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Behaviour of silver nanoparticles in simulated saliva and gastrointestinal fluids

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dc.title Behaviour of silver nanoparticles in simulated saliva and gastrointestinal fluids en
dc.contributor.author Pinďáková, Lucie
dc.contributor.author Kašpárková, Věra
dc.contributor.author Kejlová, Kristina
dc.contributor.author Dvořáková, Markéta
dc.contributor.author Krsek, Daniel
dc.contributor.author Jírová, Dagmar
dc.contributor.author Kašparová, Lucie
dc.relation.ispartof International Journal of Pharmaceutics
dc.identifier.issn 0378-5173 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 527
utb.relation.issue 1-2
dc.citation.spage 12
dc.citation.epage 20
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.ijpharm.2017.05.026
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0378517317304386
dc.subject Silver nanoparticles en
dc.subject Saliva en
dc.subject Simulated gastrointestinal fluids en
dc.subject Dynamic light scattering en
dc.subject Transmission electron microscopy en
dc.subject Reconstructed human tissue models en
dc.description.abstract Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust toxicological methods for evaluation of toxic potential of AgNPs and information on their physicochemical state. Silver nanoparticles were subjected to action of simulated saliva, gastric and intestinal fluids, appropriately supplemented with digestive enzymes pepsin or pancreatin. The behaviour of AgNPs was determined using dynamic light scattering and transmission electron microscopy, and their toxicity as well as capability to induce inflammatory reactions were assessed using reconstructed human tissue models (EpiOral, EpiGingival, EpiIntestinal). The study revealed that during exposure to the fluids, AgNPs size and morphology changed and depended on composition and pH of the respective fluid. If present, the change in terms of growth of AgNPs size occurred immediately after contact of AgNPs with the respective fluid and continued with prolonged time of contact. A pilot study on reconstituted human tissue models revealed low toxicity and inflammatory effects of AgNPs and confirmed the suitability of 3-D models for toxicological studies including bioavailability. © 2017 en
utb.faculty Faculty of Technology
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1007417
utb.identifier.obdid 43876563
utb.identifier.scopus 2-s2.0-85019859650
utb.identifier.wok 000404505400002
utb.identifier.pubmed 28506800
utb.identifier.coden IJPHD
utb.source j-scopus
dc.date.accessioned 2017-09-08T12:14:54Z
dc.date.available 2017-09-08T12:14:54Z
dc.description.sponsorship 17-05095S, GACR, Grantová Agentura České Republiky
dc.description.sponsorship Czech Science Foundation [17-05095S]; Ministry of Health, Czech Republic conceptual development of research organization (National Institute of Public Health - NIPH) [75010330]; TBU in Zlin; funds of specific academic research [IGA/CPS/2017/001]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Pinďáková, Lucie
utb.contributor.internalauthor Kašpárková, Věra
utb.scopus.affiliation Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlin, Nam T.G. Masaryka 5555, Zlín, Czech Republic; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida Tomase Bati 5678, Zlín, Czech Republic; National Institute of Public Health, Šrobárova 48, Prague, Czech Republic
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