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Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin

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dc.title Development of theranostic agents based on iron oxide-gadolinium-chitosan for controlled release of doxorubicin en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Guselnikova, A.Olga
dc.contributor.author Kurtukov, Viktor V.
dc.contributor.author Postnikov, Pavel S.
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof 8th International Conference on Nanomaterials - Research & Application (NANOCON 2016)
dc.identifier.isbn 9788087294710
dc.date.issued 2016
dc.citation.spage 525
dc.citation.epage 529
dc.event.title 8th International Conference on Nanomaterials - Research and Application, NANOCON 2016
dc.event.location Brno
utb.event.state-en Czech Republic
utb.event.state-cs Česká republika
dc.event.sdate 2016-10-19
dc.event.edate 2016-10-21
dc.type conferenceObject
dc.language.iso en
dc.publisher TANGER Ltd.
dc.relation.uri https://www.confer.cz/nanocon/2016/496-development-of-theranostic-agents-based-on-iron-oxide-gadolinium-chitosan-for-controlled-release-of-doxorubicin
dc.subject iron oxide nanoparticles en
dc.subject gadolinium en
dc.subject chitosan en
dc.subject theranostic en
dc.subject controlled release en
dc.subject doxorubicin en
dc.description.abstract Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, z-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1007310
utb.identifier.obdid 43876292
utb.identifier.scopus 2-s2.0-85017280055
utb.identifier.wok 000410656100092
utb.source d-scopus
dc.date.accessioned 2017-09-08T12:14:33Z
dc.date.available 2017-09-08T12:14:33Z
dc.description.sponsorship 16-33-00351, RFBR, Russian Foundation for Basic Research
dc.description.sponsorship Czech Science Foundation [15-08287Y]; Ministry of Education, Youth and Sports of the Czech Republic [LO1504]; Internal Grant Agency of the Tomas Bata University in Zlin [IGA/CPS/2016/004]; Russian Foundation for Basic Research [16-33-00351]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation DI MARTINO Antonio1, GUSELNIKOVA A. Olga 2,3, KURTUKOV V. Viktor2, POSTNIKOV S. Pavel2, SEDLARIK Vladimir1 1 Tomas Bata University in Zlin, University Institute, Centre of Polymer Systems, Zlin, Czech Republic, EU 2 National Research Tomsk Polytechnic University, Tomsk, Russian Federation 3 University of Chemistry and Technology Prague, Czech Republic, EU
utb.fulltext.dates -
utb.fulltext.references [1] PENG, X. H., QIAN, X., MAO, H., WANG, A. Y., CHEN, Z. G., NIE, S., SHIN, D. M.Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. International Journal of nanomedicine, 2008,3(3), 311-321. [2] ZHANG, F., HUANG, X., QIAN, C., ZHU, L., HIDA, N., NIU, G., CHEN, X. Synergistic enhancement of iron oxide nanoparticle and gadolinium for dual-contrast MRI. Biochemical and biophysical research communications, 2012, 425, (4), 886-891. [3] LI L., WEN J., KUI L., HONGMEI S., FANG L., YAO W., ZHONGWEI G.Superparamagnetic iron oxide nanoparticles as MRI contrast agent for non invasive stem cell labelling and tracking.Theranostic, 2013,3,8. [4] YU, M. K., PARK, J.,JON, S.Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics, 2012, 2,(1), 3. [5] GUSELNIKOVA, O. A., GALANOV, A. I., GUTAKOVSKII, A. K.,POSTNIKOV, P. S. (). The convenient preparation of stable aryl-coated zerovalent iron nanoparticles. Beilstein journal of nanotechnology, 2015, 6, (1), 1192-1198. [6] DI MARTINO, A., SEDLARIK, V. Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy. International journal of pharmaceutics, 2014, 474,1, 134-145. [7] CASTELLÓ, J., GALLARDO, M., BUSQUETS, M. A., ESTELRICH, J. Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2015, 468, 151-158. [8] DI CORATO, R., GAZEAU, F., LE VISAGE, C., FAYOL, D., LEVITZ, P., LUX, F.,WILHELM, C. High-resolution cellular MRI: gadolinium and iron oxide nanoparticles for in-depth dual-cell imaging of engineered tissue constructs. ACS nano, 2013, 7,(9), 7500-7512. [9] MARTINO, A., PAVELKOVA, A., MACIULYTE, S., BUDRIENE, S.,SEDLARIK, V. (. Polysaccharidebased nanocomplexes for co-encapsulation and controlled release of 5-Fluorouracil and Temozolomide. European Journal of Pharmaceutical Sciences, 2016,92,20,276-286.
utb.fulltext.sponsorship This work was funded by the Czech Science Foundation (grant No. 15-08287Y), Ministry of Education, Youth and Sports of the Czech Republic (grant No. LO1504) and Internal Grant Agency of the Tomas Bata University in Zlin (IGA/CPS/2016/004). Olga A. Guselnikova is thankful to Russian Foundation for Basic Research (project no. 16-33-00351).
utb.wos.affiliation [Di Martino, Antonio; Sedlarik, Vladimir] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin, Czech Republic; [Guselnikova, A. Olga; Kurtukov, V. Viktor; Postnikov, S. Pavel] Natl Res Tomsk Polytech Univ, Tomsk, Russia; [Guselnikova, A. Olga] Univ Chem & Technol Prague, Prague, Czech Republic
utb.fulltext.projects 15-08287Y
utb.fulltext.projects LO1504
utb.fulltext.projects IGA/CPS/2016/004
utb.fulltext.projects 16-33-00351
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