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On the development and characterisation of crosslinked sodium alginate/gelatine hydrogels

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dc.title On the development and characterisation of crosslinked sodium alginate/gelatine hydrogels en
dc.contributor.author Saarai, Amarjargal
dc.contributor.author Kašpárková, Věra
dc.contributor.author Sedláček, Tomáš
dc.contributor.author Sáha, Petr
dc.relation.ispartof Journal of the Mechanical Behavior of Biomedical Materials
dc.identifier.issn 1751-6161 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2013
utb.relation.volume 18
dc.citation.spage 152
dc.citation.epage 166
dc.type article
dc.language.iso en
dc.publisher Elsevier en
dc.identifier.doi 10.1016/j.jmbbm.2012.11.010
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1751616112003220
dc.subject Crosslinking en
dc.subject Hydrogel en
dc.subject Sodium alginate/gelatine en
dc.subject Swelling behaviour en
dc.subject Viscoelastic properties en
dc.description.abstract Sodium alginate (SA) and gelatine (G) based hydrogels with various SA/G ratios, crosslinked with calcium ions (Ca2+) and glutaraldehyde (GTA), respectively, were developed. Scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR), and dynamic mechanical analysis (DMA) were applied to determine their physicochemical characterization. The swelling studies, conducted in phosphate-buffered saline with a pH ranging from 1 to 11 at 37°C, were utilized for an evaluation of their absorption ability. FTIR spectra of the Ca2+ crosslinked SA/G hydrogels revealed a small shift in symmetric stretching carboxyl groups, indicating an ionic binding between the Ca2+ ions and the SA. Increasing the G content in hydrogels crosslinked with GTA significantly changed the shapes of the amide I and II bands in the FTIR spectra, thus confirming the G-GTA crosslink formation. After crosslinking, a DMA study proved the enhanced viscoelastic properties and improved thermal stability of the prepared samples. The obtained data indicated that Ca2+ crosslinked hydrogels with a SA/G 50/50 ratio provide a good balance of swelling and viscoelastic properties, making them applicable as a potential nontoxic wound dressing material capable of adequately assuring a moist environment, elasticity and mechanical strength for comfortable wound healing. © 2012 Elsevier Ltd. en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1003080
utb.identifier.obdid 43869891
utb.identifier.scopus 2-s2.0-84871815719
utb.identifier.wok 000316585400016
utb.source j-scopus
dc.date.accessioned 2013-01-17T00:00:54Z
dc.date.available 2013-01-17T00:00:54Z
utb.contributor.internalauthor Saarai, Amarjargal
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Sedláček, Tomáš
utb.contributor.internalauthor Sáha, Petr
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