TBU Publications
Repository of TBU Publications

Effect of iron-oxide nanoparticles impregnated bacterial cellulose on overall properties of alginate/casein hydrogels: Potential injectable biomaterial for wound healing applications

DSpace Repository

Show simple item record


dc.title Effect of iron-oxide nanoparticles impregnated bacterial cellulose on overall properties of alginate/casein hydrogels: Potential injectable biomaterial for wound healing applications en
dc.contributor.author Patwa, Rahul
dc.contributor.author Zandraa, Oyunchimeg
dc.contributor.author Capáková, Zdenka
dc.contributor.author Saha, Nabanita
dc.contributor.author Sáha, Petr
dc.relation.ispartof Polymers
dc.identifier.issn 2073-4360 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 12
utb.relation.issue 11
dc.citation.spage 1
dc.citation.epage 21
dc.type article
dc.language.iso en
dc.publisher MDPI AG
dc.identifier.doi 10.3390/polym12112690
dc.relation.uri https://www.mdpi.com/2073-4360/12/11/2690
dc.subject hydrogel en
dc.subject alginate en
dc.subject bacterial cellulose en
dc.subject drug delivery en
dc.subject magnetic en
dc.description.abstract In this study we report the preparation of novel multicomponent hydrogels as potential biomaterials for injectable hydrogels comprised of alginate, casein and bacterial cellulose impregnated with iron nanoparticles (BCF). These hydrogels demonstrated amide cross-linking of alginate–casein, ionic cross-linking of alginate and supramolecular interaction due to incorporation of BCF. Incorporation of BCF into the hydrogels based on natural biopolymers was done to reinforce the hydrogels and impart magnetic properties critical for targeted drug delivery. This study aimed to improve overall properties of alginate/casein hydrogels by varying the BCF loading. The physico-chemical properties of gels were characterized via FTIR, XRD, DSC, TGA, VSM and mechanical compression. In addition, swelling, drug release, antibacterial activity and cytotoxicity studies were also conducted on these hydrogels. The results indicated that incorporation of BCF in alginate/casein hydrogels led to mechanically stronger gels with magnetic properties, increased porosity and hence increased swelling. A porous structure, which is essential for migration of cells and biomolecule transportation, was confirmed from microscopic analysis. The porous internal structure promoted cell viability, which was confirmed through MTT assay of fibroblasts. Moreover, a hydrogel can be useful for the delivery of essential drugs or biomolecules in a sustained manner for longer durations. These hydrogels are porous, cell viable and possess mechanical properties that match closely to the native tissue. Collectively, these hybrid alginate–casein hydrogels laden with BCF can be fabricated by a facile approach for potential wound healing applications. © MDPI AG. All rights reserved. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1010028
utb.identifier.obdid 43881866
utb.identifier.scopus 2-s2.0-85096229224
utb.identifier.wok 000593831600001
utb.identifier.pubmed 33202672
utb.source j-scopus
dc.date.accessioned 2020-11-27T13:06:28Z
dc.date.available 2020-11-27T13:06:28Z
dc.description.sponsorship Technology Agency of the Czech Republic (TACR)-M-ERA.NET [TH71020005]; Ministry of Education, Youth and Sports of the Czech Republic-DKRVO [RP/CPS/2020/005]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Patwa, Rahul
utb.contributor.internalauthor Zandraa, Oyunchimeg
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.affiliation Rahul Patwa 1*, Oyunchimeg Zandraa 1, Zdenka Capáková 1, Nabanita Saha 1,2*, Petr Sáha 1,2 1 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tř. T. Bati 5678, 760 01 Zlín, Czech Republic; zandraa@utb.cz (O.Z.); capakova@utb.cz (Z.C.); saha@utb.cz (P.S.) 2 Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, 760 01 Zlín, Czech Republic * Correspondence: patwa@utb.cz (R.P.); nabanita@utb.cz (N.S.)
utb.fulltext.dates Received: 23 October 2020 Accepted: 13 November 2020 Published: 14 November 2020
utb.fulltext.sponsorship This research work is supported by Technology Agency of the Czech Republic (TACR)—M-ERA.NET (TH71020005) and the Ministry of Education, Youth and Sports of the Czech Republic—DKRVO (RP/CPS/2020/005).
utb.wos.affiliation [Patwa, Rahul; Zandraa, Oyunchimeg; Capakova, Zdenka; Saha, Nabanita; Saha, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Tr T Bati 5678, Zlin 76001, Czech Republic; [Saha, Nabanita; Saha, Petr] Tomas Bata Univ Zlin, Fac Technol, Vavreckova 275, Zlin 76001, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tř. T. Bati 5678, Zlín, 760 01, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, Zlín, 760 01, Czech Republic
utb.fulltext.projects TH71020005
utb.fulltext.projects RP/CPS/2020/005
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty University Institute
utb.fulltext.faculty Faculty of Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
Find Full text

Files in this item

Show simple item record

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International