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Grafting of magnetic particles with poly(2-isopropenyl-2-oxazoline)

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dc.title Grafting of magnetic particles with poly(2-isopropenyl-2-oxazoline) en
dc.contributor.author Cvek, Martin
dc.contributor.author Mrlík, Miroslav
dc.contributor.author Ilčíková, Markéta
dc.contributor.author Mosnáček, Jaroslav
dc.contributor.author Kronek, Juraj
dc.contributor.author Sedlačík, Michal
dc.relation.ispartof NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application
dc.identifier.isbn 9788087294819
dc.date.issued 2018
utb.relation.volume 2017-October
dc.citation.spage 489
dc.citation.epage 494
dc.event.title 9th International Conference on Nanomaterials - Research and Application, NANOCON 2017
dc.event.location Brno
utb.event.state-en Czech Republic
utb.event.state-cs Česká republika
dc.event.sdate 2017-10-18
dc.event.edate 2017-10-20
dc.type conferenceObject
dc.language.iso en
dc.publisher TANGER Ltd.
dc.subject Carbonyl iron en
dc.subject surface modification en
dc.subject atom transfer radical polymerization en
dc.subject drug delivery en
dc.subject embolization en
dc.subject poly(2-isopropenyl-2-oxazoline) en
dc.description.abstract Magnetic particles play an important role in modern biomedical applications including targeted drug delivery, local embolization of blood veins, hyperthermia etc. Therefore, the development of more effective systems with high biocompatibility is of interest for many researchers. Nevertheless, these magnetic systems have to meet certain criteria necessary for in vivo applications. We have considered key requirements desired from such materials, and we have prepared a promising system based on core-shell particles via surface-initiated atom transfer radical polymerization (ATRP). The finest grade of the carbonyl iron particles was used as a suitable core and the treatment of its surface in acidic environment ensured the presence of hydroxyl groups, which were further coupled with ethoxy groups of (3-Aminopropyl)triethoxysilane. After the functionalization, the immobilization of 2-Bromoisobutyryl bromide, which served as an initiator, was performed. Finally, the initiator-treated particles were grafted with poly(2-isopropenyl-2-oxazoline) (PIPOx) under ATRP conditions as the PIPOx has recently shown a great potential in biomedical applications. The cleaning and washing procedures ensured high purity of the product. The reaction conversion, molar mass and dispersity of PIPOx grafts were investigated using nuclear magnetic resonance and gel permeation chromatography, respectively. The presence of grafted PIPOx was confirmed using Fourier-transform infrared, and energy-dispersive X-ray spectroscopies. The grafted PIPOx layer had negligible effect on particle magnetization as revealed via vibration-sample magnetometry. Synthesized core-shell structures may find utilization as a promising material for local embolization or may serve as a drug delivery system due to the presence of PIPOx bearing the active sites allowing the drug bonding. © 2018 TANGER Ltd. All Rights Reserved. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008202
utb.identifier.obdid 43876776
utb.identifier.scopus 2-s2.0-85052296207
utb.identifier.wok 000452823300080
utb.source d-scopus
dc.date.accessioned 2018-10-03T11:13:02Z
dc.date.available 2018-10-03T11:13:02Z
dc.description.sponsorship Grant Agency of the Czech Republic [17-24730S]; Internal Grant Agency of Tomas Bata University in Zlin [IGA/CPS/2017/004]; Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]; [APVV-15-0545]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Cvek, Martin
utb.contributor.internalauthor Mrlík, Miroslav
utb.contributor.internalauthor Sedlačík, Michal
utb.wos.affiliation [Cvek, Martin; Mrlik, Miroslav; Sedlacik, Michal] Tomas Bata Univ, Univ Inst, Ctr Polymer Syst, Zlin, Czech Republic; [Cvek, Martin] Tomas Bata Univ, Fac Technol, Polymer Ctr, Zlin, Czech Republic; [Ilcikova, Marketa; Mosnacek, Jaroslav; Kronek, Juraj] Slovak Acad Sci, Inst Polymer, Bratislava, Slovakia
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Czech Republic; Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, Czech Republic; Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia
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Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International