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Cytotoxicity of poly(p-phenylenediamine)

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dc.title Cytotoxicity of poly(p-phenylenediamine) en
dc.contributor.author Kuceková, Zdenka
dc.contributor.author Rejmontová, Petra
dc.contributor.author Humpolíček, Petr
dc.contributor.author Kašpárková, Věra
dc.contributor.author Bober, Patrycja
dc.contributor.author Sáha, Petr
dc.contributor.author Stejskal, Jaroslav
dc.relation.ispartof Chemical Papers
dc.identifier.issn 0366-6352 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 71
utb.relation.issue 2
dc.citation.spage 367
dc.citation.epage 372
dc.type article
dc.language.iso en
dc.publisher De Gruyter
dc.identifier.doi 10.1007/s11696-016-0069-4
dc.relation.uri https://link.springer.com/article/10.1007/s11696-016-0069-4
dc.subject Conducting polymers en
dc.subject Cytotoxicity en
dc.subject Mouse embryonic fibroblasts en
dc.subject Poly(p-phenylenediamine) en
dc.description.abstract Although poly(p-phenylenediamine) is an electric non-conductor, it exhibits, analogously to conducting polymers, redox activity and could, therefore, find applications in biomedicine. In the current work, the cytotoxicity of poly(p-phenylenediamine) polymer powder produced by the chemical oxidation of p-phenylenediamine with ammonium peroxydisulfate in acidic aqueous media has been studied. Primary mouse embryonic fibroblasts were used for this purpose. Interestingly, the standard methods for the determination of polymer cytotoxicity based on international standard EN ISO 10993-5 could not be applied. The reason was the interaction of polymer extracts with MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. On the basis of the evaluation of flow cytometry and micrographs taken by fluorescence microscopy on cells treated with extracts of poly(p-phenylenediamine), it can be concluded that the powder polymer possesses severe cytotoxicity. The results suggest that practical application of the polymer within biomedicine is, at the current state of knowledge, difficult, and modification of the preparation techniques and/or subsequent purification of poly(p-phenylenediamine) is needed. © Institute of Chemistry, Slovak Academy of Sciences 2016. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1006905
utb.identifier.obdid 43875950
utb.identifier.scopus 2-s2.0-85003952274
utb.identifier.wok 000394523000013
utb.identifier.coden CHPAE
utb.source j-scopus
dc.date.accessioned 2017-06-27T08:13:12Z
dc.date.available 2017-06-27T08:13:12Z
dc.description.sponsorship 13-00270S, GACR, Grantová Agentura České Republiky
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic [LO1504]; Internal Grant Agency [IGA/CPS/2015/002, IGA/CPS/2016/001]; Czech Science Foundation [13-00270S]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Kuceková, Zdenka
utb.contributor.internalauthor Rejmontová, Petra
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.affiliation Zdenka Kuceková 1, Petra Rejmontová 1,2, Petr Humpolíček 1,2, Věra Kašpárková 1, Patrycja Bober 3, Petr Sáha 1,2, Jaroslav Stejskal 3 1 Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic 2 Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, T.G.M. Sq. 5555, 760 01 Zlin, Czech Republic 3 Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic Petr Humpolíček humpolicek@ft.utb.cz
utb.fulltext.dates Received: 24 March 2016 Accepted: 28 June 2016 Published online: 9 December 2016
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Polymer Centre
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Polymer Centre
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Polymer Centre
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