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Prognostic influence of internal mammary node drainage in patients with early-stage breast cancer

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dc.title Prognostic influence of internal mammary node drainage in patients with early-stage breast cancer en
dc.contributor.author Lukešová, Lucie
dc.contributor.author Vrána, David
dc.contributor.author Švach, Ivan
dc.contributor.author Zlámalová, Nora
dc.contributor.author Gatěk, Jiří
dc.contributor.author Vlachová, Zuzana
dc.contributor.author Matzenauer, Marcel
dc.contributor.author Koranda, Pavel
dc.contributor.author Hrůzová, Klára
dc.contributor.author Tichý, Tomáš
dc.contributor.author Melichar, Bohuslav
dc.relation.ispartof Anticancer Research
dc.identifier.issn 0250-7005 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 36
utb.relation.issue 12
dc.citation.spage 6641
dc.citation.epage 6646
dc.type article
dc.language.iso en
dc.publisher International Institute of Anticancer Research
dc.identifier.doi 10.21873/anticanres.11272
dc.relation.uri http://ar.iiarjournals.org/content/36/12/6641.abstract
dc.subject Breast cancer en
dc.subject Drainage en
dc.subject Internal mammary nodes en
dc.subject Lymph nodes en
dc.subject Radiotherapy en
dc.description.abstract Background: The management of internal mammary nodes (IMNs) during multidisciplinary treatment of breast cancer has been debated for the last four decades without unequivocal conclusion. Patients and Methods: We retrospectively reviewed patients with breast cancer who underwent sentinel lymph node biopsy at our center from 2008 until 2012. IMN drainage was assessed as a potential risk factor for local and distant disease recurrence. Results: We identified 712 patients, with incidence of drainage to IMNs of 18.4%. No detrimental effect of the pattern of drainage to IMNs was found after a median follow-up of 58 months. A similar outcome was observed when drainage to IMNs was evaluated as a risk factor for patient survival. The potential risk factors for drainage to IMNs during sentinel lymph node biopsy were younger age (p=0.002) and tumor location in lower-outer, lower-inner, and upper-inner versus upper-outer quadrant (p<0.0001). Conclusion: The drainage to IMNs is unlikely to have a detrimental effect on patient outcome. en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1006807
utb.identifier.obdid 43875404
utb.identifier.scopus 2-s2.0-85002388925
utb.identifier.wok 000390946700058
utb.identifier.coden ANTRD
utb.source j-scopus
dc.date.accessioned 2017-02-28T15:11:28Z
dc.date.available 2017-02-28T15:11:28Z
dc.description.sponsorship [LO1304]
utb.contributor.internalauthor Gatěk, Jiří
utb.fulltext.affiliation LUCIE LUKESOVA 1, DAVID VRANA 1,2,3, IVAN SVACH 4, NORA ZLAMALOVA 4, JIRI GATEK 5,8, ZUZANA VLACHOVÁ 1, MARCEL MATZENAUER 1, PAVEL KORANDA 6, KLARA HRUZOVA 1, TOMAS TICHY 7, BOHUSLAV MELICHAR 1,2 Departments of 1 Oncology, 4 Surgery I, 6 Nuclear Medicine, 7 Department of Clinical and Molecular Pathology and 2 Institute of Molecular and Translational Medicine Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; 3 Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic; 5 Department of Surgery, Atlas Hospital, Zlín, Czech Republic; 8 Faculty of Humanities, Tomas Bata University in Zlín, Zlin Czech Republic Correspondence to: Dr. David Vrána, Ph.D., Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic. Tel: +420 588444295, Fax: +420 588444295, e-mail: davvrana@gmail.com
utb.fulltext.dates Received October 28, 2016 Revised November 14, 2016 Accepted November 15, 2016
utb.fulltext.faculty Faculty of Humanities
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