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Synthesis and characterization of a bioartificial polymeric system with potential antibacterial activity: Chitosan-polyvinyl alcohol-ampicillin

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dc.title Synthesis and characterization of a bioartificial polymeric system with potential antibacterial activity: Chitosan-polyvinyl alcohol-ampicillin en
dc.contributor.author Bernal Ballén, Andrés
dc.contributor.author López García, Jorge Andrés
dc.contributor.author Merchán-Merchán, Martha Andrea
dc.contributor.author Lehocký, Marián
dc.relation.ispartof Molecules
dc.identifier.issn 1420-3049 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2018
utb.relation.volume 23
utb.relation.issue 12
dc.type article
dc.language.iso en
dc.publisher Molecular Diversity Preservation International (MDPI)
dc.identifier.doi 10.3390/molecules23123109
dc.relation.uri https://www.mdpi.com/1420-3049/23/12/3109
dc.subject bio-artificial polymeric system en
dc.subject health-care associated infections en
dc.subject polyvinyl alcohol en
dc.subject chitosan en
dc.subject ampicillin en
dc.description.abstract Bio-artificial polymeric systems are a new class of polymeric constituents based on blends of synthetic and natural polymers, designed with the purpose of producing new materials that exhibit enhanced properties with respect to the individual components. In this frame, a combination of polyvinyl alcohol (PVA) and chitosan, blended with a widely used antibiotic, sodium ampicillin, has been developed showing a moderate behavior in terms of antibacterial properties. Thus, aqueous solutions of PVA at 1 wt.% were mixed with acid solutions of chitosan at 1 wt.%, followed by adding ampicillin ranging from 0.3 to 1.0 wt.% related to the total amount of the polymers. The prepared bio-artificial polymeric system was characterized by FTIR, SEM, DSC, contact angle measurements, antibacterial activity against Staphylococcus aureus and Escherichia coli and antibiotic release studies. The statistical significance of the antibacterial activity was determined using a multifactorial analysis of variance with ρ < 0.05 (ANOVA). The characterization techniques did not show alterations in the ampicillin structure and the interactions with polymers were limited to intermolecular forces. Therefore, the antibiotic was efficiently released from the matrix and its antibacterial activity was preserved. The system disclosed moderate antibacterial activity against bacterial strains without adding a high antibiotic concentration. The findings of this study suggest that the system may be effective against healthcare-associated infections, a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications. © 2018 by the authors. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008368
utb.identifier.obdid 43879344
utb.identifier.scopus 2-s2.0-85057506745
utb.identifier.wok 000454523000059
utb.identifier.pubmed 30486491
utb.identifier.coden MOLEF
utb.source j-scopus
dc.date.accessioned 2019-01-31T08:58:57Z
dc.date.available 2019-01-31T08:58:57Z
dc.description.sponsorship Czech Science Foundation [17-10813S]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor López García, Jorge Andrés
utb.contributor.internalauthor Lehocký, Marián
utb.wos.affiliation [Bernal-Ballen, Andres] Univ Manuela Beltran, Grp Invest Ingn Biomed, Vicerrectoria Invest, Ave Circunvalar 60-00, Bogota 1101, Colombia; [Lopez-Garcia, Jorge; Lehocky, Marian] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Trida Tomase Bati 5678, Zlin 76001, Czech Republic; [Merchan-Merchan, Martha-Andrea] Univ Antonio Narino, Calle 22 12D-81, Bogota 1101, Colombia
utb.scopus.affiliation Grupo de Investigación en Ingeniería Biomédica, Vicerrectoría de Investigaciones, Universidad Manuela Beltrán, Avenida Circunvalar No. 60-00, Bogotá, 1101, Colombia; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Trida Tomase Bati 5678, Zlín, 76001, Czech Republic; Maestría en Educación, Universidad Antonio Nariño, Conciencia, Calle 22 sur No. 12D-81, Bogotá, 1101, Colombia
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