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Design of dialdehyde cellulose crosslinked poly(vinyl alcohol) hydrogels for transdermal drug delivery and wound dressings

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dc.title Design of dialdehyde cellulose crosslinked poly(vinyl alcohol) hydrogels for transdermal drug delivery and wound dressings en
dc.contributor.author Muchová, Monika
dc.contributor.author Münster, Lukáš
dc.contributor.author Capáková, Zdenka
dc.contributor.author Mikulcová, Veronika
dc.contributor.author Kuřitka, Ivo
dc.contributor.author Vícha, Jan
dc.relation.ispartof Materials Science & Engineering C-Materials For Biological Applications
dc.identifier.issn 0928-4931 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 116
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.msec.2020.111242
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0928493120312467
dc.subject poly(vinyl alcohol) en
dc.subject dialdehyde cellulose en
dc.subject transdermal en
dc.subject hydrogel en
dc.subject drug delivery en
dc.subject wound dressing en
dc.description.abstract 2,3-Dialdehyde cellulose (DAC) was used as an efficient and low-toxicity crosslinker to prepare thin PVA/DAC hydrogel films designed for topical applications such as drug-loaded patches, wound dressings or cosmetic products. An optimization of hydrogel properties was achieved by the variation of two factors – the amount of crosslinker and the weight-average molecular weight (Mw) of the source PVA. The role of each factor to network parameters, mechanical, rheological and surface properties, hydrogel porosity and transdermal absorption is discussed. The best results were obtained for hydrogel films prepared using 0.25 wt% of DAC and PVA with Mw = 130 kDa, which had a high porosity and drug-loading capacity (high water content), mechanical properties allowing easy handling, best adherence to the skin from all tested samples and improved transdermal drug-delivery. Hydrogel films are biocompatible, show no cytotoxicity and have no negative impact on cell growth and morphology in their presence. Furthermore, hydrogels do not support cell migration and attachment to their surface, which should ensure easy removal of hydrogel patches even from wounded or damaged skin after use. © 2020 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009798
utb.identifier.obdid 43881895
utb.identifier.scopus 2-s2.0-85087587373
utb.identifier.wok 000563934100007
utb.identifier.pubmed 32806291
utb.source j-scopus
dc.date.accessioned 2020-07-29T07:30:39Z
dc.date.available 2020-07-29T07:30:39Z
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic Program NPU I [LO1504]; Tomas Bata University in Zlin [IGA/CPS/2020/003]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Muchová, Monika
utb.contributor.internalauthor Münster, Lukáš
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Mikulcová, Veronika
utb.contributor.internalauthor Kuřitka, Ivo
utb.contributor.internalauthor Vícha, Jan
utb.fulltext.affiliation Monika Muchová, Lukáš Münster, Zdenka Capáková, Veronika Mikulcová, Ivo Kuřitka, Jan Vícha * Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, 760 01 Zlín, Czech Republic ⁎ Corresponding author. E-mail address: jvicha@utb.cz (J. Vícha).
utb.fulltext.dates Received 22 March 2020 Received in revised form 18 June 2020 Accepted 24 June 2020 Available online 26 June 2020
utb.fulltext.sponsorship This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic Program NPU I ( LO1504 ). M.M. was supported by the internal grant for specific research from Tomas Bata University in Zlín no. IGA/CPS/2020/003
utb.wos.affiliation [Muchova, Monika; Munster, Lukas; Capakova, Zdenka; Mikulcova, Veronika; Kuritka, Ivo; Vicha, Jan] Tomas Bata Univ Zlin, Ctr Polymer Syst, Tr Tomase Bati 5678, Zlin 76001, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, Zlín, 760 01, Czech Republic
utb.fulltext.projects LO1504
utb.fulltext.projects IGA/CPS/2020/003
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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