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Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents

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dc.title Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Trusova, Marina Evgenievna
dc.contributor.author Postnikov, Pavel S.
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof Journal of Drug Delivery Science and Technology
dc.identifier.issn 1773-2247 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2018
utb.relation.volume 47
dc.citation.spage 67
dc.citation.epage 76
dc.type article
dc.language.iso en
dc.publisher Editions de Sante
dc.identifier.doi 10.1016/j.jddst.2018.06.020
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1773224718302910
dc.subject alginic acid sodium salt en
dc.subject chitosan en
dc.subject Doxorubicin en
dc.subject doxorubicin hydrochloride en
dc.subject Folic acid en
dc.subject folic acid en
dc.subject Polysaccharides en
dc.subject Polytherapy en
dc.subject Targeting en
dc.subject Temozolomide en
dc.subject temozolomide en
dc.description.abstract A major challenge faced by researchers involved in the sphere of drug delivery is the development of innovative multidrug delivery systems. Herein, experimentation focused on preparing nanocomplexes based on chitosan and alginic acid with the purpose of allocating a combination of chemotherapeutic drugs, improving their efficacy and reducing dosage. In order to enhance targeting, conjugation with folic acid was performed. The prepared carriers exhibited a spherical shape with a diameter in the range 70–120 nm, a ζ-potential between 30 and 35 mV with good stability in human serum, and low hemolytic activity of up to 100 μg/mL. Over 800 μg of drugs per mg of carrier were loaded and released, displaying a pH-dependent trend with no physical, chemical and biological interferences, which benefited from the advantage of having full control over the given release of drug. In vitro studies performed on human epithelial cervix carcinoma cells and mouse fibroblast cells clearly demonstrated that said dual-loaded complexes showed greater cytotoxicity than single-loaded and free-drug formulations. The viability of the cells decreased, thereby confirming the primary role played by the targeting molecule. © 2018 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008095
utb.identifier.obdid 43879678
utb.identifier.scopus 2-s2.0-85049463356
utb.identifier.wok 000445162500009
utb.identifier.coden JDDSA
utb.source j-scopus
dc.date.accessioned 2018-08-03T12:49:40Z
dc.date.available 2018-08-03T12:49:40Z
dc.description.sponsorship VIU-RSCABS-89/2018, TPU, Tomsk Polytechnic University; NPU LO1504; 4.5924.2017, Minobrnauka, Ministry of Education and Science of the Russian Federation
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic [NPU LO1504]; Tomsk Polytechnic University [VIU-RSCABS-89/2018]; Russian Ministry of Education and Science [4.5924.2017]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Antonio Di Martino a,b,∗ , Marina E. Trusova b , Pavel S. Postnikov b , Vladimir Sedlarik a a Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic b Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Av. 30, 634050, Tomsk, Russian Federation ∗ Corresponding author. Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic. E-mail address: dimartino@utb.cz (A. Di Martino).
utb.fulltext.dates Received 16 March 2018; Received in revised form 23 June 2018; Accepted 24 June 2018; Available online 25 June 2018
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utb.fulltext.sponsorship This work was funded by the Ministry of Education, Youth and Sports of the Czech Republic (grant no. NPU LO1504), Tomsk Polytechnic University (project VIU-RSCABS-89/2018) and Russian Ministry of Education and Science (Scientific Program no. 4.5924.2017).
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, Zlin, Czech Republic; Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Av. 30, Tomsk, Russian Federation
utb.fulltext.projects LO1504
utb.fulltext.projects VIU-RSCABS-89/2018
utb.fulltext.projects 4.5924.2017
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