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Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy

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dc.title Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy en
dc.contributor.author Xiao, Haijun
dc.contributor.author Guo, Yiping
dc.contributor.author Liu, Hongmei
dc.contributor.author Liu, Yushi
dc.contributor.author Wang, Yumin
dc.contributor.author Li, Changqing
dc.contributor.author Císař, Jaroslav
dc.contributor.author Škoda, David
dc.contributor.author Kuřitka, Ivo
dc.contributor.author Guo, Li
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof Biomaterials
dc.identifier.issn 0142-9612 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 232
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.biomaterials.2019.119701
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0142961219308191
dc.subject Irinotecan en
dc.subject Curcumin en
dc.subject Charge conversion en
dc.subject Self-delivery en
dc.subject Targeting therapy en
dc.subject Diarrhea en
dc.description.abstract Various design and fabrication strategies of carrier-based drug delivery systems have been quickly established and applied for cancer therapy in recent years. These systems contribute greatly to current cancer treatments but further development needs to be made to eliminate obstacles such as low drug loading capacity and severe side effects. To achieve better drug delivery, we propose an innovative strategy for the construction of easy manufactured drug self-delivery systems based on molecular structures, which can be used for the co-delivery of curcuminoids and all the nitrogen-containing derivatives of camptothecin for better targeted cancer therapy with minimized side effects. The formation mechanism investigation demonstrates that the rigid planar structures of camptothecin derivatives and curcuminoids with relevant leaving hydrogens make it possible for them to be assembled into nanoparticles under suitable conditions. These nanoparticles show stabilized particle sizes (100 nm) under various conditions and tunable surface charges which increase from around −10 mV in a normal physiological condition (pH 7.4) to +40 mV under acidic tumor environments. In addition, in vivo mice experiments have demonstrated that, compared to irinotecan (a derivative of camptothecin) itself, the co-delivered irinotecan curcumin nanoparticles exhibited significantly enhanced lung and gallbladder targeting, improved macrophage-clearance escape and ameliorated colorectal cancer treatment with an eradication of life-threatening diarrhea, bringing hope for better targeted chemotherapy and clinical translation. Lastly, the strategy of structure based design of drug self-delivery systems may inspire more research and discoveries of similar self-delivered nano systems for wider pharmaceutical applications. © 2019 Elsevier Ltd en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009512
utb.identifier.obdid 43881932
utb.identifier.scopus 2-s2.0-85077147906
utb.identifier.wok 000514748200008
utb.identifier.pubmed 31901505
utb.identifier.coden BIMAD
utb.source j-scopus
dc.date.accessioned 2020-01-09T10:31:41Z
dc.date.available 2020-01-09T10:31:41Z
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [LO 1504]; Internal Grant Agency of the Tomas Bata University in Zlin [IGA/CPS/2017/005, IGA/CPS/2018/003, IGA/CPS/2019/006]; Fund for Fostering Talents in Basic Science of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China [J1310034-18]; Quantitative and Systems Biology program, University of California, Merced, United States
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Xiao, Haijun
utb.contributor.internalauthor Wang, Yumin
utb.contributor.internalauthor Císař, Jaroslav
utb.contributor.internalauthor Škoda, David
utb.contributor.internalauthor Kuřitka, Ivo
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Haijun Xiao a,1, Yiping Guo b,1, Hongmei Liu c, Yushi Liu c, Yumin Wang a, Changqing Li b,d, Jaroslav Císař a, David Škoda a, Ivo Kuřitka a, Li Guo c,e∗, Vladimír Sedlařík a∗∗ a Centre of Polymer Systems, Tomas Bata University in Zlin, Zlin, 76001, Czech Republic b Quantitative and Systems Biology Program, University of California, Merced, CA, 95343, USA c School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China d Department of Bioengineering, University of California, Merced, CA, 95343, USA e State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China ∗ Corresponding author. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. ∗∗ Corresponding author. Centre of Polymer Systems, Tomas Bata University in Zlin, Zlin, 76001, Czech Republic. E-mail addresses: guoli@cdutcm.edu.cn (L. Guo), sedlarik@utb.cz (V. Sedlařík). 1 Both authors contributed equally to this project.
utb.fulltext.dates Received 29 August 2019 Received in revised form 21 November 2019 Accepted 18 December 2019 Available online 19 December 2019
utb.fulltext.sponsorship We express our great appreciation to Jiayi Sun at Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, for the assistance with confocal laser scanning microscopy, Haojie Fei at Centre of Polymer Systems, Tomas Bata University in Zlin, for the help with scanning electron microscopy, Juanru Liu at School of Pharmacy, Chengdu University of Traditional Chinese Medicine, for the assistance during in vitro evaluation and all the technicians who helped us during this research. This work was co-funded by the Ministry of Education, Youth and Sports of the Czech Republic [Grant No. LO 1504 ]; Internal Grant Agency of the Tomas Bata University in Zlin [Grant No. IGA/CPS/2017/005 , Grant No. IGA/CPS/2018/003 , Grant No. IGA/CPS/2019/006 ]; Fund for Fostering Talents in Basic Science of the National Natural Science Foundation of China [ J1310034-18 ] and graduate student summer fellowship of Quantitative and Systems Biology program, University of California , Merced, United States. Appendix A
utb.wos.affiliation [Xiao, Haijun; Wang, Yumin; Cisar, Jaroslav; Skoda, David; Kuritka, Ivo; Sedlarik, Vladimir] Tomas Bata Univ Zlin, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Guo, Yiping; Li, Changqing] Univ Calif, Quantitat & Syst Biol Program, Merced, CA 95343 USA; [Liu, Hongmei; Liu, Yushi; Guo, Li] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China; [Li, Changqing] Univ Calif, Dept Bioengn, Merced, CA 95343 USA; [Guo, Li] Chengdu Univ Tradit Chinese Med, State Key Lab Characterist Chinese Med Resources, Chengdu 611137, Peoples R China
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlin, Zlin, 76001, Czech Republic; Quantitative and Systems Biology Program, University of California, Merced, CA 95343, United States; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Department of Bioengineering, University of California, Merced, CA 95343, United States; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China
utb.fulltext.projects LO 1504
utb.fulltext.projects IGA/CPS/2017/005
utb.fulltext.projects IGA/CPS/2018/003
utb.fulltext.projects IGA/CPS/2019/006
utb.fulltext.projects J1310034-18
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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