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Nanoparticle-based rifampicin delivery system development

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dc.title Nanoparticle-based rifampicin delivery system development en
dc.contributor.author Motiei, Marjan
dc.contributor.author Pleno de Gouveia, Luis
dc.contributor.author Šopík, Tomáš
dc.contributor.author Vícha, Robert
dc.contributor.author Škoda, David
dc.contributor.author Císař, Jaroslav
dc.contributor.author Khalili, Reza
dc.contributor.author Domincová Bergerová, Eva
dc.contributor.author Münster, Lukáš
dc.contributor.author Fei, Haojie
dc.contributor.author Sedlařík, Vladimír
dc.contributor.author Sáha, Petr
dc.relation.ispartof Molecules
dc.identifier.issn 1420-3049 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2021
utb.relation.volume 26
utb.relation.issue 7
dc.type article
dc.language.iso en
dc.publisher MDPI
dc.identifier.doi 10.3390/molecules26072067
dc.relation.uri https://www.mdpi.com/1420-3049/26/7/2067
dc.subject rifampicin en
dc.subject polyelectrolyte nanoparticles en
dc.subject ascorbic acid en
dc.subject alkaline pH en
dc.description.abstract The alkaline milieu of chronic wounds severely impairs the therapeutic effect of antibiotics, such as rifampicin; as such, the development of new drugs, or the smart delivery of existing drugs, is required. Herein, two innovative polyelectrolyte nanoparticles (PENs), composed of an amphiphilic chitosan core and a polycationic shell, were synthesized at alkaline pH, and in vitro performances were assessed by H-1 NMR, elemental analysis, FT-IR, XRD, DSC, DLS, SEM, TEM, UV/Vis spectrophotometry, and HPLC. According to the results, the nanostructures exhibited different morphologies but similar physicochemical properties and release profiles. It was also hypothesized that the simultaneous use of the nanosystem and an antioxidant could be therapeutically beneficial. Therefore, the simultaneous effects of ascorbic acid and PENs were evaluated on the release profile and degradation of rifampicin, in which the results confirmed their synergistic protective effect at pH 8.5, as opposed to pH 7.4. Overall, this study highlighted the benefits of nanoparticulate development in the presence of antioxidants, at alkaline pH, as an efficient approach for decreasing rifampicin degradation. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1010307
utb.identifier.scopus 2-s2.0-85105223223
utb.identifier.wok 000638730400001
utb.source J-wok
dc.date.accessioned 2021-04-30T19:22:35Z
dc.date.available 2021-04-30T19:22:35Z
dc.description.sponsorship Ministry of Education, Youth and Sport of the Czech Republic-DKRVO [RP/CPS/2020/005]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Motiei, Marjan
utb.contributor.internalauthor Šopík, Tomáš
utb.contributor.internalauthor Vícha, Robert
utb.contributor.internalauthor Škoda, David
utb.contributor.internalauthor Císař, Jaroslav
utb.contributor.internalauthor Domincová Bergerová, Eva
utb.contributor.internalauthor Münster, Lukáš
utb.contributor.internalauthor Fei, Haojie
utb.contributor.internalauthor Sedlařík, Vladimír
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.sponsorship This project was supported by the Ministry of Education, Youth and Sport of the Czech Republic- DKRVO (RP/CPS/2020/005).
utb.wos.affiliation [Motiei, Marjan; Sopik, Tomas; Skoda, David; Cisar, Jaroslav; Domincova Bergerova, Eva; Munster, Lukas; Fei, Haojie; Sedlarik, Vladimir; Saha, Petr] TBU, Univ Inst, Ctr Polymer Syst, Tr Tomase Bati 5678, Zlin 76001, Czech Republic; [Pleno de Gouveia, Luis] Univ Lisbon, iMed ULisboa, Fac Pharm, P-169003 Lisbon, Portugal; [Vicha, Robert] TBU, Fac Technol, Dept Chem, Vavreckova 275, Zlin 76001, Czech Republic; [Khalili, Reza] Charles Univ Prague, Fac Med 1, Dept Paediat & Inherited Metab Disorders, Ke Karlovu 455-2, Prague 12808 2, Czech Republic; [Khalili, Reza] Gen Univ Hosp Prague, Ke Karlovu 455-2, Prague 12808 2, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, University Institute, tr. Tomase Bati 5678Zlin 76001, Czech Republic; iMed.ULisboa, Faculty of Pharmacy, Universidade de LisboaLisbon 169-003, Portugal; Department of Chemistry, Faculty of Technology, Vavrečkova 27576001 Zlín, Czech Republic; Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 455/2, 12808 Prague 2, Czech Republic
utb.fulltext.projects RP/CPS/2020/005
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