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Calcium phosphate incorporated bacterial cellulose-polyvinylpyrrolidone based hydrogel scaffold: Structural property and cell viability study for bone regeneration application

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dc.title Calcium phosphate incorporated bacterial cellulose-polyvinylpyrrolidone based hydrogel scaffold: Structural property and cell viability study for bone regeneration application en
dc.contributor.author Basu, Probal
dc.contributor.author Saha, Nabanita
dc.contributor.author Alexandrova, Radostiha
dc.contributor.author Sáha, Petr
dc.relation.ispartof Polymers
dc.identifier.issn 2073-4360 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 11
utb.relation.issue 11
dc.type article
dc.language.iso en
dc.publisher MDPI AG
dc.identifier.doi 10.3390/polym11111821
dc.relation.uri https://www.mdpi.com/2073-4360/11/11/1821
dc.subject bacterial cellulose en
dc.subject calcium phosphate en
dc.subject hydrogel scaffolds en
dc.subject degradation en
dc.subject mechanical property en
dc.subject bone regeneration en
dc.description.abstract This work focuses on the analysis of structural and functional properties of calcium phosphate (CaP) incorporated bacterial cellulose (BC)-polyvinylpyrrolidone (PVP) based hydrogel scaffolds referred to as "CaP/BC-PVP". CaP is incorporated in the scaffolds in the form of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) in different concentrations (β-TCP: HA (w/w) = 20:80, 40:60, and 50:50). The scaffolds were characterized on the basis of porosity, thermal, biodegradation, mechanical, and cell viability/cytocompatibility properties. The structural properties of all the hydrogel scaffolds show significant porosity. The biodegradation of "CaP/BC-PVP" scaffold was evaluated following hydrolytic degradation. Weight loss profile, pH change, scanning electron microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR) study confirm the significant degradability of the scaffolds. It is observed that a 50:50_CaP/BC-PVP scaffold has the highest degree of degradation. On the other hand, the compressive strengths of CaP/BC-PVP hydrogel scaffolds are found between 0.21 to 0.31 MPa, which is comparable with the human trabecular bone. The cell viability study is performed with a human osteosarcoma Saos-2 cell line, where significant cell viability is observed in all the hydrogel scaffolds. This indicated their ability to facilitate cell growth and cell proliferation. Considering all these substantial properties, CaP/BC-PVP hydrogel scaffolds can be suggested for detailed investigation in the context of bone regeneration application. © 2019 by the authors. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009470
utb.identifier.obdid 43880787
utb.identifier.scopus 2-s2.0-85075547311
utb.identifier.wok 000503279200094
utb.identifier.pubmed 31698725
utb.source j-scopus
dc.date.accessioned 2019-12-20T12:39:21Z
dc.date.available 2019-12-20T12:39:21Z
dc.description.sponsorship Ministry of Education, Youth and Sports of The Czech Republic - NPU Program I [LO1504]; Internal Grant Agency, Tomas Bata University in Zlin, Czech Republic [IGA/CPS/2019/003]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Basu, Probal
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.sponsorship This work is mainly supported by the Ministry of Education, Youth and Sports of The Czech Republic – NPU Program I (LO1504) and the work was performed on the basis of a granted project of Internal Grant Agency (Project No. IGA/CPS/2019/003), Tomas Bata University in Zlin, Czech Republic. The authors would like to thank Boyka Andonova-Lilova (IEMPAM-BAS) for her sincere and kind help in this cytocompatibility study.
utb.wos.affiliation [Basu, Probal; Saha, Nabanita; Saha, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Alexandrova, Radostina] Bulgarian Acad Sci, Inst Expt Morphol Pathol & Anthropol Museum, BU-1113 Sofia, Bulgaria
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Zlín, 760 01, Czech Republic; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria
utb.fulltext.projects LO1504
utb.fulltext.projects IGA/CPS/2019/003
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Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International