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Permeability and biocompatibility of Novel hydrogel wound dressings

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dc.title Permeability and biocompatibility of Novel hydrogel wound dressings en
dc.contributor.author Roy, Niladri
dc.contributor.author Saha, Nabanita
dc.contributor.author Humpolíček, Petr
dc.contributor.author Sáha, Petr
dc.relation.ispartof Soft Materials
dc.identifier.issn 1539-445X Scopus Sources, Sherpa/RoMEO, JCR
dc.identifier.issn 1539-4468 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2010
utb.relation.volume 8
utb.relation.issue 4
dc.citation.spage 338
dc.citation.epage 357
dc.type article
dc.language.iso en
dc.publisher Royal Society of Chemistry (RSC) en
dc.identifier.doi 10.1080/1539445X.2010.502955
dc.relation.uri http://www.informaworld.com/smpp/content~db=all?content=10.1080/1539445X.2010.502955
dc.subject biokompatibilita cs
dc.subject cytotoxicita cs
dc.subject hydrogel cs
dc.subject podráždění kůže cs
dc.subject krytí ran cs
dc.subject Biocompatibility en
dc.subject cytotoxicity en
dc.subject hydrogel en
dc.subject skin irritation en
dc.subject wound dressing en
dc.description.abstract Hydrogely pro krytí ran jsou popularizovány pro jejich přispěvek k hojivým účinkům. Byly přiopraveny hydrogely z polyvinylpyrrolidonu (PVP), karboxymetylcelulozy (CMC) a kyseliny borité (BA). Byla testována permeabilita pro vodní páru, mikrobiální penetrace a biokompatibilita. Výsledky ukazují ze připravené hydrogely mají vysoký potenciál pro použití v hojení popálenin a dalších ran. cs
dc.description.abstract Hydrogel dressings are being popularized for wound care management because of their softness, tissue compatibility, and ability to enhance wound healing process. PVP-CMC and PVP-CMC-BA hydrogels were prepared using polyvinylpyrrolidone (PVP), sodium-carboxymethylcellulose (CMC), polyethyleneglycol (PEG), agar, glycerine and without/with boric acid (BA). Permeability: water vapor transmission and microbe penetration and biocompatibility: cytotoxicity, skin irritation, and skin sensitization tests of hydrogels were performed. Water vapor transmission ability of hydrogels shows positive response to gas permeability, whereas microbe penetration ability by Staphylococcus aureus and Escherichia coli shows negative penetrability en
dc.description.abstract thus these two hydrogel dressings could be considered as a good barrier against microbes having an excellent oxygen diffusion property. In vitro assay of cytotoxicity was carried out in presence of human immortalized non-tumorigenic keratinocyte cell line (HaCaT), which was further confirmed with balb/c 3T3 mouse fibroblasts cells. The skin irritation test was evaluated on albino rabbits and sensitization test was carried out on albino guinea-pigs under in vivo state. Both PVP-CMC and PVP-CMC-BA represented mostly negative effect on cytotoxicity, dermal irritation, and/or sensitization. All the results indicate that both PVP-CMC and PVP-CMC-BA hydrogels have great potential for biomedical applications, especially for burn skin treatment as well as wound dressings materials. en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1001206
utb.identifier.rivid RIV/70883521:28110/10:63509500!RIV11-MSM-28110___
utb.identifier.obdid 43864563
utb.identifier.scopus 2-s2.0-78649496435
utb.identifier.wok 000284417300003
utb.source j-riv
dc.rights.access openAccess
utb.contributor.internalauthor Roy, Niladri
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Sáha, Petr
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