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Stabilization of chitosan-based polyelectrolyte nanoparticle cargo delivery biomaterials by a multiple ionic cross-linking strategy

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dc.title Stabilization of chitosan-based polyelectrolyte nanoparticle cargo delivery biomaterials by a multiple ionic cross-linking strategy en
dc.contributor.author Motiei, Marjan
dc.contributor.author Sedlařík, Vladimír
dc.contributor.author Lucia, Lucia A.
dc.contributor.author Fei, Haojie
dc.contributor.author Münster, Lukáš
dc.relation.ispartof Carbohydrate Polymers
dc.identifier.issn 0144-8617 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 231
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.carbpol.2019.115709
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0144861719313773
dc.subject Polyelectrolyte nanoparticles en
dc.subject Colloidal stability en
dc.subject Chitosan en
dc.subject Polyethyleneimine en
dc.subject Tripolyphosphate en
dc.subject Dextran sulfate en
dc.description.abstract PolyElectrolyte Nanoparticles (PENs) obtained by layer-by-layer self-assembly of polycations/polyanions suffer from a lack of colloidal stability in physiological conditions. We report a simple innovative approach for increasing their stability by multiple ionic cross-linkers. Herein, a chitosan-based core was stabilized by polyanions such as tripolyphosphate and dextran sulfate at pHs of 3 (aPENs) and 8 (bPENs) to improve the quality of electrostatic interactions in the core and manage self-assembly of polyethyleneimine shell onto the core. The physicochemical properties of the particles were characterized by DLS, SEM, TEM, FT-IR, and TGA. TEM micrographs showed visible core/shell structures of bPENs. From particle size and polydispersity indices, the bPENs stability was salt concentration-dependent. The release profiles of PENs using nicotinic acid demonstrated sustained release in a pH-independent manner with a good fit of Korsmeyer-Peppas model. These results suggest that multiple ionic cross-linkers can be an efficient approach to increase the colloidal stability of PENs. © 2019 Elsevier Ltd en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009487
utb.identifier.obdid 43881935
utb.identifier.scopus 2-s2.0-85076389952
utb.identifier.wok 000504650500049
utb.identifier.pubmed 31888842
utb.identifier.coden CAPOD
utb.source j-scopus
dc.date.accessioned 2020-01-07T08:12:33Z
dc.date.available 2020-01-07T08:12:33Z
dc.description.sponsorship Ministry of Education, Youth, and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [LO 1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Motiei, Marjan
utb.contributor.internalauthor Sedlařík, Vladimír
utb.contributor.internalauthor Fei, Haojie
utb.contributor.internalauthor Münster, Lukáš
utb.fulltext.sponsorship We gratefully acknowledge that this work was co-founded by the Ministry of Education, Youth, and Sports of the Czech Republic (Grant No. LO 1504).
utb.wos.affiliation [Motiei, Marjan; Sedlarik, Vladimir; Fei, Haojie; Munster, Lukas] Tomas Bata Univ Zlin, Ctr Polymer Syst, Trida Tomase Bati 5678, Zlin 76001, Czech Republic; [Lucia, Lucian A.] North Carolina State Univ, Chem, Dept Forest Biomat, Campus Boxes 8005,8204, Raleigh, NC 27695 USA; [Lucia, Lucian A.] Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Shandong, Peoples R China
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, Zlín, 76001, Czech Republic; Departments of Forest Biomaterials, Chemistry, Campus Boxes 8005, 8204, North Carolina State University, Raleigh, NC 27695, United States; State Key Laboratory of Bio-based Materials & Green Papermaking, Qilu University of Technology/Shandong Academy of Sciences, Jinan, 250353, China
utb.fulltext.projects LO 1504
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