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PVP - CMC hydrogel: An excellent bioinspired and biocompatible scaffold for osseointegration

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dc.title PVP - CMC hydrogel: An excellent bioinspired and biocompatible scaffold for osseointegration en
dc.contributor.author Saha, Nabanita
dc.contributor.author Shah, Rushita
dc.contributor.author Gupta, Prerak
dc.contributor.author Mandal, Biman B.
dc.contributor.author Alexandrova, Radostina I.
dc.contributor.author Sikirić, Maja Dutour
dc.contributor.author Sáha, Petr
dc.relation.ispartof Materials Science and Engineering C
dc.identifier.issn 0928-4931 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 95
dc.citation.spage 440
dc.citation.epage 449
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.msec.2018.04.050
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0928493117302758
dc.subject Biocompatibility en
dc.subject Biomaterials en
dc.subject Biomineralization en
dc.subject Cell cultures en
dc.subject Mechanical properties en
dc.subject Osseointegration en
dc.subject PVP-CMC CaCO3 composites en
dc.description.abstract Fabrication of porous and biologically inspired biomaterials that mimic the formation of microstructural structures of nacre in the form of calcite (CaCO3) and evaluation of the biocompatibility of such organic-inorganic composite scaffold for bone tissue engineering, are focus of this paper. Nacre's self-assembly characteristics are concerned about the development of calcite filled biomineralized scaffold following the nature based biomineralization process and biomimetic applications. The PVP-CMC hydrogel film, comprised of PVP:0.2, CMC:0.8, PEG:1.0, Agar:2.0, Glycerene:1.0 and water:95.0 w/v%; acts as catalyst and template for the nucleation and growth of the inorganic CaCO3 within the scaffold. The PVP-CMC hydrogel (in the dry state) was immersed in ionic solutions (g/100 ml) of Na2CO3 and CaCl2·H2O in different concentrations sets i.e. Set-1: 10.50/14.70; Set-2: 5.25/7.35; Set-3: 4.20/5.88; Set-4: 2.10/2.94; Set-5: 1.05/1.47, Set-6: 0.55/0.55 for 90 min. As a result, “PVP-CMC-CaCO3” hydrogel scaffold was fabricated having bio-inspired structural and functional properties. Cell proliferation and cell viability were examined until 7 days in the presence of “PVP-CMC-CaCO3” scaffolds using permanent cell lines MG63 (human osteosarcoma), L929 (murine fibroblasts) as well as cultures from mouse bone explants (CC-MBE), confirmed that the said hydrogel scaffolds are biocompatible. But, from mechanical strength as well as biocompatibility point of view, scaffolds prepared in Set-1 to 3 ionic solutions were superior. In conclusion, these three calcite filled hydrogel scaffolds are recommended and can be used for osseointegration. © 2018 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008393
utb.identifier.obdid 43880354
utb.identifier.scopus 2-s2.0-85045750009
utb.identifier.wok 000455858300047
utb.identifier.pubmed 30573269
utb.source j-scopus
dc.date.accessioned 2019-01-31T08:58:59Z
dc.date.available 2019-01-31T08:58:59Z
dc.description.sponsorship Tomas Bata University in Zlin [IGA/FT/2014/015]; Ministry of Education, Youth and Sports of the Czech Republic-Program NPUI [LO1504]; Fund "Scientific Research", Bulgarian Ministry of Education and Science [(sic)02-30/2014]; Department of Biotechnology (DBT); Department of Science and Technology (DST), Government of India; COST Action [MP1301]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Shah, Rushita
utb.contributor.internalauthor Sáha, Petr
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlin, Tř. T. Bati 5678, Zlin, 760 01, Czech Republic; Biomaterial and Tissue Engineering Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Assam 781 039, India; Department of Pathology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, Sofia, 1113, Bulgaria; Department of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54, Zagreb, 10000, Croatia
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