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Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)-block-poly(oxirane)-based nanofibrous electrospun polyester–ether–urethanes used as potential drug-delivery system

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dc.title Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)-block-poly(oxirane)-based nanofibrous electrospun polyester–ether–urethanes used as potential drug-delivery system en
dc.contributor.author Pavelková, Alena
dc.contributor.author Kucharczyk, Pavel
dc.contributor.author Capáková, Zdenka
dc.contributor.author Peer, Petra
dc.contributor.author Pummerová, Martina
dc.contributor.author Zedník, Jiří
dc.contributor.author Vohlídal, Jiří
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof Journal of Biomedical Materials Research - Part B Applied Biomaterials
dc.identifier.issn 1552-4973 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 107
utb.relation.issue 7
dc.citation.spage 2378
dc.citation.epage 2387
dc.type article
dc.language.iso en
dc.publisher John Wiley and Sons Inc.
dc.identifier.doi 10.1002/jbm.b.34331
dc.subject poly(lactic acid) en
dc.subject polyester-urethanes en
dc.subject electrospinning en
dc.subject drug delivery en
dc.subject abiotic en
dc.subject degradation en
dc.subject nanofibers en
dc.subject vancomycin en
dc.description.abstract Poly(lactic acid)-block-poly(oxirane)s (PLA-b-POE) of various compositions were prepared using a one-pot approach and then extended in a reaction with l-lysine diethyl ester diisocyanate, thereby forming polyester–ether–urethanes (PEU) with prolonged chains and units with increased degradability. The PEUs are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin (VAC). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEUs. Therefore, our findings provide an effective approach to tuning the functional properties of these advanced biocompatible materials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res B Part B, 2019. © 2019 Wiley Periodicals, Inc. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008517
utb.identifier.obdid 43880409
utb.identifier.scopus 2-s2.0-85060786373
utb.identifier.wok 000483702000018
utb.identifier.coden JBMRG
utb.source j-scopus
dc.date.accessioned 2019-07-08T11:59:53Z
dc.date.available 2019-07-08T11:59:53Z
dc.description.sponsorship Grantova Agentura Ceske RepublikyGrant Agency of the Czech Republic [15-08287Y]; RVO [67985874., 67985874]; Czech Science FoundationGrant Agency of the Czech Republic [15-08287Y]; Ministry of Education, Youth and Sports of the Czech Republic within the NPU I programme [CZ. 1.05/2.1.00/19.0409, LO1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Pavelková, Alena
utb.contributor.internalauthor Kucharczyk, Pavel
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Pummerová, Martina
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Alena Pavelková 1, Pavel Kucharczyk 1, Zdenka Capáková 1, Petra Peer 2, Martina Pummerová 1, Jiří Zedník 3, Jiří Vohlídal 3, Vladimír Sedlařík 1 1 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Zlin, 76001, Czech Republic 2 Institute of Hydrodynamics of the Czech Academy of Sciences, Prague 6, 16672, Czech Republic 3 Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague 2, CZ-12840, Czech Republic
utb.fulltext.dates Received 17 August 2018 revised 21 December 2018 accepted 13 January 2019 Published online 28 January 2019
utb.wos.affiliation [Pavelkova, Alena; Kucharczyk, Pavel; Capakova, Zdenka; Pummerova, Martina; Sedlarik, Vladimir] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Peer, Petra] Czech Acad Sci, Inst Hydrodynam, Prague 16672 6, Czech Republic; [Zednik, Jiri; Vohlidal, Jiri] Charles Univ Prague, Fac Sci, Dept Phys & Macromol Chem, CZ-12840 Prague 2, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Zlin, 76001, Czech Republic; Institute of Hydrodynamics of the Czech Academy of Sciences, Prague 6, 16672, Czech Republic; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague 2, CZ-12840, Czech Republic
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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