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In situ observation of hyaluronan molecular weight effectiveness within articular cartilage lubrication

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dc.title In situ observation of hyaluronan molecular weight effectiveness within articular cartilage lubrication en
dc.contributor.author Rebenda, David
dc.contributor.author Ranuša, Matúš
dc.contributor.author Čípek, Pavel
dc.contributor.author Toropitsyn, Evgeniy
dc.contributor.author Vrbka, Martin
dc.relation.ispartof Lubricants
dc.identifier.issn 2075-4442 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2023
utb.relation.volume 11
utb.relation.issue 1
dc.type article
dc.language.iso en
dc.publisher MDPI
dc.identifier.doi 10.3390/lubricants11010012
dc.relation.uri https://www.mdpi.com/2075-4442/11/1/12
dc.subject articular cartilage en
dc.subject friction en
dc.subject hyaluronic acid en
dc.subject lubrication en
dc.subject viscosupplementation en
dc.description.abstract Degradation of the articular cartilage (AC) structure due to osteoarthritis significantly influences its friction and lubrication mechanisms. Injection with exogenous hyaluronic acid (HA) is one of the ways to slow down the progress of these changes. The present paper aims to determine the effect of HA on the friction and lubrication processes of the synovial joint model. The main emphasis is placed on the effect of HA molecular weight (MW) on the coefficient of friction (COF) and the interactions between HA and other constituents of synovial fluid (SF). Frictional measurements between the AC surface and the glass were performed with simultaneous in situ observation of the contact zone by fluorescence microscopy. Using this methodology, a decrease in AC COF with an increase in the fluorescence intensity emitted from contact with HA was observed, while the phenomenon was found to be MW-dependent. These findings demonstrate that high-MW HA is more effective within a resumption of healthy AC lubrication due to a better adhesion to the AC surface. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1011382
utb.identifier.obdid 43884748
utb.identifier.scopus 2-s2.0-85146757532
utb.identifier.wok 000915175500001
utb.source j-scopus
dc.date.accessioned 2023-02-17T00:08:31Z
dc.date.available 2023-02-17T00:08:31Z
dc.description.sponsorship Grantová Agentura České Republiky, GA ČR
dc.description.sponsorship Czech Science Foundation [20-00483S]
dc.rights Attribution 4.0 International
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Footwear Research Centre
utb.contributor.internalauthor Rebenda, David
utb.fulltext.sponsorship This research was carried out under the project “An Investigation of Synovial Fluid Viscosupplementation and its Impact on Friction and Lubrication” (grant number 20-00483S) with financial support from the Czech Science Foundation.
utb.wos.affiliation [Rebenda, David; Ranusa, Matus; Cipek, Pavel; Vrbka, Martin] Brno Univ Technol, Fac Mech Engn, Techn 2896-2, Brno 61669, Czech Republic; [Rebenda, David] Tomas Bata Univ Zlin, Univ Inst, Footwear Res Ctr, Ovcirnou 43685, Zlin 76001, Czech Republic; [Toropitsyn, Evgeniy] Contipro As, Dolni Dobrouc 401, Dolni Dobrouc 56102, Czech Republic; [Toropitsyn, Evgeniy] Charles Univ Prague, Fac Med 1, Biocev, Prumyslova 595, Vestec 25250, Czech Republic
utb.scopus.affiliation Faculty of Mechanical Engineering, Brno University of Technology, Brno, 2896/2, Technická, 616 69, Czech Republic; Footwear Research Centre, University Institute, Tomas Bata University in Zlin, Nad Ovčírnou IV 3685, Zlín, 760 01, Czech Republic; Contipro a.s, Dolní Dobrouč 401, Dolní Dobrouč, 561 02, Czech Republic; First Faculty of Medicine, Charles University, Průmyslová 595, Vestec, Biocev, 252 50, Czech Republic
utb.fulltext.projects 20-00483S
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Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International