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Graphene oxide produced from spent coffee grounds in electrospun cellulose acetate scaffolds for tissue engineering applications

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dc.title Graphene oxide produced from spent coffee grounds in electrospun cellulose acetate scaffolds for tissue engineering applications en
dc.contributor.author Challa, Adam Aberra
dc.contributor.author Saha, Nabanita
dc.contributor.author Szewczyk, Piotr Krzysztof
dc.contributor.author Karbowniczek, Joanna E.
dc.contributor.author Stachewicz, Urszula
dc.contributor.author Asabuwa Ngwabebhoh, Fahanwi
dc.contributor.author Sáha, Petr
dc.relation.ispartof Materials Today Communications
dc.identifier.issn 2352-4928 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2023
utb.relation.volume 35
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.mtcomm.2023.105974
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S2352492823006657
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S2352492823006657/pdfft?md5=829542998cd4b8cbb8cd53bf2932bee4&pid=1-s2.0-S2352492823006657-main.pdf
dc.subject nanofibrous scaffolds en
dc.subject graphene oxide en
dc.subject biomass en
dc.subject electrospinning en
dc.subject tissue engineering en
dc.description.abstract Biomaterials are widely used in the field of tissue engineering as coatings, scaffolds, or injectables. Since these materials need to be compatible with the biological conditions of the human body, improving the sources and methods of production for biomaterials call for continuous innovation. In this study, fibers were electrospun from cellulose acetate (CA) polymer solution using graphene oxide (GO) as a filler, for bone tissue engineering applications. The GO was synthesized from spent coffee grounds, a carbonaceous source that is discarded abundantly. A non-energy-intensive methodology was used for the production. CA with 5 wt% of GO nanoparticles was dissolved in a dimethylacetamide and acetone solvent mixture to produce the polymer solution. The nanofibrous scaffolds were tested for their morphological and mechanical properties as well as their biocompatibility. Scanning electron microscopy (SEM) results showed that electrospinning produced smooth nanofibers with very few beads. Fiber diameters decreased with the addition of GO nanoparticles. Mechanical testing showed that modified CA scaffolds exhibited an improved tensile strength of 115.75 kPa on average compared to the pristine ones. In addition, a cell culture study revealed that using graphene oxide as a modifier of the matrix is non-toxic and promoted cell growth. The oxygen-rich and hydrophilic nature of GO played a role in the biocompatibility of the produced fibers. In general, this study showed that agro-residual biomass can be used to produce and modify biomaterials. This aspect contributes to research on sustainable bio-composites and the effort in environmental conservation. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1011513
utb.identifier.obdid 43884791
utb.identifier.scopus 2-s2.0-85152899831
utb.identifier.wok 001042295600001
utb.source j-scopus
dc.date.accessioned 2023-05-24T13:10:15Z
dc.date.available 2023-05-24T13:10:15Z
dc.description.sponsorship IGA/CPS/2022/006, RP/CPS/2022/005; Tomas Bata University in Zlin, TBU; European Cooperation in Science and Technology, COST: CA-17107; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT: MSMT-44726/2013; Narodowe Centrum Nauki, NCN: 2019/33/B/ST5/01311
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Challa, Adam Aberra
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Asabuwa Ngwabebhoh, Fahanwi
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.sponsorship This work is supported by the Ministry of Education, Youth and Sports of the Czech Republic – DKRVO (RP/CPS/2022/005) and the Internal Grant Agency (IGA) project IGA/CPS/2022/006 of the Center of Polymer Systems at the Tomas Bata University in Zlin, Czech Republic. The first author is pleased to acknowledge the Ministry of Education, Youth and Sports support of foreign nationals under the reference number MSMT-44726/2013 as well as COST Action CONTEXT (CA-17107) for the grant of short-term scientific mission to work at AGH University of Science and Technology in Krakow, Poland. U.S. thanks the funding used from the OPUS 17 project grant provided by the National Science Centre in Poland, No. 2019/33/B/ST5/01311 allowing electrospinning and cell culture studies.
utb.wos.affiliation [Challa, Adam Aberra; Saha, Nabanita; Ngwabebhoh, Fahanwi Asabuwa; Saha, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin, Czech Republic; [Szewczyk, Piotr K.; Karbowniczek, Joanna E.; Stachewicz, Urszula] AGH Univ Sci & Technol, Fac Met Engn & Ind Comp Sci, Krakow, Poland
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Czech Republic; Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Kraków, Poland
utb.fulltext.projects DKRVO RP/CPS/2022/005
utb.fulltext.projects IGA/CPS/2022/006
utb.fulltext.projects MSMT-44726/2013
utb.fulltext.projects CA-17107
utb.fulltext.projects 2019/33/B/ST5/01311
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