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Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

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dc.title Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago en
dc.contributor.author Svobodová, Blanka
dc.contributor.author Barros, Lillian
dc.contributor.author Calhelha, Ricardo C.
dc.contributor.author Heleno, Sandrina
dc.contributor.author Alves, Maria Jose
dc.contributor.author Walcott, Simone
dc.contributor.author Bittová, Miroslava
dc.contributor.author Kubáň, Vlastimil
dc.contributor.author Ferreira, Isabel C. F. R.
dc.relation.ispartof Industrial Crops and Products
dc.identifier.issn 0926-6690 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 95
dc.citation.spage 365
dc.citation.epage 373
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.indcrop.2016.10.046
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0926669016307336
dc.subject Anti-inflammatory en
dc.subject Antimicrobial activity en
dc.subject Antioxidant en
dc.subject Cytotoxicity en
dc.subject Momordica charantia L. en
dc.subject Phenolic compounds en
dc.description.abstract A wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, β-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC50 = 10–0.625 μg/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant. © 2016 Elsevier B.V. en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1006914
utb.identifier.obdid 43877109
utb.identifier.scopus 2-s2.0-85028017390
utb.identifier.wok 000390621600042
utb.identifier.coden ICRDE
utb.source j-scopus
dc.date.accessioned 2017-06-27T08:13:14Z
dc.date.available 2017-06-27T08:13:14Z
dc.description.sponsorship FEDER, Federación Española de Enfermedades Raras
dc.description.sponsorship Foundation for Science and Technology (FCT, Portugal); FEDER [UID/AGR/00690/2013, SFRH/BPD/107855/2015, SFRH/BPD/101413/2014, SFRH/BPD/BPD/68344/2010]; FEDER under LSRE [UID/EQU/50020/2013]; Internal Grant Agency of Tomas Bata University in Zlin [IGA/FT/2016/003]
utb.contributor.internalauthor Svobodová, Blanka
utb.contributor.internalauthor Kubáň, Vlastimil
utb.fulltext.affiliation Blanka Svobodova a,b , Lillian Barros a,c,∗∗ , Ricardo C. Calhelha a , Sandrina Heleno a , Maria Jose Alves d , Simone Walcott e , Miroslava Bittova f , Vlastimil Kuban b , Isabel C.F.R. Ferreira a,∗ a Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Braganc ̧ a, Campus de Santa Apolonia, 1172, 5300-253 Braganc ̧ a, Portugal b Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 275, 762 72 Zlin, Czechia c Laboratory of Separation and Reaction Engineering – Laboratory of Catalysis and Materials (LSRE-LCM), Polytechnic Institute of Braganc ̧ a, Campus de Santa Apolonia, 1134, 5301-857 Braganc ̧ a, Portugal d Escola Superior de Saúde, Instituto Politécnico de Braganc ̧ a, Av. D. Afonso V, 5300-121 Braganc ̧ a, Portugal e Faculty of Science and Technology, University of West Indies, St Augustine Campus, Trinidad and Tobago f Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czechia
utb.fulltext.dates Received 23 June 2016 Received in revised form 19 September 2016 Accepted 26 October 2016 Available online 28 October 2016
utb.fulltext.sponsorship The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013), LSRE (Project UID/EQU/50020/2013), L. Barros (SFRH/BPD/107855/2015), S. Heleno (SFRH/BPD/101413/2014) and R.C. Calhelha (SFRH/BPD/BPD/68344/2010) grants. This study was financially supported by Internal Grant Agency of Tomas Bata University in Zlin, project Nr. IGA/FT/2016/003.
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