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Gold-nickel nanowires as nanomotors for cancer marker biodetection and chemotherapeutic drug delivery

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dc.title Gold-nickel nanowires as nanomotors for cancer marker biodetection and chemotherapeutic drug delivery en
dc.contributor.author Karaca, Gozde Yurdabak
dc.contributor.author Kuralay, Filiz
dc.contributor.author Uygun, Emre
dc.contributor.author Özaltin, Kadir
dc.contributor.author Demirbuken, Sezin Eren
dc.contributor.author Garipcan, Bora
dc.contributor.author Oksuz, Lutfi
dc.contributor.author Oksuz, Aysegul Uygun
dc.relation.ispartof ACS Applied Nano Materials
dc.identifier.issn 2574-0970 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2021
utb.relation.volume 4
utb.relation.issue 4
dc.citation.spage 3377
dc.citation.epage 3388
dc.type article
dc.language.iso en
dc.publisher American Chemical Society
dc.identifier.doi 10.1021/acsanm.0c03145
dc.relation.uri https://pubs.acs.org/doi/10.1021/acsanm.0c03145
dc.subject nanowires as nanomotors en
dc.subject magnetic propulsion en
dc.subject microRNA-21 en
dc.subject doxorubicin en
dc.subject cancer cell en
dc.description.abstract Future biomedical applications of nanomachines require elimination of fuel requirements since most of the fuels have potential toxic effects. Herein, we report fuel-free magnetically powered gold-nickel (Au-Ni) nanowires as nanomotors for multipurpose biomedical applications. Fabrication of the nanowire-based nanomotors developed in this study is unique, and this protocol was dependent on the electrochemical preparation of Au nanowires followed by the direct current (DC) magnetron sputtering of Ni part. DC magnetron sputtering-based preparation used for the first time in the literature not only ensured homogeneous distribution and rapid deposition of the metal directly but also provided reproducible thin layers of magnetic Ni resulting in a significant improvement at nanomotor speeds. Besides magnetic propulsion, acoustic propulsion was also successfully applied. The effects of both propusion mechanisms were tested on the speed and direction of Au-Ni nanomotors. Biomedical applications of the motors accomplished in this study are rapid and sensitive detection of an important cancer biomarker microRNA-21 (miRNA-21) and pH-dependent and near-infrared (NIR) triggered release of a commonly used chemotherapeutic drug doxorubicin (DOX). Sensitive and selective miRNA-21 detection was achieved by using dye-labeled single-stranded DNA (ssDNA probe) modified Au-Ni nanomotors with a wide linear concentration range of 0.01 nM to 25 nM. Low detection limits of 2.9 pM and 1.6 pM were obtained for fluorescence and speed-based detection, respectively (n = 3). In addition, magnetically powered DOX-loaded Au-Ni nanomotors were guided on cancer cells (human breast cancer cell lines, MCF-7) in a controllable way for the efficient and controlled delivery of DOX. Cytotoxicity studies of the nanomotors presented negligible influence on the cell viability. © 2021 American Chemical Society. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1010321
utb.identifier.scopus 2-s2.0-85104927074
utb.identifier.wok 000644473900011
utb.source j-scopus
dc.date.accessioned 2021-05-14T12:05:20Z
dc.date.available 2021-05-14T12:05:20Z
dc.description.sponsorship Suleyman Demirel University BAP projectSuleyman Demirel University [FDK-2019-6769]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1150098]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Özaltin, Kadir
utb.fulltext.sponsorship Financial support was provided by Suleyman Demirel University BAP project (Project No: FDK-2019-6769). G.Y.K., F.K., E.U., L.O., and A.U.O. are also grateful to the Scientific and Technological Research Council of Turkey (Project No: 1150098 to Plazmatek) for their financial support. F.K. acknowledges Turkish Academy of Sciences (TÜBA) as an associate member.
utb.wos.affiliation [Karaca, Gozde Yurdabak] Suleyman Demirel Univ, Dept Bioengn, TR-32260 Isparta, Turkey; [Karaca, Gozde Yurdabak; Oksuz, Aysegul Uygun] Suleyman Demirel Univ, Dept Chem, TR-32260 Isparta, Turkey; [Uygun, Emre] Suleyman Demirel Univ, Dept Civil Engn, TR-32260 Isparta, Turkey; [Ozaltin, Kadir] Tomas Bata Univ Zlin, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Demirbuken, Sezin Eren; Garipcan, Bora] Bogazici Univ, Inst Biomed Engn, TR-32260 Istanbul, Turkey; [Oksuz, Lutfi] Suleyman Demirel Univ, Dept Phys, TR-32260 Isparta, Turkey; [Kuralay, Filiz] Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey
utb.scopus.affiliation Department of Bioengineering, Suleyman Demirel University, Isparta, 32260, Turkey; Department of Chemistry, Suleyman Demirel University, Isparta, 32260, Turkey; Department of Chemistry, Hacettepe University, Ankara, 06800, Turkey; Department of Civil Engineering, Suleyman Demirel University, Isparta, 32260, Turkey; Centre of Polymer Systems, Tomas Bata University in Zlin, Zlin, 76001, Czech Republic; Institute of Biomedical Engineering, Bogazici University, Istanbul, 32260, Turkey; Department of Physics, Suleyman Demirel University, Isparta, 32260, Turkey
utb.fulltext.projects FDK-2019-6769
utb.fulltext.projects 1150098
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