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Blood coagulation and platelet adhesion on polyaniline films

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dc.title Blood coagulation and platelet adhesion on polyaniline films en
dc.contributor.author Humpolíček, Petr
dc.contributor.author Kuceková, Zdenka
dc.contributor.author Kašpárková, Věra
dc.contributor.author Pelková, Jana
dc.contributor.author Modic, Martina
dc.contributor.author Junkar, Ita
dc.contributor.author Trchová, Miroslava
dc.contributor.author Bober, Patrycja
dc.contributor.author Stejskal, Jaroslav
dc.contributor.author Lehocký, Marián
dc.relation.ispartof Colloids and Surfaces B: Biointerfaces
dc.identifier.issn 0927-7765 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2015
utb.relation.volume 133
dc.citation.spage 278
dc.citation.epage 285
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.colsurfb.2015.06.008
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S092777651500380X
dc.subject Blood coagulation en
dc.subject Hemocompatibility en
dc.subject Platelet adhesion en
dc.subject Poly(2-acrylamido-2-methyl-1-propanesulfonic acid) en
dc.subject Polyaniline en
dc.description.abstract Polyaniline is a promising conducting polymer with still increasing application potential in biomedicine. Its surface modification can be an efficient way how to introduce desired functional groups and to control its properties while keeping the bulk characteristics of the material unchanged. The purpose of the study was to synthetize thin films of pristine conducting polyaniline hydrochloride, non-conducting polyaniline base and polyaniline modified with poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPSA) and investigate chosen parameters of their hemocompatibility. The modification was performed either by introduction of PAMPSA during the synthesis or by reprotonation of polyaniline base. The polyaniline hydrochloride and polyaniline base had no impact on blood coagulation and platelet adhesion. By contrast, the polyaniline reprotonated with PAMPSA completely hindered coagulation thanks to its interaction with coagulation factors Xa, Va and IIa. The significantly lower platelets adhesion was also found on this surface. Moreover, this film maintains its conductivity at pH of 6, which is an improvement in comparison with standard polyaniline hydrochloride losing most of its conductivity at pH of 4. Polyaniline film with PAMPSA introduced during synthesis had an impact on platelet adhesion but not on coagulation. The combined conductivity, anticoagulation activity, low platelet adhesion and improved conductivity at pH closer to physiological, open up new possibilities for application of polyaniline reprotonated by PAMPSA in blood-contacting devices, such as catheters or blood vessel grafts. © 2015 Elsevier B.V.. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1005229
utb.identifier.rivid RIV/70883521:28610/15:43873024!RIV16-MSM-28610___
utb.identifier.obdid 43873444
utb.identifier.scopus 2-s2.0-84935027104
utb.identifier.wok 000359172600034
utb.identifier.pubmed 26119372
utb.identifier.coden CSBBE
utb.source j-wok
dc.date.accessioned 2015-08-14T09:25:58Z
dc.date.available 2015-08-14T09:25:58Z
dc.description.sponsorship Czech Science Foundation [13-08944S]; Ministry of Education, Youth and Sport of the Czech Republic [CZ.1.05/2.1.00/03.0111]; TBU in Zlin [IGA/FT/2014/004]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Kuceková, Zdenka
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Pelková, Jana
utb.contributor.internalauthor Lehocký, Marián
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Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International