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Multidrug delivery system based on polysaccharide nanocomplexes for controlled delivery of a combination of chemotherapeutics

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dc.title Multidrug delivery system based on polysaccharide nanocomplexes for controlled delivery of a combination of chemotherapeutics en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Özaltin, Kadir
dc.contributor.author Trusova, Marina E.
dc.contributor.author Postnikov, Pavel S.
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof Journal of Drug Delivery Science and Technology
dc.identifier.issn 1773-2247 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 50
dc.citation.spage 90
dc.citation.epage 98
dc.type article
dc.language.iso en
dc.publisher Editions de Sante
dc.identifier.doi 10.1016/j.jddst.2019.01.003
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1773224718309109
dc.subject 5-Fluorouracil en
dc.subject 5-Fluorouracil (PubChem CID: 3385) en
dc.subject Alginic acid en
dc.subject Chitosan en
dc.subject Chitosan (PubChem CID: 71853) en
dc.subject Combination therapy en
dc.subject Doxorubicin en
dc.subject Doxorubicin hydrochloride (PubChem CID: 443939) en
dc.subject Nanocomplexes en
dc.subject Polysaccharides en
dc.description.abstract Development of delivery systems able to hold and release a combination of bioactive compounds at the target site represents a strategy for improving the therapeutic outcomes and overcome the central issues in the multitherapeutic approach. A delivery system based on polysaccharides suitable for loading a combination of chemotherapeutic drugs, doxorubicin and 5-fluorouracil, at defined weight ratio and deliver them following a pH-dependent kinetics was developed. Nanocomplexes were prepared by polyelectrolytes complexation and characterised in terms of average dimension, morphology, drug content by dynamic light scattering, transmission and scanning microscope and UV–Vis spectroscopy, respectively. The complexes showed a spherical shape with the hydrodynamic diameter between 100 and 130 nm, positive ς-potential, high stability in physiological environment and up to 800 μg of drugs per mg loaded. Release studies demonstrate a pH-dependent trend with high control of the release rate for each compound. In vitro hemocompatibility and not cytotoxicity were observed. In vitro studies showed a significate reduction of the cell viability after contact with the dual-drug loaded complexes than the single-loaded and free-drug formulations demonstrating the synergic effect of the drugs and the advantages of using the complexes. The results show the potential application of the nanosystems for multiple-drug delivery in therapy. © 2019 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008457
utb.identifier.obdid 43880395
utb.identifier.scopus 2-s2.0-85060253634
utb.identifier.wok 000461717000011
utb.identifier.coden JDDSA
utb.source j-scopus
dc.date.accessioned 2019-07-08T11:59:48Z
dc.date.available 2019-07-08T11:59:48Z
dc.description.sponsorship Tomsk Polytechnic University [VIU-RSCABS-89/2018]; Ministry of Education, Youth and Sports of the Czech Republic; NPU [LO1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Özaltin, Kadir
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Antonio Di Martino a,b*, Kadir Ozaltin a, Marina E. Trusova b, Pavel S. Postnikov b, Vladimir Sedlarik a a Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01, Zlin, Czech Republic b Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Av. 30, 634050, Tomsk, Russian Federation ∗ Corresponding author. Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01, Zlin, Czech Republic. E-mail addresses: dimartino@utb.cz, dimartino@tpu.ru (A. Di Martino).
utb.fulltext.dates Received 13 August 2018 Received in revised form 10 December 2018 Accepted 4 January 2019 Available online 06 January 2019
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, Zlin, 760 01, Czech Republic; Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Av. 30, Tomsk, 634050, Russian Federation
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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