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Mussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability

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dc.title Mussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability en
dc.contributor.author Mrlík, Miroslav
dc.contributor.author Špírek, Mário
dc.contributor.author Al-Khori, Jassim
dc.contributor.author Ahmad, Ali Abdulrahman
dc.contributor.author Mosnaček, Jaroslav
dc.contributor.author AlMaadeed, Mariam AlAli
dc.contributor.author Kasák, Peter
dc.relation.ispartof Arabian Journal of Chemistry
dc.identifier.issn 1878-5352 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 13
utb.relation.issue 1
dc.citation.spage 193
dc.citation.epage 204
dc.type article
dc.language.iso en
dc.publisher Elsevier B.V.
dc.identifier.doi 10.1016/j.arabjc.2017.03.009
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1878535217300679
dc.subject Polysulfobetaine en
dc.subject Metal coordination en
dc.subject Antibacterial en
dc.subject Self-healing en
dc.subject Hydrogels en
dc.subject Catecholamine polymers en
dc.description.abstract In the present study, the sulfobetaine-based copolymer bearing a dopamine functionality showed gel formation adjusted by the application of metal salts for gelation and various values of pH. Normally, the liquid-like solution of the sulfobetaine-based copolymer and metal cross-linkers is transformed to a gel-like state upon increasing the pH values in the presence of Fe3+ and Ti3+. Metal-induced coordination is reversible by means of the application of EDTA as a chelating agent. In the case of Ag+ ions, the gel is formed through a redox process accompanied with the oxidative coupling of the dopamine moieties and Ag0 particle formation. Mussel-mimicking and metal-dependent viscoelastic properties were observed for Fe3+, Ti3+, and Ag+ cross-linking agents, with additionally enhanced self-healing behavior in comparison with the covalently cross-linked IO4 − analogues. Antibacterial properties can be achieved both in solution and on the surface using the proper concentration of Ag+ ions used for gelation; thus, a tunable amount of the Ag0 particles are formed in the hydrogel. The cytotoxicity was elucidated by the both MTT assay on the NIH/3T3 fibroblast cell line and direct contact method using human dermal fibroblast cell (F121) and shows the non-toxic character of the synthesized copolymer. © 2017 The Authors en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009513
utb.identifier.obdid 43881941
utb.identifier.scopus 2-s2.0-85018624215
utb.identifier.wok 000505076000018
utb.source j-scopus
dc.date.accessioned 2020-01-09T10:31:41Z
dc.date.available 2020-01-09T10:31:41Z
dc.description.sponsorship Qatar University [QUUG-CAM-2017-1]; Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]; Maersk Oil R&TC Qatar project; Qatar National Research Fund (Qatar Foundation) [9 - 219-2-105]
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Mrlík, Miroslav
utb.fulltext.affiliation Miroslav Mrlík a*, Mário Špírek b, Jassim Al-Khori c, Ali Abdulrahman Ahmad c, Jaroslav Mosnaček d, Mariam AlAli AlMaadeed e, Peter Kasák f* a Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic b Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic c Maersk Oil Research and Technical Center, Doha, Qatar d Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, 84541 Bratislava, Slovakia e Materials Science and Technology Program, Qatar University, P.O. BOX 2713, Doha, Qatar f Center for Advanced Materials, Qatar University, P.O. BOX 2713, Doha, Qatar * Corresponding authors. E-mail addresses: mrlik@cps.utb.cz (M. Mrlík), peter.kasak@qu.edu.qa (P. Kasák).
utb.fulltext.dates Received 3 January 2017 accepted 19 March 2017 Available online 24 March 2017
utb.fulltext.sponsorship P.K. gratefully acknowledge Qatar University internal grant QUUG-CAM-2017-1. This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic ? Program NPU I (LO1504). This work was also supported by the Maersk Oil R&TC Qatar project. This work was also made possible by NPRP grant # 9 ? 219-2-105 from the Qatar National Research Fund (A Member of The Qatar Foundation). The finding achieved herein is solely the responsibility of the authors.
utb.wos.affiliation [Mrlik, Miroslav] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Trida T Bati 5678, Zlin 76001, Czech Republic; [Spirek, Mario] Masaryk Univ, Fac Med, Dept Biol, Brno 62500, Czech Republic; [Al-Khori, Jassim; Ahmad, Ali Abdulrahman] Maersk Oil Res & Tech Ctr, Doha, Qatar; [Mosnacek, Jaroslav] Slovak Acad Sci, Polymer Inst, Dubravska Cesta 9, Bratislava 84541, Slovakia; [AlMaadeed, Mariam Alali] Qatar Univ, Mat Sci & Technol Program, POB 2713, Doha, Qatar; [Kasak, Peter] Qatar Univ, Ctr Adv Mat, POB 2713, Doha, Qatar
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida T. Bati 5678, Zlin, 760 01, Czech Republic; Department of Biology, Faculty of Medicine, Masaryk University, Brno, 62500, Czech Republic; Maersk Oil Research and Technical Center, Doha, Qatar; Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, 84541, Slovakia; Materials Science and Technology Program, Qatar University, P.O. BOX 2713, Doha, Qatar; Center for Advanced Materials, Qatar University, P.O. BOX 2713, Doha, Qatar
utb.fulltext.projects QUUG-CAM-2017-1
utb.fulltext.projects LO1504
utb.fulltext.projects 9-219-2-105
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
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