TBU Publications
Repository of TBU Publications

Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity

DSpace Repository

Show simple item record


dc.title Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity en
dc.contributor.author Kurtuldu, Fatih
dc.contributor.author Mutlu, Nurshen
dc.contributor.author Michálek, Martin
dc.contributor.author Zheng, Kai
dc.contributor.author Masař, Milan
dc.contributor.author Liverani, Liliana
dc.contributor.author Chen, Si
dc.contributor.author Galusek, Dušan
dc.contributor.author Boccaccini, Aldo R.
dc.relation.ispartof Materials Science & Engineering C-Materials For Biological Applications
dc.identifier.issn 0928-4931 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2021
utb.relation.volume 124
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.msec.2021.112050
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0928493121001892
dc.subject mesoporous bioactive glass nanoparticles en
dc.subject cerium en
dc.subject gallium en
dc.subject sol-gel method en
dc.subject antibacterial activity en
dc.description.abstract In recent years, mesoporous bioactive glass nanoparticles (MBGNPs) have generated great attention in biomedical applications. In this study, cerium and gallium doped MBGNPs were prepared by microemulsion assisted sol-gel method in the binary SiO2-CaO system. MBGNPs with spheroidal and pineal shaped morphology were obtained. Nitrogen sorption analysis elucidated the mesoporous structure of synthesized nanoparticles with high specific surface area. X-ray diffraction analysis confirmed the amorphous nature of the nanoparticles. The chemical compositions of all samples were determined by inductively coupled plasma-optical emission spectrometry (ICP-OES), which revealed that the contents of cerium and gallium could be tailored by adjusting the concentrations of the precursors used for the synthesis. All MBGNPs exhibited in vitro bioactivity when immersed in simulated body fluid, except the particles doped with higher amounts than 1 mol% of cerium. MBGNPs showed antibacterial activity against S. aureus and E. coli without exhibiting cytotoxicity towards MG-63 osteoblast-like cells. Mentioned features of the obtained Ce and Ga-doped MBGNPs make them useful for multifunctional applications such as drug delivery carriers or bioactive fillers for bone tissue engineering applications. © 2021 The Authors en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1010276
utb.identifier.obdid 43882506
utb.identifier.scopus 2-s2.0-85103647257
utb.identifier.wok 000647483000001
utb.source j-scopus
dc.date.accessioned 2021-04-14T13:37:58Z
dc.date.available 2021-04-14T13:37:58Z
dc.description.sponsorship European Union's Horizon 2020 research and innovation program [739566]; project "Centre of Polymer System plus" - Ministry of Education, Youth and Sports of the Czech Republic-Program NPU I [LO1504]; Ministry of Education, Youth and Sports of the Czech Republic -DKRVO [RP/CPS/2020/006]; [VEGA 1/0098/19]; [SAS-MOST JRP 2018/02]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Masař, Milan
utb.fulltext.sponsorship This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 739566. The financial support of this work by the grants VEGA 1/0098/19, and SAS-MOST JRP 2018/02 are gratefully acknowledged. Milan Masar appreciates the support from the project “Centre of Polymer System plus” funded by the Ministry of Education, Youth and Sports of the Czech Republic—Program NPU I (project number: LO1504) and also support by the Ministry of Education, Youth and Sports of the Czech Republic – DKRVO (RP/CPS/2020/006).
utb.wos.affiliation [Kurtuldu, Fatih; Mutlu, Nurshen; Michalek, Martin; Chen, Si; Galusek, Dusan] Alexander Dubcek Univ Trencin, FunGlass, Trencin 91150, Slovakia; [Kurtuldu, Fatih; Mutlu, Nurshen; Zheng, Kai; Liverani, Liliana; Boccaccini, Aldo R.] Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, D-91058 Erlangen, Germany; [Masar, Milan] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Galusek, Dusan] TnU AD, Ctr Funct & Surface Functionalized Glass, Joint Glass Ctr IIC SAS TnU AD & FChFT STU, Trencin, Slovakia
utb.scopus.affiliation FunGlass, Alexander Dubček University of Trenčín, Trenčín, 911 50, Slovakia; Institute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, Erlangen, 91058, Germany; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Zlin, 760 01, Czech Republic; Joint Glass Centre of the IIC SAS, TnU AD and FChFT STU, Centre for Functional and Surface Functionalized Glass, TnU AD, Trenčín, Slovakia
utb.fulltext.projects Horizon 2020
utb.fulltext.projects 739566
utb.fulltext.projects VEGA 1/0098/19
utb.fulltext.projects AS-MOST JRP 2018/02
utb.fulltext.projects LO1504
utb.fulltext.projects RP/CPS/2020/006
Find Full text

Files in this item

Show simple item record

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International