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Vitamin D supplementation in inflammatory bowel disease: the role of dosage and patient compliance

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dc.title Vitamin D supplementation in inflammatory bowel disease: the role of dosage and patient compliance en
dc.contributor.author Kojecký, Vladimír
dc.contributor.author Adamíková, Alena
dc.contributor.author Klímek, Petr
dc.relation.ispartof Bratislava Medical Journal-Bratislavske Lekarske Listy
dc.identifier.issn 0006-9248 OCLC, Ulrich, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 117
utb.relation.issue 3
dc.citation.spage 148
dc.citation.epage 151
dc.type article
dc.language.iso en
dc.publisher Comenius Univ
dc.identifier.doi 10.4149/BLL_2016_028
dc.subject inflammatory bowel disease en
dc.subject vitamin D en
dc.subject supplementation en
dc.subject Crohn's disease en
dc.description.abstract OBJECTIVES: Vitamin D substitution is recommended in patients with inflammatory bowel disease. Specific guidelines are lacking. The aim of this study was to assess the effect of vitamin D supplementation with respect to dosage and patient compliance. METHODS: A prospective cohort study of 167 Crohn disease/ulcerative colitis outpatients. Patients were screened for serum vitamin D (250HD(2+3)) at the end of summer and in late winter. Demographic data, history of vitamin D supplementation were recorded and matched with prescription records. RESULTS: A total of 57 subjects used vitamin D supplementation (mean dose 1104 IU/day). 250HD(2+3) levels were lower (p < 0.001) in winter both in substituted and unsubstituted group, without any differences between groups within the same season. 250HD(2+3) levels did not correlate with the substitution dose. 52.1 % of subjects were fully compliant with substitution. 250HD(2+3) and prevalence of vitamin D deficit in this group were comparable with unsubstituted subjects except a higher prevalence of vitamin D insufficiency (p < 0.02). CONCLUSION: Fixed dosage of 1100 IU/day of vitamin D was insufficient to correct the deficiency. Patient compliance with vitamin D supplementation was low, however this fact did not significantly contribute to the degree of vitamin D deficiency in this dosage (Tab. 3, Fig. 1, Ref. 21). Text in PDF www.elis.sk. en
utb.faculty Faculty of Management and Economics
dc.identifier.uri http://hdl.handle.net/10563/1006348
utb.identifier.obdid 43875087
utb.identifier.scopus 2-s2.0-85014966556
utb.identifier.wok 000371851500005
utb.identifier.pubmed 26925744
utb.source j-wok
dc.date.accessioned 2016-06-22T12:14:50Z
dc.date.available 2016-06-22T12:14:50Z
utb.contributor.internalauthor Klímek, Petr
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