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Biocompatibility of polyaniline

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dc.title Biocompatibility of polyaniline en
dc.contributor.author Humpolíček, Petr
dc.contributor.author Kašpárková, Věra
dc.contributor.author Sáha, Petr
dc.contributor.author Stejskal, Jaroslav
dc.relation.ispartof Synthetic Metals
dc.identifier.issn 0379-6779 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2012
utb.relation.volume 162
utb.relation.issue 7-8
dc.citation.spage 722
dc.citation.epage 727
dc.type article
dc.language.iso en
dc.publisher Elsevier S.A. en
dc.identifier.doi 10.1016/j.synthmet.2012.02.024
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0379677912000781
dc.subject Biocompatibility en
dc.subject Conducting polymer en
dc.subject Cytotoxicity en
dc.subject Polyaniline en
dc.subject Skin irritation en
dc.description.abstract Both the non-conducting polyaniline, emeraldine base, and its conducting form, polyaniline hydrochloride, were tested for their biocompatibility in terms of skin irritation, sensitization and cytotoxicity performed on human immortalized non-tumorigenic keratinocyte and human hepatocellular carcinoma cell lines. The testing was carried out on extracts of polyaniline powders in agreement with requirements of international standards applicable for testing of medical devices. The results can be hence generally employed in all types of materials and devices containing polyaniline in various concentrations. The study confirmed that polyaniline has not induced any sensitization and skin irritation either. In contrast, both polyaniline forms showed considerable cytotoxicity, which was higher for polyaniline hydrochloride compared to polyaniline base and was observed on both cell lines. Differences between cytotoxicity found on human immortalized non-tumorigenic keratinocyte cell line and human hepatocellular carcinoma cell line were attributed to variability in specific metabolic capabilities of the respective cell lines. Significant reduction of cytotoxicity was achieved through deprotonation and reprotonation procedure, used as an additional purification step after polymer synthesis. Accordingly, the cytotoxicity is thus caused rather by the reaction by-products and residues than by polyaniline itself. © 2012 Elsevier B.V. All rights reserved. en
utb.faculty Faculty of Technology
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1002779
utb.identifier.rivid RIV/70883521:28110/12:43867814!RIV13-MSM-28110___
utb.identifier.rivid RIV/70883521:28610/12:43867814!RIV13-MSM-28610___
utb.identifier.obdid 43867902
utb.identifier.scopus 2-s2.0-84858979155
utb.identifier.wok 000303976500026
utb.identifier.coden SYMED
utb.source j-scopus
dc.date.accessioned 2012-06-04T11:33:52Z
dc.date.available 2012-06-04T11:33:52Z
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Sáha, Petr
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