc.type article
dc.language.iso en
dc.publisher Elsevier B.V.
dc.identifier.doi 10.1016/j.surfcoat.2021.127402
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0257897221005764
dc.subject plasma polymerization en
dc.subject plasma-assisted vapour thermal deposition en
dc.subject polylactic acid en
dc.subject biodegradability en
dc.subject controlled drug release en
dc.description.abstract Drug-loaded polymers are desirable for the controlled administration of bioactive molecules to biological media because polymer viscoelasticity can be translated into benefits of tissue-contacting materials. Here, we report on plasma-assisted deposition of polyester thin films performed via thermal evaporation of polylactic acid (PLA). The films can be produced with the chemical composition and polymer topology precisely tuned by the discharge power. At low power, weakly cross-linked films are produced with the chemical motif resembling that of PLA, the molar mass distribution peaking at ~350 g × mol−1 and skewing to larger species. At high power, highly cross-linked films are produced with a worse resemblance to PLA. The films swell and dissolve in water, releasing oligomers with the dissolution kinetics spanning over a broad time scale of 10−1–104 s. The released oligomers undergo hydrolysis at the time scale of days and with the final product of lactic acid, meeting the biocompatibility demands. When dissolving, the films expose micrometre-sized pores or buckling instabilities, depending on the discharge power. The phenomenon can be used for controlled release of nisin, an antibacterial peptide so that an hour-delayed release is achieved via the pore-mediated diffusion, whereas a minute-delayed release is achieved through the buckling. Nisin-loaded polyester plasma polymer films are effective against Micrococcus luteus, the bactericidal activity correlating with the drug release kinetics. Hence, the film design holds promise for developing advanced wound dressing materials and other tissue-contacting devices with tunable therapeutic effect. © 2021 Elsevier B.V. en
utb.faculty Faculty of Technology
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1010384
utb.identifier.scopus 2-s2.0-85108403120
utb.identifier.wok 000666583900038
utb.source j-scopus
dc.date.accessioned 2021-07-01T21:14:23Z
dc.date.available 2021-07-01T21:14:23Z
dc.description.sponsorship Czech Science FoundationGrant Agency of the Czech Republic [GA17-10813S]; Charles University [SVV 260 579/2021]; Ministry of Industry and Trade of the Czech Republic [TRIO FV10400]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Sedlaříková, Jana
utb.contributor.internalauthor Kolářová Rašková, Zuzana
utb.contributor.internalauthor Kučerová, Liliana
utb.fulltext.sponsorship The research was chiefly funded by the Czech Science Foundation through the grant GA17-10813S . The Charles University's financial support via the student grant SVV 260 579/2021 and support from the Ministry of Industry and Trade of the Czech Republic via the project TRIO FV10400 are also acknowledged.
utb.wos.affiliation [Krtous, Zdenek; Kousal, Jaroslav; Krakovsky, Ivan; Ali-Ogly, Suren; Pleskunov, Pavel; Choukourov, Andrei] Charles Univ Prague, Fac Math & Phys, V Holesovickach 2, Prague 18000, Czech Republic; [Kousal, Jaroslav; Kucera, Jaromir] Czech Tech Univ, Fac Mech Engn, Karlovo Namesti 13, Prague 12135, Czech Republic; [Sedlarikova, Jana; Kucerova, Liliana] Tomas Bata Univ Zlin, Fac Technol, Vavreckova 275, Zlin, Czech Republic; [Sedlarikova, Jana; Raskova, Zuzana Kolarova; Kucerova, Liliana] Tomas Bata Univ Zlin, Ctr Polymer Syst, Trida Tomarse Bati 5678, Zlin 76001, Czech Republic
utb.scopus.affiliation Faculty of Mathematics and Physics, Charles University, V Holešovickách 2, Prague, 180 00, Czech Republic; Faculty of Mechanical Engineering, Czech Technical University in Prague, Karlovo náměstí 13, Prague, 121 35, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, Zlín, 76001, Czech Republic; Centre of Polymer Systems, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, Zlín, 76001, Czech Republic
utb.fulltext.projects GA17-10813S
utb.fulltext.projects SVV 260 579/2021
utb.fulltext.projects TRIO FV10400
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