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Poly(2-oxazoline)-based magnetic hydrogels: Synthesis, performance and cytotoxicity

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dc.title Poly(2-oxazoline)-based magnetic hydrogels: Synthesis, performance and cytotoxicity en
dc.contributor.author Cvek, Martin
dc.contributor.author Zahoranová, Anna
dc.contributor.author Mrlík, Miroslav
dc.contributor.author Šrámková, Petra
dc.contributor.author Minařík, Antonín
dc.contributor.author Sedlačík, Michal
dc.relation.ispartof Colloids and Surfaces B: Biointerfaces
dc.identifier.issn 0927-7765 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 190
dc.type article
dc.language.iso en
dc.publisher Elsevier B.V.
dc.identifier.doi 10.1016/j.colsurfb.2020.110912
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0927776520301429
dc.subject Magnetic gel en
dc.subject Living cationic polymerization en
dc.subject Poly(2-oxazoline) en
dc.subject Biomaterial en
dc.subject Magnetorheology en
dc.subject Biomedical application en
dc.description.abstract Research on the subject of smart biomaterials has become a cornerstone of tissue engineering and regenerative medicine. Herein, the authors report on developing magnetic hydrogels that combine high biocompatibility and remarkable activity in magnetic fields. We fabricated magnetic hydrogels based on poly(2-ethyl-2-oxazoline) (POx) via living ring-opening cationic polymerization with in-situ embedding of the carbonyl iron (CI) particles. Investigation was made as to the effect exerted by the concentration of CI on magnetic, viscoelastic/magnetorheological properties, the degree of equilibrium swelling, and cytotoxicity. The hydrogels exhibited an open pore structure, as evidenced by computed tomography (CT) imaging. Susceptibility measurements revealed the concentration-dependent field-induced particle restructuration indicating elongation/contraction of the material, thereby determining the potential for magneto-mechanical stimulation of the cells. The POx-based magnetic hydrogels were amphiphilic in character, showing decrease in their capability to hold liquid alongside increase in CI concentration. Viscoelastic measurements suggested that interaction occurred between the particles and matrix based on inconsistency between the experimental storage modulus and the Krieger–Dougherty model. The synthesized materials exhibited excellent biocompatibility toward the 3T3 fibroblast cell line in tests of extract toxicity and direct contact cytotoxicity (ISO standards). The unique combination of properties exhibited by the material - magneto-mechanical activity and biocompatibility - could prove favorable in fields such as biomedicine and biomechanics. © 2020 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009617
utb.identifier.scopus 2-s2.0-85081121069
utb.identifier.wok 000530677200028
utb.identifier.pubmed 32172162
utb.identifier.coden CSBBE
utb.source j-scopus
dc.date.accessioned 2020-03-26T10:44:53Z
dc.date.available 2020-03-26T10:44:53Z
dc.description.sponsorship Czech Science FoundationGrant Agency of the Czech Republic [17-24730S]; Slovak Grant Agency VEGAVedecka grantova agentura MSVVaS SR a SAV (VEGA) [2/0124/18]; EU Funds - OP Research, Development and Education [CZ.02.2.69/0.0/0.0/16_027/0008464]; Ministry of Education, Youth and Sports, Czech RepublicMinistry of Education, Youth & Sports - Czech RepublicCzech Republic Government; Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Cvek, Martin
utb.contributor.internalauthor Mrlík, Miroslav
utb.contributor.internalauthor Minařík, Antonín
utb.contributor.internalauthor Sedlačík, Michal
utb.fulltext.sponsorship The authors M.C., M.M. and M.S. wish to thank the Czech Science Foundation [ 17-24730S ] for financial support. The author A.Z. and P.S. are grateful to the [project number 2/0124/18] from Slovak Grant Agency VEGA for financial support. The author M.C. further acknowledges [project number CZ.02.2.69/0.0/0.0/16_027/0008464] funded from the EU Funds – OP Research, Development and Education in cooperation with the Ministry of Education, Youth and Sports, Czech Republic . This work was supported also by the Ministry of Education, Youth and Sports of the Czech Republic – Program NPU I [LO1504]. The authors highly acknowledge Assoc. Prof. Miroslav Zahoran (Department of Experimental Physics, FMFI UK in Bratislava, Slovakia) for his help with SEM measurements, and Dr. Zuzana Kronekova (Polymer Institute, Slovak Academy of Sciences, Slovakia) for providing the biolab facility.
utb.wos.affiliation [Cvek, Martin; Mrlik, Miroslav; Minarik, Antonin; Sedlacik, Michal] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Trida T Bati 5678, Zlin 76001, Czech Republic; [Zahoranova, Anna; Sramkova, Petra] Slovak Acad Sci, Polymer Inst, Dubravska Cesta 9, Bratislava 84541, Slovakia; [Minarik, Antonin] Tomas Bata Univ Zlin, Fac Technol, Dept Phys & Mat Engn, Vavreckova 275, Zlin 76001, Czech Republic; [Sedlacik, Michal] Tomas Bata Univ Zlin, Fac Technol, Dept Prod Engn, Vavreckova 275, Zlin 76001, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Trida T. Bati 5678, Zlín, 760 01, Czech Republic; Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, 845 41, Slovakia; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, Zlín, 760 01, Czech Republic; Department of Production Engineering, Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, Zlín, 760 01, Czech Republic
utb.fulltext.projects 17-24730S
utb.fulltext.projects 2/0124/18
utb.fulltext.projects CZ.02.2.69/0.0/0.0/16_027/0008464
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