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Enhancement of temozolomide stability by loading in chitosan-carboxylated polylactide-based nanoparticles

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dc.title Enhancement of temozolomide stability by loading in chitosan-carboxylated polylactide-based nanoparticles en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Kucharczyk, Pavel
dc.contributor.author Capáková, Zdenka
dc.contributor.author Humpolíček, Petr
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof Journal of Nanoparticle Research
dc.identifier.issn 1388-0764 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 19
utb.relation.issue 2
dc.type article
dc.language.iso en
dc.publisher Springer Netherlands
dc.identifier.doi 10.1007/s11051-017-3756-3
dc.relation.uri https://link.springer.com/article/10.1007/s11051-017-3756-3
dc.subject Chitosan en
dc.subject Drug delivery en
dc.subject Encapsulation en
dc.subject Nanomedicine en
dc.subject Nanoparticles en
dc.subject Polylactic acid en
dc.subject Temozolomide en
dc.description.abstract In the presented work, amphiphilic nanoparticles based on chitosan and carboxy-enriched polylactic acid have been prepared to improve the stability of the pro-drug temozolomide in physiological media by encapsulation. The carrier, with a diameter in the range of 150–180 nm, was able to accommodate up to 800 μg of temozolomide per mg of polymer. The obtained formulation showed good stability in physiological condition and preparation media up to 1 month. Temozolomide loaded inside the carrier exhibited greater stability than the free drug, in particular in simulated physiological solution at pH 7.4 where the hydrolysis in the inactive metabolite was clearly delayed. CS-SPLA nanoparticles demonstrated a pH-dependent TMZ release kinetics with the opportunity to increase or decrease the rate. Mass spectroscopy, UV-Vis analysis, and in vitro cell tests confirmed the improvement in temozolomide stability and effectiveness when loaded into the polymeric carrier, in comparison with the free drug. © 2017, The Author(s). en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006903
utb.identifier.obdid 43877200
utb.identifier.scopus 2-s2.0-85013324745
utb.identifier.wok 000394542400001
utb.identifier.pubmed 28260965
utb.source j-scopus
dc.date.accessioned 2017-06-27T08:13:11Z
dc.date.available 2017-06-27T08:13:11Z
dc.description.sponsorship 15-08287Y, GACR, Grantová Agentura České Republiky; 15-08287Y, GAČR, Grantová Agentura České Republiky; CZ.1.05/2.1.00/19.0409, MŠMT, Ministerstvo Školství, Mládeže a Tělovýchovy; LO1504, MŠMT, Ministerstvo Školství, Mládeže a Tělovýchovy
dc.description.sponsorship Czech Science Foundation [15-08287Y]; Ministry of Education, Youth and Sports of the Czech Republic [LO1504, CZ.1.05/2.1.00/19.0409]; Internal Grant Agency of the Tomas Bata University in Zlin [IGA/CPS/2016/004]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Kucharczyk, Pavel
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation A. Di Martino : P. Kucharczyk : Z. Capakova : P. Humpolicek : V. Sedlarik (*) Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, tr. T. Bati 5678, 76001 Zlin, Czech Republic e-mail: sedlarik@ft.utb.cz
utb.fulltext.dates Received: 24 August 2016 / Accepted: 24 January 2017 / Published online: 16 February 2017
utb.fulltext.sponsorship This work was funded by the Czech Science Foundation (grant no. 15-08287Y), Ministry of Education, Youth and Sports of the Czech Republic (grants nos. LO1504 and CZ.1.05/2.1.00/19.0409), and Internal Grant Agency of the Tomas Bata University in Zlin (grant no. IGA/CPS/2016/004)
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Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International