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Electrochemical sensors for detection of acetylsalicylic acid

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dc.title Electrochemical sensors for detection of acetylsalicylic acid en
dc.contributor.author Šupálková, Veronika
dc.contributor.author Petřek, Jiří
dc.contributor.author Havel, Ladislav
dc.contributor.author Křížková, Soňa
dc.contributor.author Petrlová, Jitka
dc.contributor.author Adam, Vojtěch
dc.contributor.author Potěšil, David
dc.contributor.author Babula, Petr
dc.contributor.author Beklová, Miroslava
dc.contributor.author Horna, Aleš
dc.contributor.author Kizek, René
dc.relation.ispartof Sensors
dc.identifier.issn 1424-8220 OCLC, Ulrich, Sherpa/RoMEO, JCR
dc.date.issued 2006-11
utb.relation.volume 6
utb.relation.issue 11
dc.citation.spage 1483
dc.citation.epage 1497
dc.type article
dc.language.iso en
dc.publisher Molecular Diversity Preservation International (MDPI) en
dc.identifier.doi 10.3390/s6111483
dc.relation.uri http://www.mdpi.com/1424-8220/6/11/1483/
dc.subject sensor en
dc.subject acetylsalicylic acid (aspirin) en
dc.subject salicylic acid en
dc.subject thiosalicylic acid en
dc.subject 3,5-dinitrosalicylic acid en
dc.subject 5-sulfosalicylic acid en
dc.subject pharmaceutical drug en
dc.subject square wave voltammetry en
dc.subject carbon electrodes en
dc.subject flow injection analysis with electrochemical detection en
dc.description.abstract Acetylsalicylic acid ( AcSA), or aspirin, was introduced in the late 1890s and has been used to treat a variety of inflammatory conditions. The aim of this work was to suggest electrochemical sensor for acetylsalicylic detection. Primarily, we utilized square wave voltammetry ( SWV) using both carbon paste electrode ( CPE) and of graphite pencil electrode ( GPE) as working ones to indirect determination of AcSA. The principle of indirect determination of AcSA bases in its hydrolysis on salicylic acid ( SA), which is consequently detected. Thus, we optimized both determination of SA and conditions for AcSA hydrolysis and found out that the most suitable frequency, amplitude, step potential and the composition and pH of the supporting electrolyte for the determination of SA was 260 Hz, 50 mV, 10 mV and Britton-Robinson buffer ( pH 1.81), respectively. The detection limit ( S/N = 3) of the SA was 1.3 ng/ml. After that, we aimed on indirect determination of AcSA by SWV CPE. We tested the influence of pH of Britton-Robinson buffer and temperature on yield of hydrolysis, and found out that 100% hydrolysis of AcSA was reached after 80 minutes at pH 1.81 and 90 C. The method for indirect determination of AcSA has been utilized to analyse pharmaceutical drug. The determined amount of AcSA in the pharmaceutical drug was in good agreement with the declared amounts. Moreover, we used GPE for determination of AcSA in a pharmaceutical drug. Base of the results obtained from stationary electrochemical instrument we used flow injection analysis with electrochemical detection to determine of salicylates ( SA, AcSA, thiosalicylic acid, 3,5-dinitrosalicylic acid and 5-sulfosalicylic acid - SuSA). We found out that we are able to determine all of detected salicylates directly without any pre-treatment, hydrolysis and so on at units of femtomoles per injection ( 5 mu l). en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1002093
utb.identifier.obdid 43865412
utb.identifier.scopus 2-s2.0-33947402312
utb.identifier.wok 000244633800004
utb.source j-wok
dc.date.accessioned 2011-08-16T15:06:28Z
dc.date.available 2011-08-16T15:06:28Z
dc.rights Attribution 3.0 International
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.rights.access openAccess
utb.contributor.internalauthor Horna, Aleš
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