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Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: Effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity

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dc.title Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: Effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity en
dc.contributor.author Merchan, Martha
dc.contributor.author Sedlaříková, Jana
dc.contributor.author Friedrich, Miha
dc.contributor.author Sedlařík, Vladimír
dc.contributor.author Sáha, Petr
dc.relation.ispartof Polymer Bulletin
dc.identifier.issn 0170-0839 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2011
utb.relation.volume 67
utb.relation.issue 6
dc.citation.spage 997
dc.citation.epage 1016
dc.type article
dc.language.iso en
dc.publisher Springer en
dc.identifier.doi 10.1007/s00289-011-0474-3
dc.relation.uri http://www.springerlink.com/content/e11v153244011684/
dc.subject antibacterial modifications en
dc.subject antibiotics en
dc.subject mechanical properties en
dc.subject polyvinyl chloride en
dc.subject release activity en
dc.subject thermal stability en
dc.subject thermoplastic compounding en
dc.description.abstract Novel polymeric systems with antibacterial properties based on medical-grade polyvinyl chloride and antibiotics (Ampicillin, Minocycline, and Rifampicin) in the concentrations up to 1 wt% were prepared by thermoplastic compounding. Thermal stability of the antibiotics was corroborated by IR spectroscopy, X-ray diffraction, differential scanning calorimetry, and 1H nuclear magnetic resonance spectroscopy. The effect of chemical structure on mechanical properties of the prepared systems was determined by tensile testing measurements and correlated with optical microscopy observations. In vitro antibacterial properties of samples were determined by agar diffusion and adhesion test against Gramnegative and Gram-positive bacteria. Antibiotic release experiments in distilled water and physiological saline solution and follow-up detecting by Ultraviolet-Visible spectroscopy were carried out. A mathematical model was applied to evaluate the release kinetics of the antibiotics from prepared polymeric systems. © Springer-Verlag 2010. en
utb.faculty Faculty of Technology
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1002655
utb.identifier.rivid RIV/70883521:28110/11:43865600!RIV12-MPO-28110___
utb.identifier.rivid RIV/70883521:28610/11:43865600!RIV12-MPO-28610___
utb.identifier.obdid 43865614
utb.identifier.scopus 2-s2.0-80053956729
utb.identifier.wok 000294201900006
utb.identifier.coden POBUD
utb.source j-scopus
dc.date.accessioned 2012-02-10T13:15:24Z
dc.date.available 2012-02-10T13:15:24Z
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Merchan, Martha
utb.contributor.internalauthor Sedlaříková, Jana
utb.contributor.internalauthor Sedlařík, Vladimír
utb.contributor.internalauthor Sáha, Petr
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