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Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors

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dc.title Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors en
dc.contributor.author Maráková, Nela
dc.contributor.author Boeva, Zhanna A.
dc.contributor.author Humpolíček, Petr
dc.contributor.author Lindfors, Tom
dc.contributor.author Pacherník, Jiří
dc.contributor.author Kašpárková, Věra
dc.contributor.author Radaszkiewicz, Katarzyna Anna
dc.contributor.author Capáková, Zdenka
dc.contributor.author Minařík, Antonín
dc.contributor.author Lehocký, Marián
dc.relation.ispartof Materials Science and Engineering C
dc.identifier.issn 0928-4931 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 105
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.msec.2019.110029
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0928493119321563
dc.subject composites en
dc.subject graphene oxide en
dc.subject polypyrrole en
dc.subject PEDOT en
dc.subject cardiomyocytes en
dc.subject neural progenitors en
dc.description.abstract The cytocompatibility of cardiomyocytes derived from embryonic stem cells and neural progenitors, which were seeded on the surface of composite films made of graphene oxide (GO) and polypyrrole (PPy-GO) or poly(3,4-ethylenedioxythiophene) (PEDOT-GO) are reported. The GO incorporated in the composite matrix contributes to the patterning of the composite surface, while the electrically conducting PPy and PEDOT serve as ion-to-electron transducers facilitating electrical stimulation/sensing. The films were fabricated by a simple one-step electropolymerization procedure on electrically conducting indium tin oxide (ITO) and graphene paper (GP) substrates. Factors affecting the cell behaviour, i.e. the surface topography, wettability, and electrical surface conductivity, were studied. The PPy-GO and PEDOT-GO prepared on ITO exhibited high surface conductivity, especially in the case of the ITO/PPy-GO composite. We found that for cardiomyocytes, the PPy-GO and PEDOT-GO composites counteracted the negative effect of the GP substrate that inhibited their growth. Both the PPy-GO and PEDOT-GO composites prepared on ITO and GP significantly decreased the cytocompatibility of neural progenitors. The presented results enhance the knowledge about the biological properties of electroactive materials, which are critical for tissue engineering, especially in context stimuli-responsive scaffolds. © 2019 Elsevier B.V. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1009025
utb.identifier.obdid 43880561
utb.identifier.scopus 2-s2.0-85070369404
utb.identifier.wok 000490044700047
utb.source j-scopus
dc.date.accessioned 2019-08-21T11:43:44Z
dc.date.available 2019-08-21T11:43:44Z
dc.description.sponsorship Czech Science FoundationGrant Agency of the Czech Republic [19168615]; Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [L01504]; Jane and Aatos Erkko Foundation (Finland)
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Maráková, Nela
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Minařík, Antonín
utb.contributor.internalauthor Lehocký, Marián
utb.fulltext.affiliation Nela Maráková a,b, Zhanna A. Boeva c, Petr Humpolíček a,b*, Tom Lindfors c*, Jiří Pacherník d, Věra Kašpárková a,b, Katarzyna Anna Radaszkiewicz d, Zdenka Capáková a, Antonín Minařík a,b, Marián Lehocký a,b a Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic b Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic c Åbo Akademi University, Faculty of Science and Engineering, Johan Gadolin Process Chemistry Centre (PCC), Laboratory of Analytical Chemistry, Biskopsgatan 8, 20500 Åbo, Finland d Institute of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic * Corresponding authors. E-mail addresses: humpolicek@utb.cz (P. Humpolíček), tom.lindfors@abo.fi (T. Lindfors).
utb.fulltext.dates Received 11 June 2019 Received in revised form 23 July 2019 Accepted 28 July 2019 Available online 29 July 2019
utb.fulltext.sponsorship This work was supported by the Czech Science Foundation (19-16861S), and by the Ministry of Education, Youth and Sports of the Czech Republic – Program NPU I (LO1504). Zhanna A. Boeva gratefully acknowledges financial support from the Jane and Aatos Erkko Foundation (Finland).
utb.wos.affiliation [Marakova, Nela; Humpolicek, Petr; Kasparkova, Vera; Capakova, Zdenka; Minarik, Antonin; Lehocky, Marian] Tomas Bata Univ Zlin, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Marakova, Nela; Humpolicek, Petr; Kasparkova, Vera; Minarik, Antonin; Lehocky, Marian] Tomas Bata Univ Zlin, Fac Technol, Zlin 76001, Czech Republic; [Boeva, Zhanna A.; Lindfors, Tom] Abo Akad Univ, Fac Sci & Engn, Johan Gadolin Proc Chem Ctr PCC, Lab Analyt Chem, Biskopsgatan 8, SF-20500 Turku, Finland; [Pachernik, Jiri; Radaszkiewicz, Katarzyna Anna] Masaryk Univ, Fac Sci, Inst Expt Biol, Brno 62500, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlin, Zlin, 760 01, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, Zlin, 760 01, Czech Republic; Åbo Akademi University, Faculty of Science and Engineering, Johan Gadolin Process Chemistry Centre (PCC), Laboratory of Analytical Chemistry, Biskopsgatan 8, Åbo, 20500, Finland; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, 625 00, Czech Republic
utb.fulltext.projects 19-16861S
utb.fulltext.projects LO1504
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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