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Composite scaffolds based on bacterial cellulose for wound dressing application

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dc.title Composite scaffolds based on bacterial cellulose for wound dressing application en
dc.contributor.author Das, Munmi
dc.contributor.author Zandraa, Oyunchimeg
dc.contributor.author Mudenur, Chethana
dc.contributor.author Saha, Nabanita
dc.contributor.author Sáha, Petr
dc.contributor.author Mandal, Bishnupada
dc.contributor.author Katiyar, Vimal
dc.relation.ispartof ACS Applied Bio Materials
dc.identifier.issn 2576-6422 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2022
utb.relation.volume 5
utb.relation.issue 8
dc.citation.spage 3722
dc.citation.epage 3733
dc.type article
dc.language.iso en
dc.publisher American Chemical Society
dc.identifier.doi 10.1021/acsabm.2c00226
dc.relation.uri https://pubs.acs.org/doi/10.1021/acsabm.2c00226
dc.subject bacterial cellulose en
dc.subject polycaprolactone en
dc.subject gentamicin en
dc.subject streptomycin en
dc.subject antimicrobial properties en
dc.subject biocompatibility en
dc.subject wound dressing en
dc.description.abstract Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity. However, the lack of antibacterial activity slightly restricts its application as a wound dressing material. In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing. Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images. X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%). In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications. Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites. The prepared scaffolds also exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus. The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications. © 2022 American Chemical Society. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1011081
utb.identifier.obdid 43884281
utb.identifier.scopus 2-s2.0-85136342228
utb.identifier.wok 000831727300001
utb.identifier.pubmed 35853242
utb.source J-wok
dc.date.accessioned 2022-08-17T13:17:24Z
dc.date.available 2022-08-17T13:17:24Z
dc.description.sponsorship Tomas Bata University in Zlin, TBU
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Zandraa, Oyunchimeg
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.affiliation Munmi Das, Oyunchimeg Zandraa, Chethana Mudenur, Nabanita Saha, Petr Sáha, Bishnupada Mandal, and Vimal Katiyar* Corresponding Author • Vimal Katiyar − Department of Chemical Engineering, Indian Institute of Technology, Guwahati, Assam 781039, India; Authors • Munmi Das − Department of Chemical Engineering, Indian Institute of Technology, Guwahati, Assam 781039, India • Oyunchimeg Zandraa − Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic • Chethana Mudenur − Department of Chemical Engineering, Indian Institute of Technology, Guwahati, Assam 781039,India • Nabanita Saha − Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic • Petr Sáha − Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic • Bishnupada Mandal − Department of Chemical Engineering, Indian Institute of Technology, Guwahati, Assam 781039, India
utb.fulltext.dates Received: March 14, 2022 Accepted: July 9, 2022 Published: July 19, 2022
utb.fulltext.sponsorship This work was carried with the help of research facilities available at Department of Chemical Engineering and Centre for Sustainable Polymers, situated at Indian Institute of Technology Guwahati, Assam, India. The authors also acknowledge Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Czech Republic for the analytical support of this research work.
utb.wos.affiliation [Das, Munmi; Mudenur, Chethana; Mandal, Bishnupada; Katiyar, Vimal] Indian Inst Technol, Dept Chem Engn, Gauhati 781039, Assam, India; [Zandraa, Oyunchimeg; Saha, Nabanita; Saha, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic
utb.scopus.affiliation Department of Chemical Engineering, Indian Institute of Technology, Assam, Guwahati, 781039, India; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tř. T. Bati 5678, Zlín, 760 01, Czech Republic
utb.fulltext.projects -
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
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