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Novel biopolimeric system for bone tissue engineering: Crosslinked and plasticized chitosan/poly vinyl alcohol/hydroxiapatite scaffolds

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dc.title Novel biopolimeric system for bone tissue engineering: Crosslinked and plasticized chitosan/poly vinyl alcohol/hydroxiapatite scaffolds en
dc.contributor.author Castillo, Sergio Andres Pineda
dc.contributor.author Lopez, Cristian Camilo Bernal
dc.contributor.author Araujo, Favio Andres Tovar
dc.contributor.author Bernal Ballén, Andrés
dc.contributor.author Segura-Puello, Hugo Ramiro
dc.contributor.author Nieto-Mosquera, Diana Lorena
dc.contributor.author Muñoz-Forero, Diana Milena
dc.contributor.author Guitarrero-Bustos, Sandra Viviana
dc.contributor.author Villamil-Ballesteros, Andrea Catalina
dc.contributor.author Münster, Lukáš
dc.relation.ispartof 2018 9th International Seminar of Biomedical Engineering, SIB 2018 - Conference Proceedings
dc.identifier.isbn 9781538670088
dc.date.issued 2018
dc.event.title 9th International Seminar of Biomedical Engineering, SIB 2018
dc.event.location Bogota
utb.event.state-en Colombia
utb.event.state-cs Kolumbie
dc.event.sdate 2018-05-16
dc.event.edate 2018-05-18
dc.type conferenceObject
dc.language.iso en
dc.publisher Institute of Electrical and Electronics Engineers Inc.
dc.identifier.doi 10.1109/SIB.2018.8467728
dc.relation.uri https://ieeexplore.ieee.org/document/8467728
dc.subject chitosan en
dc.subject polyvinyl alcohol en
dc.subject hydroxiapatite en
dc.subject tissue engineering en
dc.subject bone regeneration en
dc.description.abstract Porous scaffolds made of chitosan, polyvinyl alcohol and hydroxyapatite were prepared via freeze-drying method. In this matter, three different volume ratios of polymer solutions (1:1, 1:3, 3:1) and constant hydroxyapatite mass ratio were blended. Glutaraldehyde and glycerol were added as a polymer-chain crosslinker and plasticizer, respectively. The obtained scaffolds were used to test bone proliferation and potential for bone regeneration and they were characterized through FTIR, mechanical tests, cell cultures and swelling tests. Every quantitative measurement was statistically tested using two-way analysis of variance (ANOVA) with < 0.05. Partial results from cell culture have been obtained, showing faster cell differentiation in the scaffolds combined with glutaraldehyde and glycerol. Crosslinked scaffolds showed better swelling conditions than those that were not subject to this chemical reaction. Besides, samples with higher chitosan ratio exhibited better swelling behavior. Experiments suggest that the bio-polymeric system has potential for bone tissue regeneration. © 2018 IEEE. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008354
utb.identifier.obdid 43879372
utb.identifier.scopus 2-s2.0-85055468655
utb.identifier.wok 000482875700005
utb.source d-scopus
dc.date.accessioned 2019-01-03T12:31:47Z
dc.date.available 2019-01-03T12:31:47Z
dc.description.sponsorship Universidad Manuela Beltran (Bogota, Colombia); Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Münster, Lukáš
utb.fulltext.affiliation Sergio Andrés Pineda Castillo 1, Cristian Camilo Bernal López 2, Favio Andrés Tovar Araújo 3, Andrés Bernal-Ballén 4, Hugo Ramiro Segura-Puello 5, Diana Lorena NietoMosquera 6, Diana Milena Muñoz-Forero 7, Sandra Viviana Guitarrero-Bustos 8, Andrea Catalina Villamil-Ballesteros 9, Lukas Munster 10 Grupo de Investigación en Ingeniería Biomédica Vicerrectoría de Investigaciones. Universidad Manuela Beltrán Avenida Circunvalar No. 60-00. Bogotá, Colombia sergioapc_gtr@hotmail.com 1; bernalip10@hotmail.com 2; dstm.0105@gmail.com 3; andres.bernal@docentes.umb.edu.co 4; Laboratorio de Investigación en Salud. Universidad Manuela Beltrán. Avenida Circunvalar No. 60-00. Bogotá, Colombia hugo.segura@umb.edu.co 5; diana.nieto@umb.edu.co 6; diana.munoz@umb.edu.co 7; sandra.guitarrero@umb.edu.co 8; andrea.villamil@umb.edu.co 9; Centre of Polymer Systems, University Institute. Tomas Bata University in Zlin. Trida Tomase Bati, 5678, 76001 Zlin, Czech Republic munster@cps.utb.cz10
utb.fulltext.dates -
utb.wos.affiliation [Pineda Castillo, Sergio Andres; Bernal Lopez, Cristian Camilo; Tovar Araujo, Favio Andres; Bernal-Ballen, Andres] Univ Manuela Beltran, Grp Invest Ingn Biomed Vicerrectoria Invest, Ave Circunvalar 60-00, Bogota, Colombia; [Ramiro Segura-Puello, Hugo; Lorena Nieto-Mosquera, Diana; Milena Munoz-Forero, Diana; Viviana Guitarrero-Bustos, Sandra; Catalina Villamil-Ballesteros, Andrea] Univ Manuela Beltran, Lab Invest Salud, Ave Circunvalar 60-00, Bogota, Colombia; [Munster, Lukas] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Trida Tomase Bati 5678, Zlin 76001, Czech Republic
utb.scopus.affiliation Grupo de Investigación en Ingeniería Biomédica, Vicerrectoría de Investigaciones, Universidad Manuela, Beltrán, Colombia; Avenida Circunvalar No. 60-00, Bogotá, Colombia, Colombia; Laboratorio de Investigación en Salud, Universidad Manuela Beltrán, Bogotá, No. 60-00, Colombia; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati, 5678, Zlin, 76001, Czech Republic
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
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