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Synthesis and examination of nanocomposites based on poly(2-hydroxyethyl methacrylate) for medicinal use

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dc.title Synthesis and examination of nanocomposites based on poly(2-hydroxyethyl methacrylate) for medicinal use en
dc.contributor.author Kukolevska, Olena S.
dc.contributor.author Gerashchenko, Igor I.
dc.contributor.author Borysenko, Mykola V.
dc.contributor.author Pakhlov, Evgenii M.
dc.contributor.author Machovský, Michal
dc.contributor.author Yushchenko, Tetyana I.
dc.relation.ispartof Nanoscale Research Letters
dc.identifier.issn 1931-7573 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 12
utb.relation.issue 1
dc.type article
dc.language.iso en
dc.publisher Springer
dc.identifier.doi 10.1186/s11671-017-1881-7
dc.relation.uri https://nanoscalereslett.springeropen.com/articles/10.1186/s11671-017-1881-7
dc.subject Biologically active compounds en
dc.subject Controlled release en
dc.subject Nanocomposites en
dc.subject Poly(2-hydroxyethyl methacrylate) en
dc.subject Pore formation en
dc.subject Silica en
dc.description.abstract Preparation of poly(2-hydroxyethyl methacrylate) (PHEMA) based nanocomposites using different approaches such as synthesis with water as the porogen, filling of polymer matrix by silica and formation of interpenetrating polymer networks with polyurethane was demonstrated. Incorporation of various biologically active compounds (BAC) such as metronidazole, decamethoxin, zinc sulphate, silver nitrate or amino acids glycine and tryptophan into nanocomposites was achieved. BAC were introduced into the polymer matrix either (1) directly, or (2) with a solution of colloidal silica, or (3) through immobilization on silica (sol-densil). Morphology of prepared materials was investigated by laser scanning microscopy and low-vacuum scanning electron microscopy. In vacuum freeze-drying, prior imaging was proposed for improving visualization of the porous structure of composites. The interaction between PHEMA matrix and silica filler was investigated by IR spectroscopy. Adsorption of 2-hydroxyethyl methacrylate and BAC from aqueous solution on the silica surface was also examined. Phase composition and thermal stability of composites were studied by the differential thermogravimetry/differential thermal analysis. Release of BAC into water medium from prepared composites were shown to depend on the synthetic method and differed significantly. Obtained PHEMA-base materials which are characterized by controlled release of BAC have a strong potential for application in manufacturing of different surgical devices like implants, catheters and drainages. © 2017, The Author(s). en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006894
utb.identifier.obdid 43877203
utb.identifier.scopus 2-s2.0-85013249534
utb.identifier.wok 000397583800003
utb.identifier.pubmed 28235364
utb.source j-scopus
dc.date.accessioned 2017-06-27T08:13:08Z
dc.date.available 2017-06-27T08:13:08Z
dc.rights Attribution 4.0 International
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Machovský, Michal
utb.fulltext.affiliation Olena S. Kukolevska 1,3* , Igor I. Gerashchenko 1 , Mykola V. Borysenko 1 , Evgenii M. Pakhlov 1 , Michal Machovsky 2 and Tetyana I. Yushchenko 3 * Correspondence: clemans2009@rambler.ru 1 Chuiko Institute of Surface Chemistry, NAS of Ukraine, 17 General Naumov Str., Kyiv 03164, Ukraine. 2 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, Zlin 76001, Czech Republic. 3 Vinnytsia National Pyrogov Memorial Medical University, 56 Pyrogov Str., Vinnytsia 21018, Ukraine.
utb.fulltext.dates Received: 28 November 2016 Accepted: 31 January 2017; Published online 20 February 2017
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Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International