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dc.title | Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago | en |
dc.contributor.author | Svobodová, Blanka | |
dc.contributor.author | Barros, Lillian | |
dc.contributor.author | Calhelha, Ricardo C. | |
dc.contributor.author | Heleno, Sandrina | |
dc.contributor.author | Alves, Maria Jose | |
dc.contributor.author | Walcott, Simone | |
dc.contributor.author | Bittová, Miroslava | |
dc.contributor.author | Kubáň, Vlastimil | |
dc.contributor.author | Ferreira, Isabel C. F. R. | |
dc.relation.ispartof | Industrial Crops and Products | |
dc.identifier.issn | 0926-6690 Scopus Sources, Sherpa/RoMEO, JCR | |
dc.date.issued | 2017 | |
utb.relation.volume | 95 | |
dc.citation.spage | 365 | |
dc.citation.epage | 373 | |
dc.type | article | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.identifier.doi | 10.1016/j.indcrop.2016.10.046 | |
dc.relation.uri | https://www.sciencedirect.com/science/article/pii/S0926669016307336 | |
dc.subject | Anti-inflammatory | en |
dc.subject | Antimicrobial activity | en |
dc.subject | Antioxidant | en |
dc.subject | Cytotoxicity | en |
dc.subject | Momordica charantia L. | en |
dc.subject | Phenolic compounds | en |
dc.description.abstract | A wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, β-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC50 = 10–0.625 μg/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant. © 2016 Elsevier B.V. | en |
utb.faculty | Faculty of Technology | |
dc.identifier.uri | http://hdl.handle.net/10563/1006914 | |
utb.identifier.obdid | 43877109 | |
utb.identifier.scopus | 2-s2.0-85028017390 | |
utb.identifier.wok | 000390621600042 | |
utb.identifier.coden | ICRDE | |
utb.source | j-scopus | |
dc.date.accessioned | 2017-06-27T08:13:14Z | |
dc.date.available | 2017-06-27T08:13:14Z | |
dc.description.sponsorship | FEDER, Federación Española de Enfermedades Raras | |
dc.description.sponsorship | Foundation for Science and Technology (FCT, Portugal); FEDER [UID/AGR/00690/2013, SFRH/BPD/107855/2015, SFRH/BPD/101413/2014, SFRH/BPD/BPD/68344/2010]; FEDER under LSRE [UID/EQU/50020/2013]; Internal Grant Agency of Tomas Bata University in Zlin [IGA/FT/2016/003] | |
utb.contributor.internalauthor | Svobodová, Blanka | |
utb.contributor.internalauthor | Kubáň, Vlastimil | |
utb.fulltext.affiliation | Blanka Svobodova a,b , Lillian Barros a,c,∗∗ , Ricardo C. Calhelha a , Sandrina Heleno a , Maria Jose Alves d , Simone Walcott e , Miroslava Bittova f , Vlastimil Kuban b , Isabel C.F.R. Ferreira a,∗ a Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Braganc ̧ a, Campus de Santa Apolonia, 1172, 5300-253 Braganc ̧ a, Portugal b Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 275, 762 72 Zlin, Czechia c Laboratory of Separation and Reaction Engineering – Laboratory of Catalysis and Materials (LSRE-LCM), Polytechnic Institute of Braganc ̧ a, Campus de Santa Apolonia, 1134, 5301-857 Braganc ̧ a, Portugal d Escola Superior de Saúde, Instituto Politécnico de Braganc ̧ a, Av. D. Afonso V, 5300-121 Braganc ̧ a, Portugal e Faculty of Science and Technology, University of West Indies, St Augustine Campus, Trinidad and Tobago f Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czechia | |
utb.fulltext.dates | Received 23 June 2016 Received in revised form 19 September 2016 Accepted 26 October 2016 Available online 28 October 2016 | |
utb.fulltext.sponsorship | The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013), LSRE (Project UID/EQU/50020/2013), L. Barros (SFRH/BPD/107855/2015), S. Heleno (SFRH/BPD/101413/2014) and R.C. Calhelha (SFRH/BPD/BPD/68344/2010) grants. This study was financially supported by Internal Grant Agency of Tomas Bata University in Zlin, project Nr. IGA/FT/2016/003. |