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Redox-sensitive and hyaluronic acid-functionalized nanoparticles for improving breast cancer treatment by cytoplasmic 17α-methyltestosterone delivery

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dc.title Redox-sensitive and hyaluronic acid-functionalized nanoparticles for improving breast cancer treatment by cytoplasmic 17α-methyltestosterone delivery en
dc.contributor.author Rezaei, Somayeh
dc.contributor.author Kashanian, Soheila
dc.contributor.author Bahrami, Yadollah
dc.contributor.author Cruz, Luis J.
dc.contributor.author Motiei, Marjan
dc.relation.ispartof Molecules
dc.identifier.issn 1420-3049 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 25
utb.relation.issue 5
dc.type article
dc.language.iso en
dc.publisher MDPI AG
dc.identifier.doi 10.3390/molecules25051181
dc.relation.uri https://www.mdpi.com/1420-3049/25/5/1181
dc.subject reduction-responsive nanoparticles en
dc.subject hyaluronic acid en
dc.subject chitosan en
dc.subject lipoic acid en
dc.subject CD44 en
dc.subject 17 alpha-methyltestosterone en
dc.description.abstract Novel reduction-responsive hyaluronic acid-chitosan-lipoic acid nanoparticles (HACSLA-NPs) were designed and synthesized for effective treatment of breast cancer by targeting Cluster of Differentiation 44 (CD44)-overexpressing cells and reduction-triggered 17α- Methyltestosterone (MT) release for systemic delivery. The effectiveness of these nanoparticles was investigated by different assays, including release rate, 3-(4,5-Dimethylthiazol-2-Yl)-2,5- Diphenyltetrazolium Bromide (MTT), lactate dehydrogenase (LDH), caspase-3 activity, Rhodamine 123 (RH-123), and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). In vitro experiments revealed that Methyltestosterone/Hyaluronic acid-chitosan-lipoic acid nanoparticles (MT/HACSLA-NPs) illustrated a sustained drug release in the absence of glutathione (GSH), while the presence of GSH led to fast MT release. HACSLA-NPs also showed high cellular internalization via CD44 receptors, quick drug release inside the cells, and amended cytotoxicity against positive CD44 BT-20 breast cancer cell line as opposed to negative CD44, Michigan Cancer Foundation-7 (MCF-7) cell line. These findings supported that these novel reduction-responsive NPs can be promising candidates for efficient targeted delivery of therapeutics in cancer therapy. © 2020 by the authors. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009619
utb.identifier.obdid 43881901
utb.identifier.scopus 2-s2.0-85081225239
utb.identifier.wok 000529219900164
utb.identifier.pubmed 32151062
utb.identifier.coden MOLEF
utb.source j-scopus
dc.date.accessioned 2020-03-26T10:44:53Z
dc.date.available 2020-03-26T10:44:53Z
dc.description.sponsorship European Commission H2020-MSCA-RISE [644373-PRISAR, 777682-CANCER]; European Commission H2020-WIDESPREAD-05-2017-Twinning [807281-ACORN]; European Commission H2020-WIDESPREAD-2018-03 [852985-SIMICA]; European Commission H2020-SCA-RISE-2016 [734684-CHARMED]; European Commission MSCA-ITN-2015-ETN [675743-ISPIC]; European CommissionEuropean Commission Joint Research Centre [861190, 857894, 859908, 860173, 872860]; VIDI personal grant [723.012.110]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Motiei, Marjan
utb.fulltext.affiliation Somayeh Rezaei 1,2, Soheila Kashanian 1,3*, Yadollah Bahrami 4,5,6, Luis J. Cruz 2*, Marjan Motiei 7 1 Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran 2 Translational Nanobiomaterials and Imaging, department of Radiology, Leiden University Medical Centre (LUMC), 2333 ZA Leiden, The Netherlands 3 Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran 4 Department of Medical Biotechnology, School of Medicine, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia 5 Department of Pharmacognosy & Pharmaceutical Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6714415153, Iran 6 Molecular Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran 7 Centre of Polymer Systems, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, 76001 Zlín, Czech Republic * Authors to whom correspondence should be addressed.
utb.fulltext.dates Received: 6 February 2020 Revised: 24 February 2020 Accepted: 25 February 2020 Published: 5 March 2020
utb.fulltext.sponsorship Funding: This work was supported by project grants from the European Commission H2020-MSCA-RISE (644373 - PRISAR), H2020-MSCA-RISE (777682 - CANCER), H2020-WIDESPREAD-05-2017-Twinning (807281 - ACORN), H2020-WIDESPREAD-2018-03 (852985 - SIMICA), H2020-SCA-RISE-2016 (734684 - CHARMED) and MSCA-ITN-2015-ETN (675743 - ISPIC), 861190 (PAVE), 857894 (CAST), 859908 (NOVA-MRI); 860173 (RISE-WELL); 872860 (PRISAR2). This work was also financially supported by the VIDI personal grant (project number 723.012.110) L.J.C.
utb.wos.affiliation [Rezaei, Somayeh; Kashanian, Soheila] Razi Univ, Fac Chem, Dept Appl Chem, Kermanshah 6714414971, Iran; [Rezaei, Somayeh; Cruz, Luis J.] LUMC, Dept Radiol, Translat Nanobiomat & Imaging, Leiden 2333 ZA, Netherlands; [Kashanian, Soheila] Kermanshah Univ Med Sci, Nano Drug Delivery Res Ctr, Kermanshah 6734667149, Iran; [Bahrami, Yadollah] Flinders Univ S Australia, Coll Med & Publ Hlth, Sch Med, Dept Med Biotechnol, Bedford Pk, SA 5042, Australia; [Bahrami, Yadollah] Kermanshah Univ Med Sci, Fac Pharm, Dept Pharmacognosy & Pharmaceut Biotechnol, Kermanshah 6714415153, Iran; [Bahrami, Yadollah] Kermanshah Univ Med Sci, Mol Biol Res Ctr, Kermanshah 6714415185, Iran; [Motiei, Marjan] Tomas Bata Univ Zlin, Ctr Polymer Syst, Trida Tomase Bati 5678, Zlin 76001, Czech Republic
utb.scopus.affiliation Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, 6714414971, Iran; Translational Nanobiomaterials and Imaging, Department of Radiology, Leiden University Medical Centre (LUMC), Leiden, 2333 ZA, Netherlands; Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran; Department of Medical Biotechnology, School of Medicine, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia; Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6714415153, Iran; Molecular Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, 6714415185, Iran; Centre of Polymer Systems, Tomas Bata University in Zlín, Trída Tomáse Bati 5678, Zlín, 76001, Czech Republic
utb.fulltext.projects H2020-MSCA-RISE
utb.fulltext.projects 644373 - PRISAR
utb.fulltext.projects H2020-MSCA-RISE
utb.fulltext.projects 777682 - CANCER
utb.fulltext.projects H2020-WIDESPREAD-05-2017-Twinning
utb.fulltext.projects 807281 - ACORN
utb.fulltext.projects H2020-WIDESPREAD-2018-03
utb.fulltext.projects 852985 - SIMICA
utb.fulltext.projects H2020-SCA-RISE-2016
utb.fulltext.projects 734684 - CHARMED
utb.fulltext.projects MSCA-ITN-2015-ETN
utb.fulltext.projects 675743 - ISPIC
utb.fulltext.projects 861190
utb.fulltext.projects 857894
utb.fulltext.projects 859908
utb.fulltext.projects 860173
utb.fulltext.projects 872860
utb.fulltext.projects 723.012.110
utb.fulltext.ou Centre of Polymer Systems
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