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Modulation of differentiation of embryonic stem cells by polypyrrole: The impact on neurogenesis

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dc.title Modulation of differentiation of embryonic stem cells by polypyrrole: The impact on neurogenesis en
dc.contributor.author Skopalová, Kateřina
dc.contributor.author Radaszkiewicz, Katarzyna Anna
dc.contributor.author Kašpárková, Věra
dc.contributor.author Stejskal, Jaroslav
dc.contributor.author Bober, Patrycja.
dc.contributor.author Junkar, Ita
dc.contributor.author Mozetič, Miran
dc.contributor.author Capáková, Zdenka
dc.contributor.author Lehocký, Marián
dc.contributor.author Kašparová, Martina
dc.contributor.author Pacherník, Jiří
dc.contributor.author Humpolíček, Petr
dc.relation.ispartof International Journal of Molecular Sciences
dc.identifier.issn 1661-6596 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2021
utb.relation.volume 22
utb.relation.issue 2
dc.citation.spage 1
dc.citation.epage 17
dc.type article
dc.language.iso en
dc.publisher MDPI AG
dc.identifier.doi 10.3390/ijms22020501
dc.relation.uri https://www.mdpi.com/1422-0067/22/2/501
dc.subject conducting polymer en
dc.subject polypyrrole en
dc.subject biocompatibility en
dc.subject neurogenesis en
dc.subject stem cells en
dc.description.abstract The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecularweight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1010175
utb.identifier.obdid 43882448
utb.identifier.scopus 2-s2.0-85099135097
utb.identifier.wok 000611321200001
utb.identifier.pubmed 33419082
utb.source j-scopus
dc.date.accessioned 2021-01-20T12:25:30Z
dc.date.available 2021-01-20T12:25:30Z
dc.description.sponsorship Czech Science FoundationGrant Agency of the Czech Republic [19-16861S, 17-05466S]; internal grant agency of Tomas Bata University in Zlin [IGA/CPS/2021/001]; Slovenian Research AgencySlovenian Research Agency - Slovenia [P2-0082]; Ministry of Education, Youth and Sports of the Czech Republic-DKRVO [RP/CPS/2020/001]
dc.description.sponsorship RP/CPS/2020/001; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Grantová Agentura České Republiky, GA ČR: 17-05466S, 19-16861S; Javna Agencija za Raziskovalno Dejavnost RS, ARRS: P2-0082; Univerzita Tomáše Bati ve Zlíně: IGA/CPS/2021/001
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Skopalová, Kateřina
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Kašparová, Martina
utb.contributor.internalauthor Humpolíček, Petr
utb.fulltext.affiliation Kateřina Skopalová 1, Katarzyna Anna Radaszkiewicz 2, Věra Kašpárková 1,3, Jaroslav Stejskal 4, Patrycja Bober 4, Ita Junkar 5, Miran Mozetič 5, Zdenka Capáková 1, Marián Lehocký 1,3, Martina Kašparová 1, Jiří Pacherník 2*, Petr Humpolíček 1,3* 1 Centre of Polymer Systems, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic; skopalova@utb.cz (K.S.); vkasparkova@utb.cz (V.K.); capakova@utb.cz (Z.C.); lehocky@utb.cz (M.L.); m3_kasparova@utb.cz (M.K.) 2 Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic; 432029@mail.muni.cz 3 Faculty of Technology, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic 4 Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic; stejskal@imc.cas.cz (J.S.); bober@imc.cas.cz (P.B.) 5 Department of Surface Engineering, Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia; ita.junkar@ijs.si (I.J.); miran.mozetic@ijs.si (M.M.) * Correspondence: jipa@sci.muni.cz (J.P.); humpolicek@utb.cz (P.H.)
utb.fulltext.dates Received: 9 December 2020 Accepted: 29 December 2020 Published: 6 January 2021
utb.fulltext.sponsorship This work was supported by Czech Science Foundation (19-16861S). Author J.P. thanks to Czech Science Foundation (Project 17-05466S). Author K.S. thanks the internal grant agency of Tomas Bata University in Zlín (IGA/CPS/2021/001). Authors I.J. and M.M. thank to Slovenian Research Agency (grant P2-0082). This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic—DKRVO (RP/CPS/2020/001).
utb.wos.affiliation [Skopalova, Katerina; Kasparkova, Vera; Capakova, Zdenka; Lehocky, Marian; Kasparova, Martina; Humpolicek, Petr] Tomas Bata Univ Zlin, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Radaszkiewicz, Katarzyna Anna; Pachernik, Jiri] Masaryk Univ, Fac Sci, Dept Expt Biol, Brno 62500, Czech Republic; [Kasparkova, Vera; Lehocky, Marian; Humpolicek, Petr] Tomas Bata Univ Zlin, Fac Technol, Zlin 76001, Czech Republic; [Stejskal, Jaroslav; Bober, Patrycja] Acad Sci Czech Republ, Inst Macromol Chem, Prague 16206 6, Czech Republic; [Junkar, Ita; Mozetic, Miran] Jozef Stefan Inst, Dept Surface Engn, Jamova Cesta 39, SI-1000 Ljubljana, Slovenia
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlín, Zlín, 760 01, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, 625 00, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Zlín, 760 01, Czech Republic; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague 6, 162 06, Czech Republic; Department of Surface Engineering, Jožef Stefan Institute, Jamova cesta 39, Ljubljana, SI-1000, Slovenia
utb.fulltext.projects 19-16861S
utb.fulltext.projects 17-05466S
utb.fulltext.projects IGA/CPS/2021/001)
utb.fulltext.projects P2-0082)RP/CPS/2020/001
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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