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Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

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dc.title Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends en
dc.contributor.author Karakurt, Ilkay
dc.contributor.author Özaltin, Kadir
dc.contributor.author Vargün, Elif
dc.contributor.author Kučerová, Liliana
dc.contributor.author Šuly, Pavol
dc.contributor.author Harea, Evghenii
dc.contributor.author Minařík, Antonín
dc.contributor.author Štěpánková, Kateřina
dc.contributor.author Lehocký, Marián
dc.contributor.author Humpolíček, Petr
dc.contributor.author Vesel, Alenka
dc.contributor.author Mozetic, Miran
dc.relation.ispartof Materials Science and Engineering C
dc.identifier.issn 0928-4931 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2021
utb.relation.volume 126
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.msec.2021.112125
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0928493121002642
dc.subject chitosan en
dc.subject vanillin en
dc.subject crosslinking en
dc.subject solvent casting en
dc.subject drug-polymer solubility en
dc.subject controlled drug release en
dc.subject transdermal delivery en
dc.description.abstract In transdermal drug delivery applications uniform drug distribution and sustained release are of great importance to decrease the side effects. In this direction in the present research, vanillin crosslinked chitosan (CS) and polyvinyl alcohol (PVA) blend based matrix-type transdermal system was prepared by casting and drying of aqueous solutions for local delivery of enrofloxacin (ENR) drug. Subsequently, the properties including the morphology, chemical structure, thermal behavior, tensile strength, crosslinking degree, weight uniformity, thickness, swelling and drug release of the CS-PVA blend films before and after crosslinking were characterized. In vitro drug release profiles showed the sustained release of ENR by the incorporation of vanillin as a crosslinker into the CS-PVA polymer matrix. Furthermore, the release kinetic profiles revealed that the followed mechanism for all samples was Higuchi and the increase of vanillin concentration in the blend films resulted in the change of diffusion mechanism from anomalous transport to Fickian diffusion. Overall, the obtained results suggest that the investigated vanillin crosslinked CS-PVA matrix-type films are potential candidates for transdermal drug delivery system. © 2021 en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1010312
utb.identifier.scopus 2-s2.0-85104802406
utb.identifier.wok 000663454000001
utb.source j-scopus
dc.date.accessioned 2021-05-14T12:05:19Z
dc.date.available 2021-05-14T12:05:19Z
dc.description.sponsorship Internal Grant Agency of Tomas Bata University in Zlin, Czech Republic [IGA/CPS/2021/001]; Ministry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [LTACH17015, RP/CPS/2020/001]; Slovenian Research Agency, SloveniaSlovenian Research Agency - Slovenia [L22616]; NPU Program I [LO1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Karakurt, Ilkay
utb.contributor.internalauthor Özaltin, Kadir
utb.contributor.internalauthor Vargün, Elif
utb.contributor.internalauthor Kučerová, Liliana
utb.contributor.internalauthor Šuly, Pavol
utb.contributor.internalauthor Harea, Evghenii
utb.contributor.internalauthor Minařík, Antonín
utb.contributor.internalauthor Štěpánková, Kateřina
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Humpolíček, Petr
utb.fulltext.sponsorship Authors thank the Internal Grant Agency of Tomas Bata University in Zlín, Czech Republic (IGA/CPS/2021/001), the Ministry of Education, Youth and Sports of the Czech Republic (project no. LTACH17015) and (project no. RP/CPS/2020/001), Slovenian Research Agency, Slovenia (project L2-2616), and NPU Program I (LO1504) for financial support.
utb.wos.affiliation [Karakurt, Ilkay; Ozaltin, Kadir; Vargun, Elif; Kucerova, Liliana; Suly, Pavol; Harea, Evghenii; Minarik, Antonin; Stepankova, Katerina; Lehocky, Marian; Humpolicek, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Trida Tomase Bati 5678, Zlin 76001, Czech Republic; [Vargun, Elif] Mugla Sitki Kocman Univ, Dept Chem, TR-48000 Kotekli, Mugla, Turkey; [Harea, Evghenii; Minarik, Antonin; Lehocky, Marian; Humpolicek, Petr] Tomas Bata Univ Zlin, Fac Technol, Vavreckova 275, Zlin 76001, Czech Republic; [Vesel, Alenka; Mozetic, Miran] Jozef Stefan Inst, Dept Surface Engn, Jamova Cesta 39, Ljubljana 1000, Slovenia
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, Zlin, 760 01, Czech Republic; Department of Chemistry, Mugla Sitki Kocman University, Kotekli, Mugla, 48000, Turkey; Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, Zlín, 76001, Czech Republic; Department of Surface Engineering, Jozef Stefan Institute, Jamova cesta 39, Ljubljana, 1000, Slovenia
utb.fulltext.projects IGA/CPS/2021/001
utb.fulltext.projects LTACH17015
utb.fulltext.projects RP/CPS/2020/001
utb.fulltext.projects L2-2616
utb.fulltext.projects LO1504
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