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Adhesion, proliferation and migration of NIH/3T3 cells on modified polyaniline surfaces

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dc.title Adhesion, proliferation and migration of NIH/3T3 cells on modified polyaniline surfaces en
dc.contributor.author Rejmontová, Petra
dc.contributor.author Capáková, Zdenka
dc.contributor.author Mikušová, Nikola
dc.contributor.author Maráková, Nela
dc.contributor.author Kašpárková, Věra
dc.contributor.author Lehocký, Marián
dc.contributor.author Humpolíček, Petr
dc.relation.ispartof International Journal of Molecular Sciences
dc.identifier.issn 1422-0067 Scopus Sources, Sherpa/RoMEO, JCR
dc.identifier.issn 1661-6596 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 17
utb.relation.issue 9
dc.type article
dc.language.iso en
dc.publisher MDPI AG
dc.identifier.doi 10.3390/ijms17091439
dc.relation.uri http://www.mdpi.com/1422-0067/17/9/1439
dc.subject Cyto-compatibility en
dc.subject Fibroblast en
dc.subject Phosphotungstic acid en
dc.subject Poly (2-acrylamido-2-methyl-1-propanesulfonic) acid en
dc.subject Polyaniline en
dc.subject Sulfamic acid en
dc.description.abstract Polyaniline shows great potential and promises wide application in the biomedical field thanks to its intrinsic conductivity and material properties, which closely resemble natural tissues. Surface properties are crucial, as these predetermine any interaction with biological fluids, proteins and cells. An advantage of polyaniline is the simple modification of its surface, e.g., by using various dopant acids. An investigation was made into the adhesion, proliferation and migration of mouse embryonic fibroblasts on pristine polyaniline films and films doped with sulfamic and phosphotungstic acids. In addition, polyaniline films supplemented with poly (2-acrylamido-2-methyl-1-propanesulfonic) acid at various ratios were tested. Results showed that the NIH/3T3 cell line was able to adhere, proliferate and migrate on the pristine polyaniline films as well as those films doped with sulfamic and phosphotungstic acids; thus, utilization of said forms in biomedicine appears promising. Nevertheless, incorporating poly (2-acrylamido-2-methyl-1-propanesulfonic) acid altered the surface properties of the polyaniline films and significantly affected cell behavior. In order to reveal the crucial factor influencing the surface/cell interaction, cell behavior is discussed in the context of the surface energy of individual samples. It was clearly demonstrated that the lesser the difference between the surface energy of the sample and cell, the more cyto-compatible the surface is. © 2016 by the authors; licensee MDPI, Basel, Switzerland. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006743
utb.identifier.obdid 43875260
utb.identifier.scopus 2-s2.0-84988493722
utb.identifier.wok 000385525500066
utb.source j-scopus
dc.date.accessioned 2016-12-22T16:19:03Z
dc.date.available 2016-12-22T16:19:03Z
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic, Program NPU I [LO1504]
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Rejmontová, Petra
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Mikušová, Nikola
utb.contributor.internalauthor Maráková, Nela
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Humpolíček, Petr
utb.fulltext.affiliation Petra Rejmontová, Zdenka Capáková, Nikola Mikušová, Nela Maráková, Věra Kašpárková, Marián Lehocký and Petr Humpolíček * Centre of Polymer Systems, Tomas Bata University in Zlín, třída Tomáše Bati 5678, 760 01 Zlín, Czech Republic; rejmontova@cps.utb.cz (P.R.); kucekova@cps.utb.cz (Z.C.); mikusova@ft.utb.cz (N.M.); marakova@ft.utb.cz (N.M.); vkasparkova@ft.utb.cz (V.K.); lehocky@ft.utb.cz (M.L.) * Correspondence: humpolicek@ft.utb.cz; Tel.: +420-576-038-035
utb.fulltext.dates Received: 28 July 2016; Accepted: 26 August 2016; Published: 15 September 2016
utb.fulltext.sponsorship This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic, Program NPU I (LO1504).
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