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Hazards of secondary bromadiolone intoxications evaluated using high-performance liquid chromatography with electrochemical detection

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dc.title Hazards of secondary bromadiolone intoxications evaluated using high-performance liquid chromatography with electrochemical detection en
dc.contributor.author Křížková, Soňa
dc.contributor.author Beklová, Miroslava
dc.contributor.author Pikula, Jiří
dc.contributor.author Adam, Vojtěch
dc.contributor.author Horna, Aleš
dc.contributor.author Kizek, René
dc.relation.ispartof Sensors
dc.identifier.issn 1424-8220 OCLC, Ulrich, Sherpa/RoMEO, JCR
dc.date.issued 2007-07
utb.relation.volume 7
utb.relation.issue 7
dc.citation.spage 1271
dc.citation.epage 1286
dc.type article
dc.language.iso en
dc.publisher Molecular Diversity Preservation International (MDPI) en
dc.identifier.doi 10.3390/s7071271
dc.relation.uri http://www.mdpi.com/1424-8220/7/7/1271/
dc.subject anticoagulant rodenticide en
dc.subject electrochemistry en
dc.subject cyclic voltammetry en
dc.subject animal tissues en
dc.subject non-target organisms en
dc.subject Eisenia fetida en
dc.subject Microtus arvalis en
dc.subject Lepus europaeus en
dc.description.abstract This study reported on the possibility of intoxications of non-target wild animals associated with use of bromadiolone as the active component of rodenticides with anticoagulation effects. A laboratory test was done with earthworms were exposed to bromadiolone-containing granules under the conditions specified in the modified OECD 207 guideline. No mortality of earthworms was observed during the fourteen days long exposure. When the earthworms from the above test became a part of the diet of common voles in the following experiment, no mortality of consumers was observed too. However, electrochemical analysis revealed higher levels of bromadiolone in tissues from earthworms as well as common voles compared to control animals. There were determined comparable levels of bromadiolone in the liver tissue of common voles after primary (2.34 +/- 0.10 mu g/g) and secondary (2.20 +/- 0.53 mu g/g) intoxication. Therefore, the risk of secondary intoxication of small mammalian species feeding on bromadiolone-containing earthworms is the same as of primary intoxication through baited granules. Bromadiolone bio- accumulation in the food chain was monitored using the newly developed analytical procedure based on the use of a liquid chromatography coupled with electrochemical detector (HPLC-ED). The HPLC-ED method allowed to determine the levels of bromadiolone in biological samples and is therefore suitable for examining the environmental hazards of this substance. en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1002108
utb.identifier.obdid 43865396
utb.identifier.scopus 2-s2.0-34547640651
utb.identifier.wok 000248319500015
utb.source j-wok
dc.date.accessioned 2011-08-16T15:06:30Z
dc.date.available 2011-08-16T15:06:30Z
dc.rights Attribution 3.0 International
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.rights.access openAccess
utb.contributor.internalauthor Horna, Aleš
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