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Enhancement of 5-aminolevulinic acid phototoxicity by encapsulation in polysaccharides based nanocomplexes for photodynamic therapy application

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dc.title Enhancement of 5-aminolevulinic acid phototoxicity by encapsulation in polysaccharides based nanocomplexes for photodynamic therapy application en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Pavelková, Alena
dc.contributor.author Postnikov, Pavel S.
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof Journal of Photochemistry and Photobiology B: Biology
dc.identifier.issn 1011-1344 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 175
dc.citation.spage 226
dc.citation.epage 234
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.jphotobiol.2017.08.010
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1011134417305328
dc.subject 5-aminolevulinic acid en
dc.subject controlled delivery chitosan en
dc.subject nanoparticles en
dc.subject photodynamic therapy en
dc.subject polysaccharides en
dc.description.abstract Polysaccharides based nanocomplexes have been developed for encapsulation, controlled delivery and to enhance the phototoxicity of the photosensitizer 5-aminolevulinic acid for application in photodynamic therapy. The nanocomplexes were prepared by coacervation in a solvent free environment using chitosan as polycation while alginic and polygalacturonic acid as polyanions. The complexes showed average dimension in the range 90–120 nm, good stability in simulated physiological media and high drug encapsulation efficiency, up to 800 μg per mg of carrier. Release studies demonstrate the possibility to tune the overall release rate and the intensity of the initial burst by changing the external pH. Cytotoxicity and photocytotoxicity tests confirmed the not toxicity of the used polysaccharides. Cell viability results confirmed the improvement of 5-aminolevulinic acid phototoxicity when loaded into the carrier compared to the free form. No effect of the irradiation on the nanocomplexes structure and on the release kinetics of the drug was observed. The results demonstrate that the prepared formulations have suitable properties for future application in photodynamic therapy and to ameliorate the therapeutic efficacy and overcome the side-effects related to the use of the photosensitizer 5-aminolevulinic acid. © 2017 en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1007497
utb.identifier.obdid 43877162
utb.identifier.scopus 2-s2.0-85029289691
utb.identifier.wok 000413177200028
utb.identifier.pubmed 28915492
utb.identifier.coden JPPBE
utb.source j-scopus
dc.date.accessioned 2017-10-16T14:43:39Z
dc.date.available 2017-10-16T14:43:39Z
dc.description.sponsorship 15-08287Y, GACR, Grantová Agentura České Republiky; CZ.1.05/2.1.00/19.0409, MŠMT, Ministerstvo Školství, Mládeže a Tělovýchovy; LO1504, MŠMT, Ministerstvo Školství, Mládeže a Tělovýchovy
dc.description.sponsorship Czech Science Foundation [15-08287Y]; Ministry of Education, Youth and Sports of the Czech Republic [L01504, CZ.1.05/2.1.00/19.0409]; Tomsk Polytechnic University [VIU-316/2017]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Pavelková, Alena
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Antonio Di Martino a,b,⁎ , Alena Pavelkova a , Pavel S. Postnikov b , Vladimir Sedlarik a a Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic b Tomsk Polytechnic University, Lenin Av. 30, 634050 Tomsk, Russian Federation * Corresponding author at: Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic. E-mail address: dimartino@utb.cz (A. Di Martino).
utb.fulltext.dates Received 20 April 2017 Accepted 6 August 2017 Available online 08 August 2017
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utb.fulltext.sponsorship This work was funded by the Czech Science Foundation (grant no. 15-08287Y), Ministry of Education, Youth and Sports of the Czech Republic (grant no. LO1504 and CZ.1.05/2.1.00/19.0409) and Tomsk Polytechnic University (project VIU-316/2017).
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, Zlin, Czech Republic; Tomsk Polytechnic University, Lenin Av. 30, Tomsk, Russian Federation
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