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Properties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates)

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dc.title Properties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates) en
dc.contributor.author Kovalčík, Adriána
dc.contributor.author Sangroniz, Leire
dc.contributor.author Kalina, Michal
dc.contributor.author Skopalová, Kateřina
dc.contributor.author Humpolíček, Petr
dc.contributor.author Omastová, Mária
dc.contributor.author Mundigler, Norbert
dc.contributor.author Müller, Alejandro J.
dc.relation.ispartof International Journal of Biological Macromolecules
dc.identifier.issn 0141-8130 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 161
dc.citation.spage 364
dc.citation.epage 376
dc.type article
dc.language.iso en
dc.publisher Elsevier B.V.
dc.identifier.doi 10.1016/j.ijbiomac.2020.06.022
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0141813020334590
dc.subject biodegradation en
dc.subject cytocompatibility en
dc.subject mechanical properties en
dc.subject poly(hydroxyalkanoates) en
dc.subject poly(lactic acid) en
dc.subject 3D printing en
dc.description.abstract Poly(hydroxyalkanoates) are biodegradable and biocompatible polymers suitable for tissue engineering. Fused deposition modeling (FDM) belongs to modern rapid prototyping techniques for the fabrication of scaffolds. In this work, poly(3-hydroxybutyrate (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH) were tested for FDM. Thermal and rheological properties of industrial PHAs were compared with poly(lactic acid) (PLA), which is a biodegradable polymer commonly used for FDM. The massive decrease in viscosity and loss of molecular weight of PHB and PHBV precluded their use for FDM. On the other hand, the thermal stability of PHBH was comparable to that of PLA. PHBH scaffolds prepared by FDM exhibited excellent mechanical properties, no cytotoxicity and large proliferation of mouse embryonic fibroblast cells within 96 h. The hydrolytic degradation of PHBH and PLA scaffolds tested in synthetic gastric juice for 52 days confirmed a faster degradation of PHBH than PLA. The decrease in molecular weight confirmed the first-order kinetics with a slightly higher (0.0169 day−1) degradation rate constant for PHBH as compared to the value (0.0107 day−1) obtained for PLA. These results indicate that PHBH could be used to produce scaffolds by FDM with application in tissue engineering. © 2020 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009757
utb.identifier.obdid 43881926
utb.identifier.scopus 2-s2.0-85086468826
utb.identifier.wok 000572832200006
utb.identifier.pubmed 32522546
utb.identifier.coden IJBMD
utb.source j-scopus
dc.date.accessioned 2020-06-24T08:32:16Z
dc.date.available 2020-06-24T08:32:16Z
dc.description.sponsorship project SoMoPro [6SA18032]; European Union's Horizon 2020 - Research and Innovation Framework Programme under the Marie Sklodowska-CurieEuropean Union (EU); Czech Science FoundationGrant Agency of the Czech Republic [19-16861S]; Basque GovernmentBasque Government [IT1309-19]; SouthMoravian RegionRegion Auvergne-Rhone-AlpesRegion Bourgogne-Franche-ComteRegion Hauts-de-FranceRegion Nouvelle-Aquitaine [665860]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Skopalová, Kateřina
utb.contributor.internalauthor Humpolíček, Petr
utb.fulltext.affiliation Adriana Kovalcik a*, Leire Sangroniz b, Michal Kalina c, Katerina Skopalova d, Petr Humpolíček d, Maria Omastova e, Norbert Mundigler f, Alejandro J. Müller b,g** a Department of Food Chemistry and Biotechnology, Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic b POLYMAT and Polymer Science and Technology Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia, San Sebastian, Spain c Department of Physical and Applied Chemistry, Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic d Centre of Polymer Systems, Faculty of Technology, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic e Polymer Institute, Slovak Academy of Sciences, Dubravska Cesta 9, 845 41 Bratislava 45, Slovak Republic f Department of Agrobiotechnology, IFA Tulln, Institute of Natural Materials Technology, University for Natural Resources and Life Sciences, Vienna, Konrad Lorenz Strasse 20, 3430 Tulln an der Donau, Austria g IKERBASQUE, Basque Foundation for Science, Bilbao, Spain ⁎ Correspondence to: Adriana Kovalcik, Department of Food Science and Biotechnology, Chemical Faculty, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic. ⁎⁎ Correspondence to: Alejandro J. Müller, POLYMAT and Polymer Science and Technology Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018. Donostia-San Sebastian, Spain and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. E-mail addresses: kovalcik@fch.vut.cz (A. Kovalcik), alejandrojesus.muller@ehu.es (A.J. Müller).
utb.fulltext.dates Received 28 March 2020 Received in revised form 31 May 2020 Accepted 2 June 2020 Available online 06 June 2020
utb.fulltext.sponsorship This work was funded through the project SoMoPro (project No. 6SA18032 ). This project has received funding from the European Union's Horizon 2020 - Research and Innovation Framework Programme under the Marie Skłodowska-Curie, and it is co-financed by the South Moravian Region under grant agreement No. 665860 . Authors KS and PH thank to the Czech Science Foundation ( 19-16861S ). AJM and LS acknowledge funding from the Basque Government through grant IT1309-19 . LS acknowledges postdoctoral grant from Basque Government. Note: Authors confirm that the content of this work reflects only the author's view and that the EU is not responsible for any use that may be made of the information it contains.
utb.wos.affiliation [Kovalcik, Adriana] Brno Univ Technol, Fac Chem, Dept Food Chem & Biotechnol, Purkynova 118, Brno 61200, Czech Republic; [Sangroniz, Leire; Muller, Alejandro J.] Univ Basque Country UPV EHU, Fac Chem, POLYMAT, Paseo Manuel Lordizabal 3, San Sebastian 20018, Spain; [Sangroniz, Leire; Muller, Alejandro J.] Univ Basque Country UPV EHU, Fac Chem, Polymer Sci & Technol Dept, Paseo Manuel Lordizabal 3, San Sebastian 20018, Spain; [Kalina, Michal] Brno Univ Technol, Dept Phys & Appl Chem, Fac Chem, Purkynova 118, Brno 61200, Czech Republic; [Skopalova, Katerina; Humpolicek, Petr] Tomas Bata Univ Zlin, Fac Technol, Ctr Polymer Syst, Trida Tomase Bali 5678, Zlin 760 01, Czech Republic; [Omastova, Maria] Slovak Acad Sci, Polymer Inst, Dubrayska Cesta 9, Bratislava 84541 45, Slovakia; [Mundigler, Norbert] Univ Nat Resources & Life Sci, IFA Tulln, Inst Nat Mat Technol, Dept Agrobiotechnol, Konrad Lorenz Str 20, A-3430 Vienna, Austria; [Muller, Alejandro J.] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain
utb.scopus.affiliation Department of Food Chemistry and Biotechnology, Faculty of Chemistry, Brno University of Technology, Purkynova 118, Brno, 612 00, Czech Republic; POLYMAT and Polymer Science and Technology Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, Donostia, San Sebastian, 20018, Spain; Department of Physical and Applied Chemistry, Faculty of Chemistry, Brno University of Technology, Purkynova 118, Brno, 612 00, Czech Republic; Centre of Polymer Systems, Faculty of Technology, Tomas Bata University in Zlin, Trida Tomase Bati 5678, Zlin, 760 01, Czech Republic; Polymer Institute, Slovak Academy of Sciences, Dubravska Cesta 9, Bratislava 45, 845 41, Slovakia; Department of Agrobiotechnology, IFA Tulln, Institute of Natural Materials Technology, University for Natural Resources and Life Sciences, Vienna, Konrad Lorenz Strasse 20, Tulln an der Donau, 3430, Austria; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
utb.fulltext.projects 6SA18032
utb.fulltext.projects 665860
utb.fulltext.projects 19-16861S
utb.fulltext.projects IT1309-19
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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