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Organic-inorganic hybrid nanoparticles controlled delivery system for anticancer drugs

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dc.title Organic-inorganic hybrid nanoparticles controlled delivery system for anticancer drugs en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Guselnikova, Olga Andreevna
dc.contributor.author Trusova, Marina E.
dc.contributor.author Postnikov, Pavel S.
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof International Journal of Pharmaceutics
dc.identifier.issn 0378-5173 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 526
utb.relation.issue 1-2
dc.citation.spage 380
dc.citation.epage 390
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.ijpharm.2017.04.061
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0378517317303708
dc.subject Chitosan en
dc.subject Controlled release en
dc.subject Doxorubicin en
dc.subject Iron nanoparticles en
dc.subject Polylactic acid en
dc.description.abstract The use of organic-inorganic hybrid nanocarriers for controlled release of anticancer drugs has been gained a great interest, in particular, to improve the selectivity and efficacy of the drugs. In this study, iron oxide nanoparticles were prepared then surface modified via diazonium chemistry and coated with chitosan, and its derivative chitosan-grafted polylactic acid. The purpose was to increase the stability of the nanoparticles in physiological solution, heighten drug-loading capacity, prolong the release, reduce the initial burst effect and improve in vitro cytotoxicity of the model drug doxorubicin. The materials were characterized by DLS, ζ-potential, SEM, TGA, magnetization curves and release kinetics studies. Results confirmed the spherical shape, the presence of the coat and the advantages of using chitosan, particularly its amphiphilic derivative, as a coating agent, thereby surpassing the qualities of simple iron oxide nanoparticles. The coated nanoparticles exhibited great stability and high encapsulation efficiency for doxorubicin, at over 500 μg per mg of carrier. Moreover, the intensity of the initial burst was clearly diminished after coating, hence represents an advantage of using the hybrid system over simple iron oxide nanoparticles. Cytotoxicity studies demonstrate the increase in cytotoxicity of doxorubicin when loaded in nanoparticles, indirectly proving the role played by the carrier and its surface properties in cell uptake. © 2017 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1007350
utb.identifier.obdid 43876693
utb.identifier.scopus 2-s2.0-85019202796
utb.identifier.wok 000404491400036
utb.identifier.coden IJPHD
utb.source j-scopus
dc.date.accessioned 2017-09-08T12:14:44Z
dc.date.available 2017-09-08T12:14:44Z
dc.description.sponsorship Czech Science Foundation [15-08287Y]; Ministry of Education, Youth and Sports of the Czech Republic [LO1504, CZ.1.05/2.1.00/19.0409]; RFBR [16-33-00351]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Sedlařík, Vladimír
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