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Exploring the critical factors limiting polyaniline biocompatibility

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dc.title Exploring the critical factors limiting polyaniline biocompatibility en
dc.contributor.author Kašpárková, Věra
dc.contributor.author Humpolíček, Petr
dc.contributor.author Stejskal, Jaroslav
dc.contributor.author Capáková, Zdenka
dc.contributor.author Bober, Patrycja
dc.contributor.author Skopalová, Kateřina
dc.contributor.author Lehocký, Marián
dc.relation.ispartof Polymers
dc.identifier.issn 2073-4360 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 11
utb.relation.issue 2
dc.type article
dc.language.iso en
dc.publisher Mdpi
dc.identifier.doi 10.3390/polym11020362
dc.relation.uri https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419196/
dc.subject polyaniline en
dc.subject monomer en
dc.subject oligomer en
dc.subject impurity profile en
dc.subject cytotoxicity en
dc.description.abstract Today, the application of polyaniline in biomedicine is widely discussed. However, information about impurities released from polyaniline and about the cytotoxicity of its precursors aniline, aniline hydrochloride, and ammonium persulfate are scarce. Therefore, cytotoxicity thresholds for the individual precursors and their combinations were determined (MTT assay) and the type of cell death caused by exposition to the precursors was identified using flow-cytometry. Tests on fibroblasts revealed higher cytotoxicity of ammonium persulfate than aniline hydrochloride. Thanks to the synergic effect, both monomers in combination enhanced their cytotoxicities compared with individual substances. Thereafter, cytotoxicity of polyaniline doped with different acids (sulfuric, nitric, phosphoric, hydrochloric, and methanesulfonic) was determined and correlated with impurities present in respective sample (HPLC). The lowest cytotoxicity showed polyaniline doped with phosphoric acid (followed by sulfuric, methanesulfonic, and nitric acid). Cytotoxicity of polyaniline was mainly attributed to the presence of residual ammonium persulfate and low-molecular-weight polar substances. This is crucial information with respect to the purification of polyaniline and production of its cytocompatible form. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1008555
utb.identifier.obdid 43880417
utb.identifier.scopus 2-s2.0-85069828924
utb.identifier.wok 000460296000176
utb.source j-wok
dc.date.accessioned 2019-07-08T11:59:54Z
dc.date.available 2019-07-08T11:59:54Z
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic [LO1504]; Czech Science Foundation [17-05095S]; Tomas Bata University in Zlin [IGA/CPS/2019/004]
dc.rights Attribution 4.0 International
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.ou Department of Fat, Surfactant and Cosmetics Technology
utb.ou Polymer Centre
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Skopalová, Kateřina
utb.contributor.internalauthor Lehocký, Marián
utb.fulltext.affiliation Věra Kašpárková 1,2, Petr Humpolíček 1,3*, Jaroslav Stejskal 4, Zdenka Capáková 1, Patrycja Bober 4, Kateřina Skopalová 1, Marián Lehocký 1,2 1 Centre of Polymer Systems, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic; vkasparkova@utb.cz (V.K.); capakova@utb.cz (Z.C.); skopalova@utb.cz (K.S.); lehocky@utb.cz (M.L.) 2 Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlin, T.G.M. Sq. 5555, 760 01 Zlin, Czech Republic 3 Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, T.G.M. Sq. 5555, 760 01 Zlin, Czech Republic 4 Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic; stejskal@imc.cas.cz (J.S.); bober@imc.cas.cz (P.B.) * Correspondence: humpolicek@utb.cz
utb.fulltext.dates Received: 16 January 2019 Accepted: 14 February 2019 Published: 19 February 2019
utb.wos.affiliation [Kasparkova, Vera; Humpolicek, Petr; Capakova, Zdenka; Skopalova, Katerina; Lehocky, Marian] Tomas Bata Univ Zlin, Ctr Polymer Syst, Tr T Bali 5678, Zlin 76001, Czech Republic; [Kasparkova, Vera; Lehocky, Marian] Tomas Bata Univ Zlin, Fac Technol, Dept Fat Surfactant & Cosmet Technol, TGM Sq 5555, Zlin 76001, Czech Republic; [Humpolicek, Petr] Tomas Bata Univ Zlin, Polymer Ctr, Fac Technol, TGM Sq 5555, Zlin 76001, Czech Republic; [Stejskal, Jaroslav; Bober, Patrycja] Czech Acad Sci, Inst Macromol Chem, Heyrovsky Sq 2, Prague 16206 6, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlin, Tr. T. Bati 5678, Zlin, 760 01, Czech Republic; Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlin, T.G.M. Sq. 5555, Zlin, 760 01, Czech Republic; Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, T.G.M. Sq. 5555, Zlin, 760 01, Czech Republic; Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky Sq. 2, Prague 6, 162 06, Czech Republic
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Department of Fat, Surfactant and Cosmetics Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Polymer Centre
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Department of Fat, Surfactant and Cosmetics Technology
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