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The influence of quarternary salt on hyaluronan conformation and particle size in solution

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dc.title The influence of quarternary salt on hyaluronan conformation and particle size in solution en
dc.contributor.author Gřundělová, Lenka
dc.contributor.author Mráček, Aleš
dc.contributor.author Kašpárková, Věra
dc.contributor.author Minařík, Antonín
dc.contributor.author Smolka, Petr
dc.relation.ispartof Carbohydrate Polymers
dc.identifier.issn 0144-8617 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2013
utb.relation.volume 98
utb.relation.issue 1
dc.citation.spage 1039
dc.citation.epage 1044
dc.type article
dc.language.iso en
dc.publisher Pergamon en
dc.identifier.doi 10.1016/j.carbpol.2013.06.057
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S014486171300653X
dc.subject Critical micellar concentration en
dc.subject Dynamic light scattering en
dc.subject Hyaluronan en
dc.subject Hyaluronan conformation en
dc.subject Hyaluronan hydrophobic interactions en
dc.subject Quarternary salts en
dc.description.abstract Interaction of hyaluronan (NaHy) with the quaternary salt, benzalkonium chloride (BAC), was studied. Based on the DLS experiments, viscometry and surface tension measurements executed on hyaluronan samples with two molecular weights of Mw = 1.8 MDa and Mw = 0.35 MDa, the hypothesis was proposed suggesting that at certain BAC concentrations, hyaluronan can form aggregates, which lead to increase of the polymer coil size measured as z-average diameter. Moreover, it was confirmed that within the whole range of BAC concentrations, repeated variations in size and conformations of polymer coils occur, being connected with the critical micellar concentration of BAC and with hydrophobic interactions of nonpolar segments of BAC with hyaluronan hydrophobic domains. Tensiometry, DLS and viscometry data support the assumption that variations of thermodynamical "favourability" of BAC-BAC or NaHy-BAC interactions take place in hyaluronan solutions, based on the BAC concentration. © 2013 Elsevier Ltd. All rights reserved. en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1003505
utb.identifier.obdid 43869857
utb.identifier.scopus 2-s2.0-84885171092
utb.identifier.wok 000325835600136
utb.identifier.coden CAPOD
utb.source j-scopus
dc.date.accessioned 2013-10-22T08:34:52Z
dc.date.available 2013-10-22T08:34:52Z
utb.contributor.internalauthor Gřundělová, Lenka
utb.contributor.internalauthor Mráček, Aleš
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Minařík, Antonín
utb.contributor.internalauthor Smolka, Petr
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